TY - JOUR T1 - Erianinin HT29 Kolorektal Kanser Hücrelerinin Proliferasyonu ve Koloni Oluşumu Üzerine Etkilerinin Araştırılması TT - Investigation of the effects of erianin on proliferation and colony formation of HT29 colorectal cancer cells AU - Serter Koçoğlu, Sema AU - Elmas, Levent AU - Seçme, Mücahit PY - 2021 DA - August Y2 - 2021 DO - 10.32708/uutfd.917751 JF - Journal of Uludağ University Medical Faculty JO - Uludağ Tıp Derg PB - Bursa Uludağ Üniversitesi WT - DergiPark SN - 1300-414X SP - 219 EP - 223 VL - 47 IS - 2 LA - tr AB - Kolorektal kanser, dünyada kanser ilişkili ölümlerin en yaygın dördüncü sebebidir. Erianin antioksidan ve anti-tümör etkilere sahip Dendrobium ekstraktından elde edilen yeni bir dibenzil bileşiğidir. Bu çalışmada, erianinin HT29 kolorektal kanser hücreleri üzerine olan terapötik etkileri araştırılmıştır. Erianinin HT29 hücre canlılığı üzerine etkileri XTT test ile koloni oluşumu üzerine etkileri ise koloni formasyonu ile değerlendirilmiştir. Erianinin HT29 hücrelerinde IC50 değeri 48. saatte 59.05 μM olarak belirlenmiştir. HT29 hücre dizisinde erianin uygulanan grupta koloni sayısı 67±33 iken kontrol grubunda 350±89 olarak hesaplanmıştır. Erianin, HT29 kolorektal kanser hücrelerinde koloni oluşumunu ise anlamlı derecede azaltmıştır. Yapılan çalışmaların sonuçları, erianinin kolorektal kanser tedavisinde doğal elde edilen bir bileşik olarak güvenli, kolay ulaşılabilir ve umut veren terapötik bir ilaç olabileceğini destekler niteliktedir. Gelecekte erianinin kolorektal kanser hücreleri üzerindeki etki mekanizmasını aydınlatacak daha kapsamlı ve çok merkezli desteklenecek ileri düzeyde klinik çalışmalara ihtiyaç vardır. KW - erianin KW - HT29 KW - kolorektal kanser N2 - Colorectal cancer (CRC) is the 4th most common cause of cancer-related death in the global world. Erianin, a novel dibenzyl compound in Dendrobium extract, has antioxidative and antitumor activities. 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