TY  - JOUR
T1  - BK Virus Pneumonia with CMV Colitis in a Kidney Transplant Recipient: Successful Treatment with Non-Cidofovir Based Therapy
AU  - Chaitou, Ali R.
AU  - Nasser, Mouhamad
AU  - Karnıb, Hussein
AU  - Hamieh, Amal
PY  - 2021
DA  - March
DO  - 10.5799/jmid.897222
JF  - Journal of Microbiology and Infectious Diseases
JO  - J Microbil Infect Dis
PB  - Aydın ECE
WT  - DergiPark
SN  - 2146-3158
SP  - 36
EP  - 41
VL  - 11
IS  - 01
LA  - en
AB  - BK virus (BKV) pneumonia is a rare entity especially seen in immunosuppressed patients, for which cidofovir is the used treatment option. We describe a case of a young female patient who presented for altered kidney function six months following kidney transplantation for focal segmental glomerulosclerosis and was found to have BKV nephritis.  Her in-hospital stay was complicated by BKV pneumonia requiring mechanical ventilation, in addition to CMV colitis. She was treated with leflunomide/ciprofloxacin and ganciclovir for her pneumonia and colitis, respectively. The patient improved clinically except that her kidney function deteriorated. Leflunomide/ciprofloxacin combination may constitute an effective and safe alternative to cidofovir for the treatment of BKV pneumonia, in particular when cidofovir is not available. J Microbiol Infect Dis 2021; 11(1):36-41.
KW  - BK virus pneumonia
KW  - CMV colitis
KW  - Kidney transplantation
KW  - Leflunomide
KW  - Ciprofloxacin
CR  - 1. 	Reploeg MD, Storch GA, Clifford DB. Bk virus: a clinical review. Clin Infect Dis an Off Publ Infect Dis Soc Am. 2001;33(2):191-202.
CR  - 2. 	Park SB, Kwak JH, Lee KT, et al. Polyoma Virus-Associated Nephropathy and Concurrent Cytomegalovirus Infection in the Kidney Transplant Recipients. Transplant Proc. 2006; 38(7):2059-2061.
CR  - 3. 	Cordero E, Casasola C, Ecarma R, Danguilan R. Cytomegalovirus disease in kidney transplant recipients: incidence, clinical profile, and risk factors. Transplant Proc. 2012;44(3):694-700.
CR  - 4. 	Hariharan S. BK virus nephritis after renal transplantation. Kidney Int. 2006;69(4):655-662.
CR  - 5. 	Yapa HMN, McLornan DP, Raj K, et al. Pneumonitis post-haematopoeitic stem cell transplant - cytopathology clinches diagnosis. J Clin Virol Off Publ Pan Am Soc Clin Virol. 2012;55(3):278-281.
CR  - 6. 	Yoshimura A, Tsuji T, Kawaji Y, Hirakawa Y, Uchiyama H, Hiraoka N. BK virus pneumonia following stem cell transplantation against diffuse large B-cell lymphoma. Respirol case reports. 2018;6(7): e00348.
CR  - 7. 	Hirsch HH, Knowles W, Dickenmann M, et al. Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients. N Engl J Med. 2002;347(7):488-496.
CR  - 8. 	Galan A, Rauch CA, Otis CN. Fatal BK polyoma viral pneumonia associated with immunosuppression. Hum Pathol. 2005;36(9):1031-1034.
CR  - 9. 	Blazquez-Navarro A, Dang-Heine C, Wittenbrink N, et al. BKV, CMV, and EBV Interactions and their Effect on Graft Function One Year Post-Renal Transplantation: Results from a Large Multi-Centre Study. EBioMedicine. 2018; 34:113-121.
CR  - 10. 	Sandler ES, Aquino VM, Goss-Shohet E, Hinrichs S, Krisher K. BK papova virus pneumonia following hematopoietic stem cell transplantation. Bone Marrow Transplant. 1997;20(2):163-165.
CR  - 11. 	Toyoda M, Puliyanda DP, Amet N, et al. Co-infection of polyomavirus-BK and cytomegalovirus in renal transplant recipients. Transplantation. 2005;80(2):198-205.
CR  - 12. 	Akazawa Y, Terada Y, Yamane T, et al. Fatal BK virus pneumonia following stem cell transplantation. Transpl Infect Dis. 2012;14(6):E142-6.
CR  - 13. 	Zaman RA, Ettenger RB, Cheam H, Malekzadeh MH, Tsai EW. A novel treatment regimen for BK viremia. Transplantation. 2014;97(11):1166-1171.
UR  - https://doi.org/10.5799/jmid.897222
L1  - https://dergipark.org.tr/tr/download/article-file/1639947
ER  -