TY - JOUR T1 - Deksmedetomidin and fentanyl attenuatethe propofol injection pain TT - Deksmedetomidin ve fentanil propofol enjeksiyon ağrısını gideriyor AU - Mızrak, Ayşe AU - Koruk, Senem AU - Gül, Rauf AU - Ganidağlı, Süleyman AU - Bozgeyik, Şemsettin AU - Öner, Ünsal PY - 2009 DA - April JF - Gaziantep Medical Journal PB - Gaziantep Üniversitesi WT - DergiPark SN - 2148-3132 SP - 17 EP - 22 VL - 15 IS - 3 LA - tr AB - Bu çalışmayı, venöz yol ile verilen deksmedetomidin ve fentanilin propofol enjeksiyon ağrısı üzerine olan etkisini karşılaştırmak üzere gerçekleştirdik. Genel anestezi altında elektif cerrahi geçirecek olan, premedikasyon yapılmamış (18-65 yaş), yetişkin hasta ile bir prospektif, randomize ve çift kör çalışma planladık. Hastalar gelişigüzel 3 gruba ayrıldı (n=40)- Fentanil (F), deksmedetomidin (D) ve Kontrol (C). 10 mililitrelik çalışma solüsyonu sabit 10 saniye içinde enjekte edildi. Fentanil (1 ug/ kg) ya da deksmedetomidin (0.15 ug/ kg) ya da plasebo verildikten 60 saniye sonra propofol 2,5 mg/kg 20 ml/ dakika hızla infuze edildi Enjeksiyon ağrısı four-point sözel skalası kullanılarak değerlendirildi Propofol ilişkili enjeksiyon ağrısının oranları grup C için. %65 (26), F grubu için: %27 (16) ve grup D için %25 (10) idi. Ağrı oranı fentanil ve özellikle de deksmedetomidin grubunda kontrol grubuna göre daha azdı (p < 0.05). Gruplardakı şiddetli ağrı, D KW - Deksmedetodimin KW - Fentanil KW - Propofol KW - Enjeksiyonlar KW - Anestezi KW - ven içi KW - Premedikasyon KW - Ağrı KW - Hemodinamikler KW - Analjezikler N2 - We performed this study to compare the effects of intravenous dexmedetomidine and fentanyl on propofof injection pain. We conducted a prospective, randomized and double blind study of 120 adult unpremedicated patients (18-65 years of age) scheduled to undergo elective surgery under general anesthesia. The patients were allocated randomly into three groups (n=40): fentanyl (F), dexmedetomidine (D), and Control (C). Ten ml of the study solution was injected over 10 seconds. One minute after the administration of fentanyl (1 ug/ kg) or dexmedetomidine (0,15 ug/ kg) or placebo, propofol 2,5 mg/ kg was Infused at a rate of 20 ml/ min. Injection pain was assessed using a four - point verbal rating scale. The incidence of propofol-associated injection pain were 65% (26) for group C, 27% (16) for group F, and 25% (10) for group D. The incidence of pain were less in the"fentanyl, and especially in the dexmedetomidine groups than control group (p < 0.05). Severe pain in groups were D CR - 1.Angst MS, Mackey SC, Zupfer GH. Reduction of propofol injection pain with a double lumen i.v. set. J Clin Anesth. 1197;9:462-6 CR - 2.Scott RP, Saunders DA, Norman J. Propofol: clinical strategies for preventing the pain of injection. 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J Pharmacol Exp Ther. 1991;259:712-8 CR - 30.Newcombe GN. The effect, on injection pain, of adding lignocaine to propofol. Anaesth Intensive Care. 1990; 18:105-7 UR - http://dergipark.org.tr/tr/pub/gantepmj/issue//86207 L1 - http://dergipark.org.tr/tr/download/article-file/73675 ER -