TY  - JOUR
T1  - STUDY OF THE STRUCTURE OF PRODUCTS OF INTERACTION BETWEEN SOME NAPHTHOQUINONE DERIVATIVES AND PHARMACEUTICAL SUBSTANCES
TT  - BAZI NAFTOKİNON TÜREVLERİ İLE İLAÇ MADDELERİ ARASINDAKİ ETKİLEŞİM ÜRÜNLERİNİN YAPISININ İNCELENMESİ
AU  - Donchenko, Anastasiia
AU  - Miedviedieva, Kateryna
AU  - Voskoboınık, Oleksii
AU  - Vasyuk, Svitlana
AU  - Kovalenko, Serhii
PY  - 2021
DA  - May
Y2  - 2021
DO  - 10.33483/jfpau.835875
JF  - Journal of Faculty of Pharmacy of Ankara University
JO  - J. Fac. Pharm. Ankara
PB  - Ankara Üniversitesi
WT  - DergiPark
SN  - 1015-3918
SP  - 321
EP  - 331
VL  - 45
IS  - 2
LA  - en
AB  - Objective: The purpose of the present work is to detail а study of the interaction between naphthoquinone-based analytical reagents and such pharmacologically active ingredients as acetylcysteine, β-alanine and taurine (2-aminoethanesulfonic acid) including the isolation and structure elucidation of the formed products.Material and Method: UV-visible spectrophotometry was applied to determine the stoichiometric coefficients of reactants in reactions between the pharmaceutical substances and naphthoquinone derivatives. 1Н NMR-spectroscopy, IR spectroscopy, сhromatomass-spectrometry were used to prove the structure of the reaction products.Result and Discussion: The stoichiometric relationships of the reactants in the investigated medicinal substances reactions with quinone derivatives were determined by the methods of saturation and continuous changes. They are 1:1 in each case. According to the determined relationships of components reaction and optimal conditions for reactions path, the products of interaction of acetylcysteine with 2,3-dichloro-1,4-naphthoquinone and taurine, β-alanine with sodium 1,2-naphthoquinone-4-sulfonate were isolated and identified. In order to establish the structure of the compounds, the 1Н NMR-spectroscopy, IR spectroscopy, сhromatomass-spectrometry were used.
KW  - Acetylcysteine
KW  - β-alanine
KW  - taurine
KW  - naphthoquinone derivatives
KW  - reaction products
N2  - Amaç: Naftokinon esaslı analitik reaktiflerin asetilsistein, β-alanin ve taurin (2-aminoetanosülfonik asit) gibi farmasötik açıdan aktif maddelerle etkilişimin, oluşan ürünlerin ayırımı yapı oluşumu dahil olmak üzere detaylı incelemesidir.Gereç ve Yöntem: Farmasötik maddeler ile naftokinon türevleri arasındaki reaksiyonlarda reaktanların stokiyometrik katsayılarını belirlemek için UV - Vis spektrofotometri yöntemi uygulandı. Reaksiyon ürünlerinin yapısını kanıtlamak için 1Н NMR-spektroskopi, IR spektroskopi, kütle spektrometrisi kullanıldı.Sonuç ve Tartışma: Kinon türevleri ile araştırılan tıbbi maddelerin reaksiyonlarında reaktanların stokiyometrik ilişkileri, doyurma ve sürekli değişim yöntemleri ile belirlenmiştir. İlişki her durumda 1: 1'dir. Bileşen reaksiyonu ve reaksiyon yolu için optimal koşulların belirlenen ilişkilerine göre, asetilsisteinin 2,3-dikloro-1,4-naftokinon ve taurin ile, β-alanin ile sodyum 1,2-naftokinon-4-sülfonat ile etkileşim ürünleri izole edilmiş ve tanımlanmıştır. Bileşiklerin yapısını oluşturmak için 1Н NMR-spektroskopi, IR spektroskopisi, kütle spektrometrisi kullanılmıştır.
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UR  - https://doi.org/10.33483/jfpau.835875
L1  - https://dergipark.org.tr/tr/download/article-file/1430999
ER  -