@article{article_947457, title={Epigenetic Changes in Medulloblastoma: Correlation with Molecular Subclassification}, journal={IZTU Journal of Medical and Health Sciences}, volume={1}, pages={35–46}, year={2022}, author={Kanıt, Naz and Özer, Erdener}, keywords={medulloblastom, DNA metilasyonu, histon modifikasyonları, kromatin yeniden düzenlenmesi, lncRNA}, abstract={Medulloblastoma is a malignant childhood brain tumor and shows high clinical heterogeneity among patients. Three major molecular categories of MB have been established; WNT activated group, SHH activated group, and non-WNT/non-SHH-activated group. The latter includes Group 3 and Group 4. All groups show different histological features as well as different genetic and epigenetic backgrounds. Genetic basis of the disease has been widely studied in the last decade, however epigenetic basis of the disease has become a trend research area. The epigenetic researches focus on histone modification mechanisms involving some genes such as KDM6A and EZH2, and also PRC2 complex, in addition to variations in ATP-dependent chromatin remodeling complexes, mainly on SWI/SNF complexes. EZH2 is a candidate target gene as its repressors are currently on trial for MB patients. Finally lncRNA, a noncoding RNA is likely to be the most promising subgroup specific marker. Understanding both genetic and epigenetic differences in medulloblastomas, determining subtype-specific alterations and discovering therapeutics that specifically targets those alterations might be valuable for management of this cancer. In this review, we aimed to address the epigenetic mechanisms in medulloblastomas in the light of the current literature and emphasize the relevant unpublished data in our preliminary study.}, number={1}, publisher={İzmir Tınaztepe Üniversitesi}