@article{article_809771, title={Comparison of Cervical Pathologies in Presence of High-Risk HPV Positivity in Women with Normal Cytology}, journal={Türk Jinekolojik Onkoloji Dergisi}, volume={22}, pages={19–26}, year={2021}, author={Kılınçlı, Eda and Kadiroğulları, Pınar and Deniz, Necip and Akgol, Sedat and Ülker, Volkan and Akbayir, Ozgur}, keywords={Yüksek Riskli HPV, Servical İntraepitelyal Neoplazi, Servical Neoplasm, Kolposkopi, Human Papillomavirus}, abstract={Aim: Regarding the cervical cancer screening program, who are HPV-16/18 positive, undergo colposcopy. Patients, who have a negative smear but high-risk HPV positivity except for type 16-18, are examined with cotesting one year later. In this study, our objective was to compare the results of patients, who had type 16/18 HPV positivity and non-16/18 HPV positivity. Methods: The results of 409 patients, who had high-risk HPV (HR-HPV) positivity and negative cytology, were evaluated retrospectively. Demographic data, body mass index (BMI) and histological classification were recorded. The histopathological findings obtained with the colposcopic examination in patients (n=192), who had normal cytology and non-16/18 HR-HPV positivity, were compared with the histopathological findings obtained with a colposcopic examination in patients (n=217), who had type 16-18 HR-HPV positivity. Results: The mean age and BMI were 41.6±8.5 years and 29.2±4.4. A total of 409 women were assessed and 217 of them had type 16-18 HR-HPV positivity (53%) and 192 had non-16/18 HR-HPV positivity (47%). The following colposcopic biopsy results were obtained in women with type 16-18 HR-HPV positivity: 147 patients had normal biopsy results (67.7%); 68(31.4%) patients had premalignant cervical lesions and 2 patients had invasive cervix carcinoma (0.9%). Regarding the women with non-16/18 HR-HPV positivity, the colposcopic biopsy results were as follows: 159 patients had normal biopsy results (83%); 32(16.6%) patients had premalignant cervical lesions and 1 patient had invasive cervix carcinoma (0.5%). The rate of abnormal biopsy results was significantly higher in Group1 (p=0.003). Conclusions: Infections caused by HPV16/18, ≥CIN2 lesions are related to high risk. We determined invasive cervix carcinoma in 2 of patients with type 16-18 HR-HPV positivity and in 1 of patients with non-16/18 HR-HPV positivity. Due to the small number of patients in our study, we believe that there is a need for more comprehensive studies and for the investigation of the benefits of the colposcopy in all types of HR-HPV infections.}, number={1}, publisher={Türk Jinekolojik Onkoloji Derneği}