Wolfram Syndrome is consists of the combination of diabetes insipidus, type I diabetes mellitus, optic atrophy and hearing loss. Urinary tract anomalies such as hidronefroz, megaureter and sort stature occurs with this sandrome. Here, after following the type I diabetes mellitus diagnosis for a long time, we have diagnosed two DIDMOAD cases.Because precent the delayed diagnosis, all cases with type diabetes mellitus have to examined carefully for optic atrophy and diabetes insipidus.