@article{article_821483, title={Frequency of Sickle Cell Trait in the patients with chronic kidney diseases in a tertiary center in Turkey}, journal={Balıkesir Medical Journal}, volume={4}, pages={55–59}, year={2020}, author={Sürmeli Döven, Serra and Ünal, Selma and Demir, Serap and Bardak, Simge and Karahan, Feryal and Güneş, Ayşe and Delibaş, Ali}, keywords={Kronik böbrek hastalığı, Orak hücreli anemi taşıyıcılığı, Orak hücreli anemi hastalığı}, abstract={Aim: Sickle Cell Disease and Sickle Cell Trait (SCT) is commonly seen in Çukurova region in Turkey. Renal manifestations of the sickle cell trait (SCT) include renal concentration defects, renal papillary necrosis, and hematuria. Conflicting results were reported regarding whether the SCT leads to chronic renal failure. Frequency of Sickle Cell Trait in the patients with chronic kidney diseases has yet to be reported in Turkey. This study evaluated the SCT frequency in patients with chronic kidney diseases in a single center in Turkey. Materials and Methods: A total of 164 patients with chronic kidney disease such as chronic renal failure, tubulopathy, proteinuria, and hematuria who were followed-up in the Pediatric and Adult Nephrology Departments in a center were enrolled in the study. Information regarding diagnosis, hemoglobin levels, glomerular filtration rate, urine density, proteinuria, hematuria, and family history for sickle cell disorder were collected from the records retrospectively. HbS and HbA values were evaluated using hemoglobin electrophoresis. Results: The mean age of the patients was 33.18±27.33 years (min.-maks. 1-92 years). Ninety-two (56.1%) had chronic renal failure, 19 (11.6%) had tubulopathy, 22 (13.4%) had proteinuria, and 31 (18.9%) had hematuria. SCT was detected in three adult patients (1.8%) with chronic renal failure. Conclusion: The SCT was not associated with increased frequency of chronic kidney diseases according to this study. Further studies with a larger sample size are needed to support this result.}, number={3}, publisher={Balıkesir Üniversitesi}