@article{article_866876, title={MOLECULAR BASIS AND INTEGRATIVE ANALYSIS OF Rv1463 AS PROBABLE CONSERVED ATP-BINDING PROTEIN BY COMPUTATIONAL APPROACH}, journal={Journal of Faculty of Pharmacy of Ankara University}, volume={45}, pages={212–226}, year={2021}, DOI={10.33483/jfpau.866876}, author={Beg, Md Amjad and Sevindik, Mustafa and Haider, Shahid and Soni, Preeti and Bhatia, Priya and Hasan, Shahzul and Yadav, Richa and Athar, Fareeda}, keywords={Moleküler kenetlenme, Mycobacterium tuberculosis, rv1463, tüberküloz}, abstract={<div style="text-align:justify;"> <span style="font-size:12px;"> <b>Objective: </b> <i>Tuberculosis as a global epidemic since years due to vigorously changing dynamics of its causal pathogen, Mycobacterium tuberculosis H37Rv (M. tuberculosis). This pathogen has worsened the situation therefore making it so challenging and hard to overcome. In this manuscript, we have used the computational approaches for ATP-binding protein of Mycobacterium tuberculosis H37Rv (M. tuberculosis) that helps in transportation of metal ion across the plasma membranes and resultant generating an electrochemical gradient. Rv1463 a hypothetical protein possessing ATP binding motif (WalkerA) (GXXXXGKS/T), and (Walker B) (DEXXXXXD) and significance of these motifs in ATP binding and hydrolyzing activities. It shows the ATP-binding property by interacting with transcriptional regulatory protein and showing the interacted compounds as magnesium (Mg) and Adenosine di phosphate (ADP). </i> </span> </div> <span style="font-size:12px;"> </span> <div style="text-align:justify;"> <b>Material and Method: </b> <i>The structure of Rv1463 has been build by the Swiss Model webserver and molecular docking was done using AutoDock. </i> </div> <span style="font-size:12px;"> </span> <div style="text-align:justify;"> <b>Result and Discussion: </b> <i> In the mutational analysis which confirms that D175 residues was common in all interactions which may change the protein conformation. These computational approaches can be helpful in developing new strategies in treatment of this disease. </i> </div>}, number={2}, publisher={Ankara Üniversitesi}