TY - JOUR T1 - A fatal side effect of piperacillin/tazobactam use: a case report. AU - Duyan, Murat AU - Günlü, Serhat AU - Sarıdaş, Ali AU - Cander, Basar AU - Solaç, Yıldızhan PY - 2021 DA - December Y2 - 2021 JF - Eurasian Journal of Critical Care JO - Eurasian j Crit Care PB - Acil Tıp Uzmanları Derneği WT - DergiPark SN - 2667-8721 SP - 119 EP - 121 VL - 3 IS - 3 LA - en AB - Drug-induced QT prolongation with T wave inversion is a complex regulatory and clinical problem due to the rarity of this potentially fatal adverse incident. A 68-year-old female patient was receiving piperacillin/tazobactam therapy for a complicated urinary tract infection. She has had normal ECG findings before the antibacterial therapy. After the treatment, the patient worsens due to long QT which is predisposed to torsades de pointes. As a result of the researches, it was understood that the cause of long QT was piperacillin/tazobactam. We aimed to present a rare case in which we detected drug-induced QTc prolongation with piperacillin/tazobactam in clinical practice. KW - torsades de pointes KW - drug-induced long QT syndrome KW - piperacillin/tazobactam KW - t-wave inversion KW - urinary tract infection KW - arrest CR - :1. Goldenberg I, Moss AJ, Zareba W. QT interval: how to measure it and what is "normal". J Cardiovasc Electrophysiol. 2006;17(3):333-336. doi:10.1111/j.1540-8167.2006.00408.x CR - 2. Antzelevitch C, Shimizu W. Cellular mechanisms underlying the long QT syndrome. Curr Opin Cardiol. 2002;17(1):43-51. doi:10.1097/00001573-200201000-00007 CR - 3. Woosley RL. QT Drug Lists by Risk Groups. AZ: Arizona Center for Research and Education on Therapeutics. Published 2009. Accessed September 1, 2021. http:// www.azcert.org/medical-pros/drug-lists/drug-lists.cfm CR - 4. Katchman AN, Koerner J, Tosaka T, Woosley RL, Ebert SN. Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs. J Pharmacol Exp Ther. 2006;316(3):1098-1106. doi:10.1124/jpet.105.093393 CR - 5. Poluzzi E, Raschi E, Motola D, Moretti U, De Ponti F. Antimicrobials and the risk of torsades de pointes: the contribution from data mining of the US FDA Adverse Event Reporting System. Drug Saf. 2010;33(4):303-314. doi:10.2165/11531850-000000000-00000 CR - 6. Panduranga P, Al-Mukhaini M, Rajarao MP. Multi-factorial causes of torsade de pointes in a hospitalised surgical patient. Sultan Qaboos Univ Med J. 2013;13(1):152-155. doi:10.12816/0003211 CR - 7. Piperacillin and tazobactam: Drug information. Published December 6, 2020. Accessed semtember 1, 2021. . https://www.uptodate.com/contents/piperacillin-and-tazobactam-drug-information search=piperacillin%20tazobactam&source=panel_search_result&selectedTitle=1~104&usage_type=panel&kp_tab=drug_general&display_rank=1#F210382 UR - https://dergipark.org.tr/tr/pub/ejcc/issue//992697 L1 - https://dergipark.org.tr/tr/download/article-file/1963337 ER -