Aim: To determine findings of laboratory and clinical in patients with megaloblastic anemia.

Matreial and methods: We retrospectively studied hospitalized patients with megaloblastic anemia in Firat University Medical Faculty, the department of Hematology. Physical examination, complete blood counts, morphologic review, reticulocyte count, serum level of vitamin B₁₂ and folic acid, bone marrow aspiration, gastric evaluation and biopsy with endoscopy were done as diagnostic studies.

Results: Twenty two patients were evaluated in our study. The mean age was 56±16 (16-95). As clinical finding, we detected glossitis in eight cases, ikter in six cases, oral aphthous lesions in two cases, symptomatic diare in one case.We found vitamin B₁₂ deficiency in fifteen cases, folic acid deficiency in four cases, combined deficiency (both vitamin B₁₂ deficiency and folic acid deficiency ) in three cases.

Discussion and conclusion: Vitamin B₁₂ deficiency which is the most common cause of megaloblastic anemia is seen more frequent in older patients. In our study, we found vitamin B₁₂ deficiency as the most common cause of megaloblastic anemia.