@article{article_978808, title={Prognostic factors in vulvar cancer patients: a single center experience}, journal={Pamukkale Medical Journal}, volume={14}, pages={900–907}, year={2021}, DOI={10.31362/patd.978808}, author={Selvi Demirtaş, Gülşah and Dinçer, Fatih and Görgülü, Gökşen and Sancı, Muzaffer and Sayhan, Sevil}, keywords={Vulva Kanseri, adjuvan tedavi, nüks}, abstract={<p>Purpose: Many prognostic factors have been investigated in vulvar cancer patients. In our study, we aimed to <br />compare clinical and pathological prognostic factors and investigate the factors that affect the recurrence and <br />survival in patients with recurrent and non-recurrent squamous cell vulvar cancer. <br />Materials and methods: This retrospective study was conducted in Tepecik Research Hospital, Izmir, Turkey <br />between 1999-2020. The descriptive features, prognostic factors and survival in recurrent patients were <br />evaluated. <br />Results: Tumor invasion depth, surgical margin positivity, lymphovascular space invasion (LVSI), are <br />statistically significant for recurrence (p=0.03, p=0.00, p=0.04). Variables such as age, tumor size, surgical <br />margin distance (mm), tumor localization, presence of metastatic lymph node, operation type (surgery with <br />lymph node dissection) and adjuvant therapy were not found to be statistically significant in terms of recurrent <br />patients with vulvar cancer. There was correlation between recurrence, LVSI, surgical margin positivity, stage <br />and survival in Kaplan Meier survival analysis. <br />Conclusion: As in other studies, many prognostic factors like tumor invasion depth, surgical margin positivity, <br />LVSI are risk factors for recurrence in our study. Stage, LVSI, recurrence, surgical margin positivity were <br />significant factors for survival as well. <br /> </p>}, number={4}, publisher={Pamukkale Üniversitesi}