TY - JOUR T1 - Ortalama Eritrosit Hacmi Düzeyinin Alkolik Karaciğer Sirozu Tanısındaki Yerinin Belirlenmesi ve Prognoza Etkisinin İrdelenmesi TT - Determination of the Role of Mean Corpuscular Volume Level on the Diagnosis of Alcoholic Liver Cirrhosis and Investigation of Its Effect on the Prognosis AU - Tanrıverdi, Özgür AU - Ger, Esen AU - Uzunoğlu, Sernaz AU - Serez, M. Kemal AU - Üre, B. Ümit AU - Ergen, Kadir AU - Kumbasar, A.baki PY - 2008 DA - February JF - Fırat Tıp Dergisi PB - Fırat Üniversitesi WT - DergiPark SN - 1300-9818 SP - 49 EP - 52 VL - 13 IS - 1 LA - tr AB - Amaç: Alkolik karaciğer sirozunda(AKS) makrositoz sıklığı ve makrositoz ile prognoz arasındaki ilişkinin belirlenerek doğruluk, duyarlılık ve özgüllük değerlerinin tespiti amaçlanmıştır. Gereç ve Yöntem: AKS tanısı olan toplam 46 hasta(grup 1)ile Hepatit B ve C virüslerine bağlı karaciğer sirozu (KS)tanısı olan 51 hastanın(grup 2) ortalama eritrosit hacmi(OEH) düzeyleri retrospektif olarak karşılaştırıldı. Bulgular: Grup 1'de OEH değeri 94.6±10.87 olup, grup 2 hastalardan anlamlı olarak yüksek saptandı(p KW - Siroz KW - alkol KW - makrositoz KW - prognoz N2 - Objectives: In this study, we aimed to determine the relationship between macrocytosis and Alcoholic Liver Cirrhosis (ALC) and its accuracy, sensitivity and specificity rates. Material and Methods: Mean corpuscular volume (MCV) levels of 46 patients diagnosed as having ALC (Group 1) and 51 patients diagnosed as having Hepatitis B cirrhosis and Hepatitis C cirrhosis (Group 2) were compared retrospectively. Results: MCV level determined as 94.6±10.87 in patients in Group 1 was statistically significantly higher than in patients in Group 2 (p CR - Rutherford CJ, Frenkel PF. Hemostatic disorders in liver disease. In:Schiff ER, Sorrell MF, Maddrey WC (Editors). Schiff’s Diseases of the Liver. 8. edition , Philedelphia-New York: Lippincott-Raven Publishers, 1999: 583-598 CR - Pasqualetti P, Festuccia V, MacCarone C, DiLaura G, Casale R. Diagnostic value of gamma glutamyl transpeptidase and the mean corpusculer volume in chronic hepatitis of alcoholic etiology. Minerva Med 1995; 86: 395-402 CR - Soysal T. Megaloblastic Anemias. In: Soysal T, Soycan LY (Editors). Continuous Medical Education Symposium Serial of Cerrahpasa Medical Faculty of Istanbul University. Istanbul: Kaya Publishers, 2001: 33-47 CR - Mates M, Heyd J, Soununjon M et all. The haematologist as watcdog of community health by full blood count. QJM 1995; 88: 333-339 CR - Riedler GF, Zollinger P, Schmid M. Changes in the blood picture in liver diseases. Schweiz Med Wochenshr 1975; 105: 1593 CR - Intragumtornchai T, Rojnukkarin Vajanamarhutue C, Israsena S. Anemias in Thai patients with cirrhosis. Int J Hematol(Ireland) 1997; 65: 365-373 P, Swasdikul D, CR - Maruyama S, Hirayama C, Yamamato et all. Red blood cell status in alcoholic and non-alcoholic liver diseases. J Lab Med 2001: 138: 332-337 CR - Sherlock S, Dooley J. Alcohol and liver. In:Sherlock S, Dooley J (Editors). Diseases of the liver and biliary system. 10. baskı, Oxford: Blackwell Science Ltd, 1997: 385-400 CR - Wu A, Chanarin I, Slavin G, Levi AJ. Folate deficiency in the alcoholics-its relationship to clinical and haematological abnormalities, liver disease and folate stores. Br Haematol 1975; 29: 469-478 CR - Seppa K, Sillanaukee P. Women, alcohol and red cells. Alcohol Clin Exp Res. 1994: 18: 1168-1171 CR - Oski FA. Anemia due to other nutritional deficiencies. In: Beutler E, Lichtman MA, Coller BS, Kipps TJ (Editors). Williams Hematology. 5. baskı, McGraw Hill Health Professions Division International Edition, 1995: 511-514 CR - Balcells A, Ingelmo M, Vivancos J et all. Macrocytosis in chronic alcoholism (author’s transl). Med Clin (barc) 1979; 73 :312-314 CR - Gheno G, Magnabosco V, Mazzei G. Macrocytosis and anemia in chronic alcoholism. Correlation with the results of hepatic needle biopsy. Minerva Med 1981; 72: 1301-1306 CR - Yersin B, Nicolet JF, Dercy et all. Screening for excessive alcohol drinking; comparative value of carbohaydrate deficient transferin, gamma glutamyl transpeptidase and mean corpuscular volume. Arch Intern Med 1995; 155: 1907-1911 CR - Sun L, Konig IR, Jacobs A, et al. Mean corpuscular volume and ADH1C genotype in white patients with alcohol-associated diseases. Alcohol Clin Exp Res 2005;29:788-93 CR - Kabul Tarihi: 02.11.2007 UR - https://dergipark.org.tr/tr/pub/firattip/issue//84955 L1 - https://dergipark.org.tr/tr/download/article-file/72427 ER -