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Tedavi Almayan Obsesif Kompulsif Bozukluk Hastalarında Nötrofil / Lenfosit ve Platelet / Lenfosit Oranlarının Değerlendirilmesi

Year 2021, , 360 - 368, 21.12.2021

İsmet Esra Çiçek , Medine Gıynaş Ayhan , Seda Kırcı Ercan , Erdinç Çiçek Ülkü Beşiktepe Ayan İbrahim Eren

https://doi.org/10.47493/abantmedj.883982
Cited By: 1

Abstract

Amaç: Çalışmada tedavisiz obsesif kompulsif bozukluk (OKB) hastalarında nötrofil/lenfosit oranı (NLR) ve platelet/ lenfosit oranının (PLR), sağlıklı kontroller ile karşılaştırılması amaçlanmıştır. Ayrıca içgörü düzeyleri ile NLR ve PLR arasındaki ilişki değerlendirilmiştir.
Gereç ve Yöntemler: Çalışmaya tedavi almayan ardışık 56 OKB hastası ve hasta grubu ile benzer sosyodemografik özelliklere sahip 56 sağlıklı birey, kontrol grubu olarak belirlendi. Hastalar ve kontrol grubu psikiyatrik bozukluklar ve hemogram parametreleri açısından değerlendirildi. Obsesif kompulsif belirtilerin şiddeti ve içgörü düzeyi Yale-Brown Obsesif Kompulsif Ölçeği ile değerlendirildi.
Bulgular: Ortalama OKB başlangıç yaşı 19.54±3.98 yıl, ortalama hastalık süresi 3.90±2.77 yıl olarak bulundu. OKB hastalarında ortalama NLR ve PLR düzeyleri sağlıklı kontrollere göre anlamlı derecede yüksekti. İçgörüsü olmayan veya zayıf olan OKB hastalarında PLR düzeyleri daha yüksek saptandı
Sonuç: Bulgularımıza göre OKB hastalarında NLR, PLR değerlerinin yüksekliği ve içgörüsü yetersiz/olmayan hastalarda PLR yüksekliği etyolojide inflamatuar süreçlerin rolü olabileceğini göstermektedir

Keywords

obsesif kompulsif bozukluk Nötrofil / lenfosit oranı Platelet / lenfosit oranı İnflamasyon

Supporting Institution

Yok

References

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  • Referans2. Ruscio AM, Stein DJ, Chiu WT, Kessler RC. The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication. Mol Psychiatry. 2010;15(1):53-63.
  • Referans3. Alonso P, Menchón JM, Segalàs C, Jaurrieta N, Jiménez-Murcia S, Cardoner N, et al. Clinical implications of insight assessment in obsessive-compulsive disorder. Compr Psychiatry. 2008;49(3):305-12.
  • Referans4. Catapano F, Perris F, Fabrazzo M, Cioffi V, Giacco D, De Santis V, et al. Obsessive–compulsive disorder with poor insight: a three-year prospective study. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(2):323-30.
  • Referans5. Jacob ML, Larson MJ, Storch EA. Insight in adults with obsessive–compulsive disorder. Compr Psychiatry. 2014;55(4):896-903.
  • Referans6. Bellino S, Patria L, Ziero S, Bogetto F. Clinical picture of obsessive-compulsive disorder with poor insight: a regression model. Psychiatry Res. 2005;136(2-3):223-31.
  • Referans7. Eisen JL, Mancebo MA, Pinto A, Coles ME, Pagano ME, Stout R, et al. Impact of obsessive-compulsive disorder on quality of life. Compr Psychiatry. 2006;47(4):270-5.
  • Referans8. Bozorgmehr A, Ghadirivasfi M, Shahsavand Ananloo E. Obsessive–compulsive disorder, which genes? Which functions? Which pathways? An integrated holistic view regarding OCD and its complex genetic etiology. J Neurogenet. 2017;31(3):153-60.
  • Referans9. Wu K, Hanna GL, Rosenberg DR, Arnold PD. The role of glutamate signaling in the pathogenesis and treatment of obsessive–compulsive disorder. Pharmacology Biochemistry and Behavior. 2012;100(4):726-35.
  • Referans10. Westenberg HG, Fineberg NA, Denys D. Neurobiology of obsessive-compulsive disorder: serotonin and beyond. CNS spectrums. 2007;12(S3):14-27.
  • Referans11. Adams TG, Kelmendi B, Brake CA, Gruner P, Badour CL, Pittenger C. The role of stress in the pathogenesis and maintenance of obsessive-compulsive disorder. Chronic Stress. 2018;2:2470547018758043.
  • Referans12. Abramowitz JS, Arch JJ. Strategies for improving long-term outcomes in cognitive behavioral therapy for obsessive-compulsive disorder: Insights from learning theory. Cogn Behav Pract. 2014;21(1):20-31.
  • Referans13. da Rocha FF, Correa H, Teixeira AL. Obsessive-compulsive disorder and immunology: a review. Progress in neuro-psychopharmacology & biological psychiatry. 2008;32(5):1139-46.
  • Referans14. Erbay LG, Kavuran NA, Taşkapan Ç, Lara Utku İ, Yoloğlu S, Temelli HG, et al. Serum IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ levels in drug-free, comorbidity-free obsessive-compulsive disorder patients. Anatolian Journal of Psychiatry. 2018;19(2):157-62.
  • Referans15. Swedo SE, Grant PJ. Annotation: PANDAS: a model for human autoimmune disease. J Child Psychol Psychiatry. 2005;46(3):227-34.
  • Referans16. Korostil M, Feinstein A. Anxiety disorders and their clinical correlates in multiple sclerosis patients. Multiple Sclerosis Journal. 2007;13(1):67-72.
  • Referans17. Bachen EA, Chesney MA, Criswell LA. Prevalence of mood and anxiety disorders in women with systemic lupus erythematosus. Arthritis Care & Research: Official Journal of the American College of Rheumatology. 2009;61(6):822-9.
  • Referans18. Mataix-Cols D, Frans E, Pérez-Vigil A, Kuja-Halkola R, Gromark C, Isomura K, et al. A total-population multigenerational family clustering study of autoimmune diseases in obsessive–compulsive disorder and Tourette’s/chronic tic disorders. Mol Psychiatry. 2018;23(7):1652-8.
  • Referans19. Denys D, Fluitman S, Kavelaars A, Heijnen C, Westenberg H. Decreased TNF-α and NK activity in obsessive-compulsive disorder. Psychoneuroendocrinology. 2004;29(7):945-52.
  • Referans20. Konuk N, Tekın I, Ozturk U, Atik L, Atasoy N, Bektas S, et al. Plasma levels of tumor necrosis factor-alpha and interleukin-6 in obsessive compulsive disorder. Mediators of inflammation. 2007;2007.
  • Referans21. Fluitman SB, Denys DA, Heijnen CJ, Westenberg HG. Disgust affects TNF-α, IL-6 and noradrenalin levels in patients with obsessive–compulsive disorder. Psychoneuroendocrinology. 2010;35(6):906-11.
  • Referans22. Gray SM, Bloch MH. Systematic review of proinflammatory cytokines in obsessive-compulsive disorder. Current psychiatry reports. 2012;14(3):220-8.
  • Referans23. Balta S, Ozturk C. The platelet-lymphocyte ratio: A simple, inexpensive and rapid prognostic marker for cardiovascular events. Platelets. 2014(0):1-2.
  • Referans24. Zahorec R. Ratio of neutrophil to lymphocyte counts-rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001;102(1):5-14.
  • Referans25. Puppe B, Tuchscherer M, Tuchscherer A. The effect of housing conditions and social environment immediately after weaning on the agonistic behaviour, neutrophil/lymphocyte ratio, and plasma glucose level in pigs. Livestock Production Science. 1997;48(2):157-64.
  • Referans26. Trevisi E, Bertoni G. Some physiological and biochemical methods for acute and chronic stress evaluation in dairy cows. Italian Journal of Animal Science. 2009;8(1s):265-86.
  • Referans27. Kuyumcu ME, Yesil Y, Ozturk ZA, Kizilarslanoglu C, Etgul S, Halil M, et al. The evaluation of neutrophil-lymphocyte ratio in Alzheimer's disease. Dement Geriatr Cogn Disord. 2012;34(2):69-74.
  • Referans28. Semiz M, Yildirim O, Canan F, Demir S, Hasbek E, Tuman TC, et al. Elevated neutrophil/lymphocyte ratio in patients with schizophrenia. Psychiatria Danubina. 2014;26(3):220-5.
  • Referans29. Kalelioglu T, Akkus M, Karamustafalioglu N, Genc A, Genc ES, Cansiz A, et al. Neutrophil-lymphocyte and platelet-lymphocyte ratios as inflammation markers for bipolar disorder. Psychiatry Res. 2015;228(3):925-7.
  • Referans30. Cıcek E, Demırel B, Cıcek IE, Kıraç AS, Eren I. Increased neutrophil-lymphocyte and platelet-lymphocyte ratios in male heroin addicts: a prospective controlled study. Clinical Psychopharmacology and Neuroscience. 2018;16(2):190.
  • Referans31. Uzun AD, Sapmaz ŞY, Çakır B, Kandemir H. Could neutrophil-to-lymphocyte ratio be an important parameter in children and adoles-cents with obsessive compulsive disorder? Turkish J Clinical Psychiatry. 2020;23:101-5.
  • Referans32. Uçar HN, Murat D, Eray Ş. Simple peripheral markers for inflammation in drug-naive, comorbidity-free adolescents with obsessive-compulsive disorder. Eastern Journal of Medicine. 2019;24(1):23-9.
  • Referans33. Özyurt G, Binici NC. The neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in adolescent obsessive-compulsive disorder: Does comorbid anxiety disorder affect inflammatory response? Psychiatry Res. 2019;272:311-5.
  • Referans34. Herdi O, Sayar-Akaslan D, İlhan RS, Çolak B, Duman B. Associations Between Subclinical Inflammatory Markers and OCD: A Retrospective Study. Psychiatry Res. 2020;290:113065.
  • Referans35. Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, et al. The Yale-Brown obsessive compulsive scale: I. Development, use, and reliability. Archives of general psychiatry. 1989;46(11):1006-11.
  • Referans36. Karamustafalıoğlu O, Üçışık A, Ulusoy M, Erkmen H, editors. Yale-Brown obsesyon-kompulsiyon derecelendirme ölçeğinin geçerlilik ve güvenirlik çalışması. National Psychiatry Congress; 1993.
  • Referans37. Gray SM, Bloch MH. Systematic review of proinflammatory cytokines in obsessive-compulsive disorder. Current psychiatry reports. 2012;14(3):220-8.
  • Referans38. Rao NP, Venkatasubramanian G, Ravi V, Kalmady S, Cherian A. Plasma cytokine abnormalities in drug-naïve, comorbidity-free obsessive–compulsive disorder. Psychiatry Res. 2015;229(3):949-52.
  • Referans39. Schwartz RS, Borissoff JI, Spronk HM, ten Cate H. The hemostatic system as a modulator of atherosclerosis. N Engl J Med. 2011;364(18):1746-60.
  • Referans40. Projahn D, Koenen RR. Platelets: key players in vascular inflammation. J Leukoc Biol. 2012;92(6):1167-75.
  • Referans41. Ekinci O. Obsesif kompulsif bozukluk hastalarinda düsük dereceli inflamasyonla klinik ve sosyodemografik özellikler arasindaki iliski. Anadolu Psikiyatri Dergisi. 2016;17:12.
  • Referans42. Moody G, Miller BJ. Total and differential white blood cell counts and hemodynamic parameters in first-episode psychosis. Psychiatry Res. 2018;260:307-12.
  • Referans43. Melo MCA, Garcia RF, de Araújo CFC, Abreu RLC, de Bruin PFC, de Bruin VMS. Clinical significance of neutrophil-lymphocyte and platelet-lymphocyte ratios in bipolar patients: an 18-month prospective study. Psychiatry Res. 2019;271:8-14.
  • Referans44. Kayhan F, Gündüz Ş, Ersoy SA, Kandeğer A, Annagür BB. Relationships of neutrophil–lymphocyte and platelet–lymphocyte ratios with the severity of major depression. Psychiatry Res. 2017;247:332-5.
  • Referans45. Turkmen K, Erdur FM, Ozcicek F, Ozcicek A, Akbas EM, Ozbicer A, et al. Platelet‐to‐lymphocyte ratio better predicts inflammation than neutrophil‐to‐lymphocyte ratio in end‐stage renal disease patients. Hemodialysis International. 2013;17(3):391-6.
  • Referans46. Yaprak M, Turan MN, Dayanan R, Akın S, Değirmen E, Yıldırım M, et al. Platelet-to-lymphocyte ratio predicts mortality better than neutrophil-to-lymphocyte ratio in hemodialysis patients. Int Urol Nephrol. 2016;48(8):1343-8.

Evaluation of Neutrophil / Lymphocyte and Platelet / Lymphocyte Ratios in Patients with Untreated Obsessive Compulsive Disorder

Year 2021, , 360 - 368, 21.12.2021

İsmet Esra Çiçek , Medine Gıynaş Ayhan , Seda Kırcı Ercan , Erdinç Çiçek Ülkü Beşiktepe Ayan İbrahim Eren

https://doi.org/10.47493/abantmedj.883982
Cited By: 1

Abstract

References

  • Referans1. Association AP. Diagnostic and statistical manual of mental disorders (DSM-5®): American Psychiatric Pub; 2013.
  • Referans2. Ruscio AM, Stein DJ, Chiu WT, Kessler RC. The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication. Mol Psychiatry. 2010;15(1):53-63.
  • Referans3. Alonso P, Menchón JM, Segalàs C, Jaurrieta N, Jiménez-Murcia S, Cardoner N, et al. Clinical implications of insight assessment in obsessive-compulsive disorder. Compr Psychiatry. 2008;49(3):305-12.
  • Referans4. Catapano F, Perris F, Fabrazzo M, Cioffi V, Giacco D, De Santis V, et al. Obsessive–compulsive disorder with poor insight: a three-year prospective study. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(2):323-30.
  • Referans5. Jacob ML, Larson MJ, Storch EA. Insight in adults with obsessive–compulsive disorder. Compr Psychiatry. 2014;55(4):896-903.
  • Referans6. Bellino S, Patria L, Ziero S, Bogetto F. Clinical picture of obsessive-compulsive disorder with poor insight: a regression model. Psychiatry Res. 2005;136(2-3):223-31.
  • Referans7. Eisen JL, Mancebo MA, Pinto A, Coles ME, Pagano ME, Stout R, et al. Impact of obsessive-compulsive disorder on quality of life. Compr Psychiatry. 2006;47(4):270-5.
  • Referans8. Bozorgmehr A, Ghadirivasfi M, Shahsavand Ananloo E. Obsessive–compulsive disorder, which genes? Which functions? Which pathways? An integrated holistic view regarding OCD and its complex genetic etiology. J Neurogenet. 2017;31(3):153-60.
  • Referans9. Wu K, Hanna GL, Rosenberg DR, Arnold PD. The role of glutamate signaling in the pathogenesis and treatment of obsessive–compulsive disorder. Pharmacology Biochemistry and Behavior. 2012;100(4):726-35.
  • Referans10. Westenberg HG, Fineberg NA, Denys D. Neurobiology of obsessive-compulsive disorder: serotonin and beyond. CNS spectrums. 2007;12(S3):14-27.
  • Referans11. Adams TG, Kelmendi B, Brake CA, Gruner P, Badour CL, Pittenger C. The role of stress in the pathogenesis and maintenance of obsessive-compulsive disorder. Chronic Stress. 2018;2:2470547018758043.
  • Referans12. Abramowitz JS, Arch JJ. Strategies for improving long-term outcomes in cognitive behavioral therapy for obsessive-compulsive disorder: Insights from learning theory. Cogn Behav Pract. 2014;21(1):20-31.
  • Referans13. da Rocha FF, Correa H, Teixeira AL. Obsessive-compulsive disorder and immunology: a review. Progress in neuro-psychopharmacology & biological psychiatry. 2008;32(5):1139-46.
  • Referans14. Erbay LG, Kavuran NA, Taşkapan Ç, Lara Utku İ, Yoloğlu S, Temelli HG, et al. Serum IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ levels in drug-free, comorbidity-free obsessive-compulsive disorder patients. Anatolian Journal of Psychiatry. 2018;19(2):157-62.
  • Referans15. Swedo SE, Grant PJ. Annotation: PANDAS: a model for human autoimmune disease. J Child Psychol Psychiatry. 2005;46(3):227-34.
  • Referans16. Korostil M, Feinstein A. Anxiety disorders and their clinical correlates in multiple sclerosis patients. Multiple Sclerosis Journal. 2007;13(1):67-72.
  • Referans17. Bachen EA, Chesney MA, Criswell LA. Prevalence of mood and anxiety disorders in women with systemic lupus erythematosus. Arthritis Care & Research: Official Journal of the American College of Rheumatology. 2009;61(6):822-9.
  • Referans18. Mataix-Cols D, Frans E, Pérez-Vigil A, Kuja-Halkola R, Gromark C, Isomura K, et al. A total-population multigenerational family clustering study of autoimmune diseases in obsessive–compulsive disorder and Tourette’s/chronic tic disorders. Mol Psychiatry. 2018;23(7):1652-8.
  • Referans19. Denys D, Fluitman S, Kavelaars A, Heijnen C, Westenberg H. Decreased TNF-α and NK activity in obsessive-compulsive disorder. Psychoneuroendocrinology. 2004;29(7):945-52.
  • Referans20. Konuk N, Tekın I, Ozturk U, Atik L, Atasoy N, Bektas S, et al. Plasma levels of tumor necrosis factor-alpha and interleukin-6 in obsessive compulsive disorder. Mediators of inflammation. 2007;2007.
  • Referans21. Fluitman SB, Denys DA, Heijnen CJ, Westenberg HG. Disgust affects TNF-α, IL-6 and noradrenalin levels in patients with obsessive–compulsive disorder. Psychoneuroendocrinology. 2010;35(6):906-11.
  • Referans22. Gray SM, Bloch MH. Systematic review of proinflammatory cytokines in obsessive-compulsive disorder. Current psychiatry reports. 2012;14(3):220-8.
  • Referans23. Balta S, Ozturk C. The platelet-lymphocyte ratio: A simple, inexpensive and rapid prognostic marker for cardiovascular events. Platelets. 2014(0):1-2.
  • Referans24. Zahorec R. Ratio of neutrophil to lymphocyte counts-rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001;102(1):5-14.
  • Referans25. Puppe B, Tuchscherer M, Tuchscherer A. The effect of housing conditions and social environment immediately after weaning on the agonistic behaviour, neutrophil/lymphocyte ratio, and plasma glucose level in pigs. Livestock Production Science. 1997;48(2):157-64.
  • Referans26. Trevisi E, Bertoni G. Some physiological and biochemical methods for acute and chronic stress evaluation in dairy cows. Italian Journal of Animal Science. 2009;8(1s):265-86.
  • Referans27. Kuyumcu ME, Yesil Y, Ozturk ZA, Kizilarslanoglu C, Etgul S, Halil M, et al. The evaluation of neutrophil-lymphocyte ratio in Alzheimer's disease. Dement Geriatr Cogn Disord. 2012;34(2):69-74.
  • Referans28. Semiz M, Yildirim O, Canan F, Demir S, Hasbek E, Tuman TC, et al. Elevated neutrophil/lymphocyte ratio in patients with schizophrenia. Psychiatria Danubina. 2014;26(3):220-5.
  • Referans29. Kalelioglu T, Akkus M, Karamustafalioglu N, Genc A, Genc ES, Cansiz A, et al. Neutrophil-lymphocyte and platelet-lymphocyte ratios as inflammation markers for bipolar disorder. Psychiatry Res. 2015;228(3):925-7.
  • Referans30. Cıcek E, Demırel B, Cıcek IE, Kıraç AS, Eren I. Increased neutrophil-lymphocyte and platelet-lymphocyte ratios in male heroin addicts: a prospective controlled study. Clinical Psychopharmacology and Neuroscience. 2018;16(2):190.
  • Referans31. Uzun AD, Sapmaz ŞY, Çakır B, Kandemir H. Could neutrophil-to-lymphocyte ratio be an important parameter in children and adoles-cents with obsessive compulsive disorder? Turkish J Clinical Psychiatry. 2020;23:101-5.
  • Referans32. Uçar HN, Murat D, Eray Ş. Simple peripheral markers for inflammation in drug-naive, comorbidity-free adolescents with obsessive-compulsive disorder. Eastern Journal of Medicine. 2019;24(1):23-9.
  • Referans33. Özyurt G, Binici NC. The neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in adolescent obsessive-compulsive disorder: Does comorbid anxiety disorder affect inflammatory response? Psychiatry Res. 2019;272:311-5.
  • Referans34. Herdi O, Sayar-Akaslan D, İlhan RS, Çolak B, Duman B. Associations Between Subclinical Inflammatory Markers and OCD: A Retrospective Study. Psychiatry Res. 2020;290:113065.
  • Referans35. Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, et al. The Yale-Brown obsessive compulsive scale: I. Development, use, and reliability. Archives of general psychiatry. 1989;46(11):1006-11.
  • Referans36. Karamustafalıoğlu O, Üçışık A, Ulusoy M, Erkmen H, editors. Yale-Brown obsesyon-kompulsiyon derecelendirme ölçeğinin geçerlilik ve güvenirlik çalışması. National Psychiatry Congress; 1993.
  • Referans37. Gray SM, Bloch MH. Systematic review of proinflammatory cytokines in obsessive-compulsive disorder. Current psychiatry reports. 2012;14(3):220-8.
  • Referans38. Rao NP, Venkatasubramanian G, Ravi V, Kalmady S, Cherian A. Plasma cytokine abnormalities in drug-naïve, comorbidity-free obsessive–compulsive disorder. Psychiatry Res. 2015;229(3):949-52.
  • Referans39. Schwartz RS, Borissoff JI, Spronk HM, ten Cate H. The hemostatic system as a modulator of atherosclerosis. N Engl J Med. 2011;364(18):1746-60.
  • Referans40. Projahn D, Koenen RR. Platelets: key players in vascular inflammation. J Leukoc Biol. 2012;92(6):1167-75.
  • Referans41. Ekinci O. Obsesif kompulsif bozukluk hastalarinda düsük dereceli inflamasyonla klinik ve sosyodemografik özellikler arasindaki iliski. Anadolu Psikiyatri Dergisi. 2016;17:12.
  • Referans42. Moody G, Miller BJ. Total and differential white blood cell counts and hemodynamic parameters in first-episode psychosis. Psychiatry Res. 2018;260:307-12.
  • Referans43. Melo MCA, Garcia RF, de Araújo CFC, Abreu RLC, de Bruin PFC, de Bruin VMS. Clinical significance of neutrophil-lymphocyte and platelet-lymphocyte ratios in bipolar patients: an 18-month prospective study. Psychiatry Res. 2019;271:8-14.
  • Referans44. Kayhan F, Gündüz Ş, Ersoy SA, Kandeğer A, Annagür BB. Relationships of neutrophil–lymphocyte and platelet–lymphocyte ratios with the severity of major depression. Psychiatry Res. 2017;247:332-5.
  • Referans45. Turkmen K, Erdur FM, Ozcicek F, Ozcicek A, Akbas EM, Ozbicer A, et al. Platelet‐to‐lymphocyte ratio better predicts inflammation than neutrophil‐to‐lymphocyte ratio in end‐stage renal disease patients. Hemodialysis International. 2013;17(3):391-6.
  • Referans46. Yaprak M, Turan MN, Dayanan R, Akın S, Değirmen E, Yıldırım M, et al. Platelet-to-lymphocyte ratio predicts mortality better than neutrophil-to-lymphocyte ratio in hemodialysis patients. Int Urol Nephrol. 2016;48(8):1343-8.
There are 46 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Research Articles
Authors

İsmet Esra Çiçek 0000-0001-6176-0095

Medine Gıynaş Ayhan 0000-0002-7127-8929

Seda Kırcı Ercan 0000-0002-1363-0349

Erdinç Çiçek This is me 0000-0002-1477-810X

Ülkü Beşiktepe Ayan This is me 0000-0003-1047-5619

İbrahim Eren 0000-0003-1626-7810

Publication Date December 21, 2021
Submission Date February 20, 2021
Published in Issue Year 2021

Cite

APA Çiçek, İ. E., Gıynaş Ayhan, M., Kırcı Ercan, S., Çiçek, E., et al. (2021). Tedavi Almayan Obsesif Kompulsif Bozukluk Hastalarında Nötrofil / Lenfosit ve Platelet / Lenfosit Oranlarının Değerlendirilmesi. Abant Medical Journal, 10(3), 360-368. https://doi.org/10.47493/abantmedj.883982
AMA Çiçek İE, Gıynaş Ayhan M, Kırcı Ercan S, Çiçek E, Beşiktepe Ayan Ü, Eren İ. Tedavi Almayan Obsesif Kompulsif Bozukluk Hastalarında Nötrofil / Lenfosit ve Platelet / Lenfosit Oranlarının Değerlendirilmesi. Abant Med J. December 2021;10(3):360-368. doi:10.47493/abantmedj.883982
Chicago Çiçek, İsmet Esra, Medine Gıynaş Ayhan, Seda Kırcı Ercan, Erdinç Çiçek, Ülkü Beşiktepe Ayan, and İbrahim Eren. “Tedavi Almayan Obsesif Kompulsif Bozukluk Hastalarında Nötrofil / Lenfosit Ve Platelet / Lenfosit Oranlarının Değerlendirilmesi”. Abant Medical Journal 10, no. 3 (December 2021): 360-68. https://doi.org/10.47493/abantmedj.883982.
EndNote Çiçek İE, Gıynaş Ayhan M, Kırcı Ercan S, Çiçek E, Beşiktepe Ayan Ü, Eren İ (December 1, 2021) Tedavi Almayan Obsesif Kompulsif Bozukluk Hastalarında Nötrofil / Lenfosit ve Platelet / Lenfosit Oranlarının Değerlendirilmesi. Abant Medical Journal 10 3 360–368.
IEEE İ. E. Çiçek, M. Gıynaş Ayhan, S. Kırcı Ercan, E. Çiçek, Ü. Beşiktepe Ayan, and İ. Eren, “Tedavi Almayan Obsesif Kompulsif Bozukluk Hastalarında Nötrofil / Lenfosit ve Platelet / Lenfosit Oranlarının Değerlendirilmesi”, Abant Med J, vol. 10, no. 3, pp. 360–368, 2021, doi: 10.47493/abantmedj.883982.
ISNAD Çiçek, İsmet Esra et al. “Tedavi Almayan Obsesif Kompulsif Bozukluk Hastalarında Nötrofil / Lenfosit Ve Platelet / Lenfosit Oranlarının Değerlendirilmesi”. Abant Medical Journal 10/3 (December 2021), 360-368. https://doi.org/10.47493/abantmedj.883982.
JAMA Çiçek İE, Gıynaş Ayhan M, Kırcı Ercan S, Çiçek E, Beşiktepe Ayan Ü, Eren İ. Tedavi Almayan Obsesif Kompulsif Bozukluk Hastalarında Nötrofil / Lenfosit ve Platelet / Lenfosit Oranlarının Değerlendirilmesi. Abant Med J. 2021;10:360–368.
MLA Çiçek, İsmet Esra et al. “Tedavi Almayan Obsesif Kompulsif Bozukluk Hastalarında Nötrofil / Lenfosit Ve Platelet / Lenfosit Oranlarının Değerlendirilmesi”. Abant Medical Journal, vol. 10, no. 3, 2021, pp. 360-8, doi:10.47493/abantmedj.883982.
Vancouver Çiçek İE, Gıynaş Ayhan M, Kırcı Ercan S, Çiçek E, Beşiktepe Ayan Ü, Eren İ. Tedavi Almayan Obsesif Kompulsif Bozukluk Hastalarında Nötrofil / Lenfosit ve Platelet / Lenfosit Oranlarının Değerlendirilmesi. Abant Med J. 2021;10(3):360-8.

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