TY  - JOUR
T1  - Leigh Sendromu: Beyin MRG ve MR Spektroskopi Bulguları
TT  - Leigh Syndrome: Cranial MRI and MR Spectroscopy Findings
AU  - Aydın, Hasan
AU  - Kızılgöz, Volkan
AU  - Hekimoğlu, Baki
PY  - 2011
DA  - April
JF  - Fırat Tıp Dergisi
PB  - Fırat Üniversitesi
WT  - DergiPark
SN  - 1300-9818
SP  - 102
EP  - 105
VL  - 16
IS  - 2
LA  - tr
AB  - On yaşında kız çocuğu acil ünitesine; nöbet, ellerinde myotonik-klonik kasılmalar, kusma, solunum kaybı ve hafif metabolik asidoz bulguları ile  başvurdu. Beyin Manyetik Rezonans Görüntüleme (MRG) ve proton-MR Spektroskopi yapıldı. MRG bulguları; Simetrik bazal ganglion, beyin sapı,  sol talamus ve subtalamik çekirdek tutulumu içermekteydi. Bazal ganglion ve talamus lezyonlarından alınan MR Spektroskopi de; artmış laktat ve  kolin pikleri, azalmış NAA\Krea and NAA\Kol oranlarını gösterdi. Beyin omurilik sıvısında da artmış aktat mevcuttu. Görüntüleme bulguları ile  birlikte klinik süreç ve laboratuar verileride Leigh sendromu genç erişkin tip tanısını desteklediğinden, teşhis için kas biyopsisine gerek duyulmadı.
KW  - Leigh sendromu
KW  - beyin MR
KW  - MR Spektroskopi
KW  - bazal ganglion
KW  - talamus
N2  - A 10 years old girl, was admitted to the intensive care unit with seizure, myotonic-clonic jerks in her hands, vomiting, respiratory failure and mild  metabolic acidosis. Brain Magnetic resonance imaging (MRI) and proton MR spectroscopy(MRS) were performed.The MRI findings presented  symmetric basal ganglia, brain stem, left thalamus and subthalamic nuclei involvement. MRS obtained from the basal ganglia and thalamus lesions,  showed increased lactate and choline peak, decreased NAA\Crea and NAA\Cho ratios. In the CSF, there was also increased lactate. These imaging  findings, clinical course and the laboratory data were used for the diagnosis of Juvenile form of Leigh syndrome. Muscle biopsy wasn't needed for  the diagnosis.
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CR  - Gönderilme Tarihi: 16.06.2010
UR  - https://dergipark.org.tr/tr/pub/firattip/issue//84737
L1  - https://dergipark.org.tr/tr/download/article-file/72209
ER  -