TY - JOUR T1 - L-Carnitine treatment in a child with valproic acid intoxication AU - Arslanoğlu, Mehmet Özgür AU - Kaçmaz, Ebru AU - Bozan, Gürkan AU - Dınleyıcı, Ener Cagri AU - Özkan, Burak AU - Sahin, Sabiha PY - 2021 DA - April Y2 - 2021 JF - Eurasian Journal of Critical Care JO - Eurasian j Crit Care PB - Acil Tıp Uzmanları Derneği WT - DergiPark SN - 2667-8721 SP - 36 EP - 38 VL - 3 IS - 1 LA - en AB - With its growing application in neurological and psychiatric diseases, valproic acid overdose due to acute and chronic use has been causing emergency admission. Asymptomatic cases of hyperammonemia may be found in valproic acid poisoning ranging from central nervous system depression to coma. While supportive therapy is adequate, in most cases active charcoal, levocarnitine supplementation, and treatment with naloxane and hemodialysis, when needed, can also be used. In the case study reported in this paper, we aimed to focus at bringing awareness to the use of levocarnitine in asymptomatic patients with valproic acid poisoning accompanied by hyperammonemia. KW - hyperammonemia KW - intoxication KW - L-carinitine KW - valproik acid CR - 1.Sztajnkrycer MD. Valproic acid toxicity: overview and management. J Toxicol Clin Toxicol. 2002; 40(6): 789-801. CR - 2.Andersen GO, Ritland S. Life threatening intoxication with sodium valproate. J Toxicol Clin Toxicol. 1995; 33(3): 279-284. CR - 3.Nau H, Loscher W. Valproic acid and metabolites: pharmacological and toxicological studies. Epilepsia. 1984; 25 Suppl 1:S14-22. CR - 4.Lheureux PE, Penaloza A, Zahir S, Gris M. Science review: carnitine in the treatment of valproic acid-induced toxicity - what is the evidence? Crit Care. 2005; 9(5): 431-40. CR - 5.Lheureux PE, Hantson P. Carnitine in the treatment of valproic acid-induced toxicity. Clin Toxicol (Phila). 2009; 47(2): 101-11. CR - 6.Katiyar A, Aaron C. Case files of the Children's Hospital of Michigan Regional Poison Control Center: the use of carnitine for the management of acute valproic acid toxicity. J Med Toxicol. 2007; 3(3): 129-38. CR - 7.Ingels M, Beauchamp J, Clark RF, Williams SR. Delayed valproic acid toxicity: a retrospective case series. Ann Emerg Med. 2002;39(6): 616-21 CR - 8.Ghannoum M, Laliberté M, Nolin TD, MacTier R, Lavergne V, Hoffman RS, Gosselin S; EXTRIP Workgroup. Extracorporeal treatment for valproic acid poisoning: systematic review and recommendations from the EXTRIP workgroup. Clin Toxicol (Phila). 2015; 53(5): 454-65. CR - 9.Ishikura H, Matsuo N, Matsubara M, Ishihara T, Takeyama N, Tanaka T. Valproic acid overdose and L-carnitine therapy. J Anal Toxicol. 1996; 20(1): 55-8. UR - https://dergipark.org.tr/tr/pub/ejcc/issue//846827 L1 - https://dergipark.org.tr/tr/download/article-file/1468095 ER -