TY  - JOUR
T1  - The benefit of surgery on survival for patients with stage 1 and 2 malignant pleural mesothelioma
TT  - The benefit of surgery on survival for patients with stage 1 and 2 malignant pleural mesothelioma
AU  - Ocak, Birol
AU  - Şahin, Ahmet Bilgehan
PY  - 2020
DA  - December
DO  - 10.5798/dicletip.850203
JF  - Dicle Medical Journal
JO  - diclemedj
PB  - Dicle Üniversitesi
WT  - DergiPark
SN  - 1300-2945
SP  - 770
EP  - 778
VL  - 47
IS  - 4
LA  - en
AB  - Objective: Malignant mesothelioma is a rare and aggressive cancer. We aim to report our experience of stage 1 and 2 malign pleural mesothelioma (MPM) and investigate the prognostic factors.Methods: We retrospectively reviewed 37 patients with clinical stage 1 and 2 MPM in our center and examined radiological findings, demographic characteristics, treatment modalities, survival, and recurrence.Results: Eighteen of the 37 patients were male, and the mean age of the patients was 59.0 ± 11.2 years. Thirty patients had stage 1 MPM, and 7 patients had stage 2. Seven patients underwent surgery, and 30 patients received induction chemotherapy. Median progression-free survival (PFS) was 12.3 months (95% confidence interval [CI], 9.4-15.1), and the median overall survival (OS) was 24.3 months (95% CI, 15.8-32.8). In multivariate analysis, while gender and surgery had a statistically significant effect on PFS (p=0.01, p=0.01, respectively), both gender and surgery did not significantly affect OS (p=0.15, p=0.08, respectively). Local recurrence occurred in 28 patients, and 7 patients were presented with local recurrence and distant metastasis.Conclusion: In our study, where the majority of patients were stage 1 and 2, the effect of the surgery was significant.
KW  - Chemotherapy
KW  - malign pleural mesothelioma
KW  - stage 1-2
CR  - 1.Hiriart E, Deepe R, Wessels A. Mesothelium andMalignant Mesothelioma. J Dev Biol. 2019; 7.
UR  - https://doi.org/10.5798/dicletip.850203
L1  - https://dergipark.org.tr/tr/download/article-file/1478093
ER  -