Abstract
Multiple myeloma MM is a hematological malignity that originates from the bone marrow and is characterized by plasma cells that produce monoclonal immunoglobulin. Cutaneous involvement is very rare in patients with MM. A 73-year-old, male patient, who has a diagnosis of IgG lambda MM, was referred to our clinic from the Department of Internal Medicine due to his skin lesions. The dermatological examination revealed a total of 10 erythematous violaceous-tumoral lesions with a diameter varying between 2-5 cm, on upper extremities, the front and back of the body. The lesions of the patient were considered as cutaneous involvement of MM because histopathological examination of skin biopsy is showed diffuse atypical plasma cell infiltration with lambda monoclonality.
Keywords
References
- Requena L, Kutzner H, Palmedo G, Calonje E, Requena C, Pérez G, Pastor MA, Sangueza OP. Cutaneous involvement in multiple myeloma: a clinicopathologic, immunohistochemical, and cytogenetic study of 8 cases. Arch Dermatol. 2003; 139: 475-86.
- Bayer-Garner IB, Smoller BR. The spectrum of cutaneous disease in multiplemyeloma. J Am Acad Dermatol 2003; 48: 497-507.
- Jegou J, Derancourt C, Coindre JM, Leleu T, Perceau G, Bernard P. Skin location of multiple myeloma mimicking a vascular tumor. Ann Dermatol Venereol. 2001; 128: 753-5.
- Patterson JW, Parsons JM, White RM, Fitz- patrick JE, Kohout-Dutz E. Cutaneous involve- ment of multiple myeloma and extramedullary plasmacytoma. J Am Acad Dermatol 1988; 19: 879-90.
- Shah A, Klimo P, Worth A. Multiple myeloma first observed as multiple cutaneous plasmacy- tomas. Arch Dermatol 1982; 118: 922-4.
Abstract
Multipl myelom MM kemik iliğinden köken alan ve monoklonal immunglobulin üreten plazma hücreleri ile karakterize hematolojik bir malinignitedir. MM’li hastalarda deri tutulumu çok nadir görülmektedir. Yetmiş üç yaşında, IgG lambda MM tanısı olan hasta deri lezyonları nedeniyle Dahiliye bölümü tarafından bölümümüze konsülte edildi. Yapılan dermatolojik muayenede üst ekstremitelerde, gövde ön ve arka yüzde dağınık yerleşimli, çapları 2-5 cm arasında değişen, eritemli viyolase renkte toplam 10 adet tümöral lezyon izlendi. Lezyonlardan alınan biyopsinin histopatolojik incelemesinde lambda monoklonaliteli diffüz atipik plazma hücre infiltrasyonu saptanması nedeniyle hastanın lezyonları MM deri tutulumu olarak değerlendirildi.
Keywords
References
- Requena L, Kutzner H, Palmedo G, Calonje E, Requena C, Pérez G, Pastor MA, Sangueza OP. Cutaneous involvement in multiple myeloma: a clinicopathologic, immunohistochemical, and cytogenetic study of 8 cases. Arch Dermatol. 2003; 139: 475-86.
- Bayer-Garner IB, Smoller BR. The spectrum of cutaneous disease in multiplemyeloma. J Am Acad Dermatol 2003; 48: 497-507.
- Jegou J, Derancourt C, Coindre JM, Leleu T, Perceau G, Bernard P. Skin location of multiple myeloma mimicking a vascular tumor. Ann Dermatol Venereol. 2001; 128: 753-5.
- Patterson JW, Parsons JM, White RM, Fitz- patrick JE, Kohout-Dutz E. Cutaneous involve- ment of multiple myeloma and extramedullary plasmacytoma. J Am Acad Dermatol 1988; 19: 879-90.
- Shah A, Klimo P, Worth A. Multiple myeloma first observed as multiple cutaneous plasmacy- tomas. Arch Dermatol 1982; 118: 922-4.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Case Report |
| Authors | |
| Publication Date | September 1, 2014 |
| Published in Issue | Year 2014 |