@article{article_963125, title={Experimental Comparison of Autograft and DBM Flex (Grafton) for Spinal Lumbar Fusion in Rabbits}, journal={Archives of Clinical and Experimental Medicine}, volume={6}, pages={153–157}, year={2021}, DOI={10.25000/acem.963125}, author={Demirel, Cem and Türköz, Dursun and Yilmaz, Tuncay}, keywords={Otogreft, DBM Flex, Demineralize kemik matrisi, Grafton, Spinal füzyon cerrahisi}, abstract={Aim: The choice of graft materials used for spinal fusion possesses a great importance due to their crucial roles in bone remodelling. Autogenous bone grafts are known as the "gold standard" in spinal fusion surgeries. Studies on synthetic graft materials that can be used instead of autogenous bone grafts have gained importance in recent years. The aim of this study was to compare the efficacy of demineralized bone matrix and autograft in the rabbit spinal lumbar fusion (SLF) model. Methods: Twenty New Zealand rabbits were randomly divided into two groups and underwent SLF by using either iliac crest autologous bone graft (Autograft, n=10) or DBM Flex (Grafton, n=10). Eight-weeks after surgery, animals were sacrificed and spinal fusion was evaluated by computerized tomography (CT), manual palpation, macroscopic analyses, and histological assessments. Results: CT results revealed that autograft led to significantly higher fusion scores than DBM Flex (p=0.0004). Mobility was significantly lower in autograft group (p=0.0007). Significantly lower bone formation scores were observed in DBM Flex group compared to autograft group (p <0.0001). Histology of spine in the autograft group was significantly better than DBM Flex group (p=0.0002). Conclusion: Autograft was superior than DBM flex in SLF and autograft will likely to be the “gold standard” in SLF in the future.}, number={3}, publisher={Mustafa HASBAHÇECİ}