@article{article_985659, title={A MULTICLASS METHOD FOR THE ANALYSIS OF ANTIBIOTIC RESIDUES IN MILK POWDER AND WHEY POWDER BY UPLC-MS/MS}, journal={Gıda}, volume={47}, pages={25–33}, year={2021}, DOI={10.15237/gida.GD21124}, author={Yavuz, Arzu and Azar, İsmail and Özcan, Ali and Ülkü, Niyazi}, keywords={antibiyotikler, kalıntılar, veteriner ilaçları, UPLC-MS/MS, validasyon, süt tozu, peynir altı suyu tozu, 2002/657/EC}, abstract={<div style="text-align:justify;">An ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) multi-class method was developed and validated for the determination of 27 antibiotic residues from five classes (macrolides, sulfonamids, quinolones, lincosamids, diaminopyrimidines) in milk powder and whey powder which are commonly used as raw material of many products in the food industry. A simple, inexpensive and fast sample preparation based on the extraction of samples with methanol is the main advantage of the validated method. The validation of the method was performed following the requirements outlined in the European Commission Decision 2002/657/EC, which is required procedure for the methods used in analysis of official audits samples in Europe and Turkey. Matrix effect and uncertainties related with sample preparation and instrumental analysis were minimised by using matrix-matched calibration. The method is capable of detecting residues at very low concentrations. </div>}, number={1}, publisher={Gıda Teknolojisi Derneği}, organization={Gıda ve Yem Kontrol Merkez Araştırma Enstitüsü}