Aim: Most of the cases with fetal loss are not associated with chromosomal abnormalities. If there is no another causative factor, cytogenetic analysis may reveal a balanced structural chromosomal rearrangement in any partner. In 3-5% of couples with at least 2 spontaneous abortions, one partner carries a balanced chromosomal rearrangement. The aim of this study is to investigate the balanced structural chromosomal rearrangements and serve the genetic counselling to the family about following gestation.

Material and method: In this study, 80 couples with at least two spontaneous abortions or one spontaneous abortion and one stillborn admitted to the Fırat Medical Center were analysed. Chromosomes were obtained from peripheral blood lymphocytes by standart techniques. Chromosomal abnormalities were confirmed by FISH (fluorescent in-situ hybridisation) technique.

Results: Three chromosomal polymorphic variants including two inv(9), one Yqh+ and one 13/14 Robertsonian translocation chromosome abnormality were found in 80 couples with recurrent spontaneous abortions. Chromosomal abnormality incidence including polymorphic variants in this study was determined to be 5%. These incidences are compatible with the literature.

Conclusion: The evaluation of the chromosomal abnormalities in couples with recurrent spontaneous abortions is very important. These findings are essential to perform appropriate genetic counseling for the future pregnancies of these couples.