Prevalence and density of Demodex mites (Acari: Demodecidae) in patients with seborrheic dermatitis
Yıl 2022,
, 54 - 60, 28.07.2022
Erhan Zeytun
,
Mustafa Yazıcı
Öz
This study was conducted to determine the prevalence and density of Demodex mites in patients with seborrheic dermatitis. The study included 37 patients and 35 healthy controls who were diagnosed with seborrheic dermatitis by clinical examination. The sample materials were taken from the cheek, nasolabial and jaw areas of the participants using the standard superficial skin biopsy method and examined for the presence and number of Demodex mites under light microscopy. Demodex spp. mites were detected in 34 (91.9%) of the patients and in 20 (60%) of the controls. Demodex folliculorum was detected in 34 of 37 patients (mean 15.7/cm2; total 535) and D. brevis (mean 0.6/cm2; 20 total) in six patients. Demodex folliculorum was detected in 20 of 35 healthy controls (mean 2.7/cm2; total 56) and D. brevis (mean 0.5/cm2; total 1) in one of the 35 healthy controls. When patients and controls were compared in terms of Demodex prevalence and density, the differences were statistically significant. In conclusion, Demodex mites are more prevalent in patients with seborrheic dermatitis in Erzincan Province of Turkey. This condition may be related to the amount of sebum in patients with seborrheic dermatitis, however, this issue should be supported by further studies in which sebum levels are measured and ilarger number of patients are involved.
Destekleyen Kurum
Scientific Research Projects Coordinator of Erzincan Binali Yildirim University
Proje Numarası
TSA-2017-441
Teşekkür
We would like to thank the Scientific Research Projects Coordinator of Erzincan Binali Yıldırım University, the Clinical Research Ethics Committee of Erzincan Binali Yıldırım University and all the volunteers who participated in the study for supporting this study.
Kaynakça
- Akilov, O.E. and Mumcuoglu, K.Y. 2003. Association between human demodicosis and HLA class-I. Clinical and Experimentel Dermatology, 28 (1): 70-73.
doi: 10.1046/j.1365-2230.2003.01173.x
- Akilov, O.E. and Mumcuoglu, K.Y. 2004. Immune response in demodicosis. Journal of European Academy of Dermatology and Venereology, 18 (4): 440-444.
doi: 10.1111/j.1468-3083.2004.00964.x
- Aksoy, M., Özkorumak, E., Bahadır, S., Yaylı, S. and Aksu-Arıca, D. 2012. Quality of life, anxiety and depression levels in patients with seborrheic dermatitis. Turkderm-Archives of the Turkish Dermatology and Venerology, 46 (1): 39-43.
doi: 10.4274/turkderm.83792
- Aktaş Karabay, E. and Aksu Çerman, A. 2020. Demodex folliculorum infestations in common facial dermatoses: acne vulgaris, rosacea, seborrheic dermatitis. Anais Brasileiros Dermatologia, 95 (2): 187-193
doi: 10.1016/j.abd.2019.08.023
- Aytekin, S., Yaşar, Ş. and Göktay, F. 2017. Demodex infestations. Turkiye Klinikleri Journal of Dermatology-Special Topics, 10 (2): 169-174. [In Turkish]
- Basta-Juzbasic, A., Skrlin-Subic, J. and Ljubojevic, S. 2002. Demodex folliculorum in development of dermatitis rosaceiformis steroidica and rosacea-related diseases. Clinics of Dermatology, 20 (2): 135-140.
doi: 10.1016/S0738-081X(01)00244-9
- Desch, C.E. and Nutting, W.B. 1972. Demodex folliculorum (Simon) and D. brevis Akbulatova of man: redescription and reevaluation. The Journal of Parasitology, 58 (1): 169-177.
doi: 10.2307/3278267
- Desch, C.E. and Nutting, W.B. 1977. Morphology and functional anatomy of Demodex folliculorum (Simon) of man. Acarologia, 19 (3): 422-462.
- Durmaz, S., Yula, E., Aycan-Kaya, Ö., Aksoy-Gökmen, A., Kılınç, C., Atambay, M., Ekiz, O., Gözükara-Bağ, H. and Pektaş, B. 2015. Sociodemographic characteristics of patients with Demodex brevis and Demodex folliculorum infestation and its association with rosacea and Behçet’s disease. Biomedical Research, 26 (3): 549-555.
- Erdal, B. and Albayrak, H. 2022. Investigation of the prevalence of Demodex spp. in dermatological diseases. Turkish Journal of Parasitology, 46 (1): 54-59. [In Turkish]
doi: 10.4274/tpd.galenos.2021.93685
- Forton, F.M.N. 2012. Papulopustular rosacea, skin immunity and Demodex: pityriasis folliculorum as a missing link. Journal of European Academy of Dermatology and Venereology, 26 (1): 19-28.
doi: 10.1111/j.1468-3083.2011.04310.x
- Forton, F.M.N., Germaux, M.A., Thibaut, S.C., Stene, J.A., Brasseur, T.V., Mathys, C.L., Tytgat, M.D. and Laporte, M.F. 2015. Demodicosis: descriptive classification and status of rosacea, in response to prior classification proposed. Journal of European Academy of Dermatology and Venereology, 29 (4): 829-832.
doi: 10.1111/jdv.12926
- Güleç, U. 2014. Role of Demodex folliculorum in the aetiology of seborrheic dermatitis. PhD Dissertation, Kocaeli University, Faculty of Medicine, Department of Dermatology and Venereal Diseases, 67 pp. [In Turkish]
- İnalöz, H.S. and Kırtak, N. 2002. The pathogenesis and treatment of seborrhoeic dermatitis. Turkiye Klinikleri Journal of Medical Science, 22: 239-244.
- Karakurt, Y. and Zeytun, E. 2018. Evaluation of the efficacy of tea tree oil on the density of Demodex mites (Acari: Demodicidae) and ocular symptoms in patients with demodectic blepharitis. Journal of Parasitology, 104 (5): 473-478.
doi: 10.1645/18-46
- Karıncaoğlu, Y., Tepe, B., Kalayci, B., Atambay, M. and Seyhan, M. 2009. Is Demodex folliculorum an aetiological factor in seborrhoeic dermatitis? Clinical and Experimental Dermatology, 34: e516–e520.
doi:10.1111/j.1365-2230.2009.03343.x
- Mumcuoglu, K.Y. and Akilov, O.E. 2005. The role of HLA A2 and Cw2 in the pathogenesis of human demodicosis. Dermatology, 210: 109-114.
doi: 10.1159/000082565
- Okyay, P., Ertabaklar, H., Savk, E. and Ertuğ, S. 2006. Prevalence of Demodex folliculorum in young adults: relation with sociodemographic/hygienic factors and acne vulgaris. Journal of European Academy of Dermatology and Venereology, 20 (4): 474-476.
doi: 10.1111/j.1468-3083.2006.01470.x
- Özdemir, M.H., Aksoy, U., Sönmez, E., Aksu, Ç., Yorulmaz, C. and Hilal, A. 2005. Prevalence of Demodex in health personnel working in the autopsy room. The American Journal of Forensic Medicine and Pathology, 26 (1): 18-23.
doi: 10.1097/01.paf.0000154368.04177.fc
- Rufli, T. and Mumcuoglu, Y. 1981. The hair follicle mites D. folliculorum and D. brevis: biology and medical importance. Dermatology, 162: 1-11.
doi: 10.1159/000250228
- Sarı, Y., Zeytun, E., Doğan, S. and Karakurt, Y. 2019. The prevalence and intensity of Demodex folliculorum and D. brevis (Acari: Demodicidae) in patients with ocular dandruff. Acarological Stuies, 1 (1): 23-43. [In Turkish]
- Tehrani, S., Tizmaghz, A. and Shabestanipour, G. 2014. The Demodex mites and their relation with seborrheic and atopic dermatitis. Asian Pacific Journal of Tropical Medicine, 7: 82-84.
doi: 10.1016/S1995-7645(14)60208-X
- Tilki, E., Zeytun, E. and Doğan, S. 2017. Prevalence and density of Demodex folliculorum and Demodex brevis (Acari: Demodicidae) in Erzincan province. Turkish Journal of Parasitology, 41 (2): 80-86. [In Turkish]
doi: 10.5152/tpd.2017.5156
- Yılmaz, H. and Akkaş, Ö. 2020. Investigation of Demodex spp. prevalence in medical laboratory students. Medicine Science, 9 (4): 844-847.
doi: 10.5455/medscience.2020.04.068
- Zeytun, E. 2017. Demodex (Acari: Demodicidae) infestation in the elderly and its relationship with the skin parameters such as moisture, pH, and temperature: a cross-sectional study. Turkish Journal of Geriatrics, 20 (2): 142-150.
- Zeytun, E. and Ölmez, H. 2017. Demodex (Acari: Demodicidae) infestation in patients with KOAH, and the association with immunosuppression. Erzincan University Journal of Science and Technology, 10 (2): 220-231. [In Turkish]
doi: 10.18185/erzifbed.335850
- Zeytun, E., Tilki, E., Doğan, S. and Mumcuoğlu, K.Y. 2017. The effect of skin moisture, pH, and temperature on the density of Demodex folliculorum and Demodex brevis (Acari: Demodicidae) in students and staff of the Erzincan University, Turkey. International Journal of Dermatology, 56 (7): 762-766.
doi: 10.1111/ijd.13600
- Zeytun, E. and Karakurt, Y. 2019. Prevalence and load of Demodex folliculorum and Demodex brevis (Acari: Demodicidae) in patients with chronic blepharitis in the Province of Erzincan, Turkey. Journal of Medical Entomology, 56 (1): 2-9.
doi: 10.1093/jme/tjy143
- Zeytun, E and Yazıcı, M. 2019. Incidence and density of Demodex folliculorum and Demodex brevis (Acari: Demodicidae) in patients with acne in the province of Erzincan, Turkey. International Journal of Acarology, 45 (3): 108-112.
doi: 10.1080/01647954.2018.1564790
- Zhao, Y.E., Guo, N., Xun, M., Xu, J.R., Wang, M. and Wang, D.L. 2011. Sociodemographic characteristics and risk factor analysis of Demodex infestation (Acari: Demodicidae). Journal of Zhejiang University Science B, 12 (12): 998-1007.
doi: 10.1631/jzus.B1100079
Yıl 2022,
, 54 - 60, 28.07.2022
Erhan Zeytun
,
Mustafa Yazıcı
Proje Numarası
TSA-2017-441
Kaynakça
- Akilov, O.E. and Mumcuoglu, K.Y. 2003. Association between human demodicosis and HLA class-I. Clinical and Experimentel Dermatology, 28 (1): 70-73.
doi: 10.1046/j.1365-2230.2003.01173.x
- Akilov, O.E. and Mumcuoglu, K.Y. 2004. Immune response in demodicosis. Journal of European Academy of Dermatology and Venereology, 18 (4): 440-444.
doi: 10.1111/j.1468-3083.2004.00964.x
- Aksoy, M., Özkorumak, E., Bahadır, S., Yaylı, S. and Aksu-Arıca, D. 2012. Quality of life, anxiety and depression levels in patients with seborrheic dermatitis. Turkderm-Archives of the Turkish Dermatology and Venerology, 46 (1): 39-43.
doi: 10.4274/turkderm.83792
- Aktaş Karabay, E. and Aksu Çerman, A. 2020. Demodex folliculorum infestations in common facial dermatoses: acne vulgaris, rosacea, seborrheic dermatitis. Anais Brasileiros Dermatologia, 95 (2): 187-193
doi: 10.1016/j.abd.2019.08.023
- Aytekin, S., Yaşar, Ş. and Göktay, F. 2017. Demodex infestations. Turkiye Klinikleri Journal of Dermatology-Special Topics, 10 (2): 169-174. [In Turkish]
- Basta-Juzbasic, A., Skrlin-Subic, J. and Ljubojevic, S. 2002. Demodex folliculorum in development of dermatitis rosaceiformis steroidica and rosacea-related diseases. Clinics of Dermatology, 20 (2): 135-140.
doi: 10.1016/S0738-081X(01)00244-9
- Desch, C.E. and Nutting, W.B. 1972. Demodex folliculorum (Simon) and D. brevis Akbulatova of man: redescription and reevaluation. The Journal of Parasitology, 58 (1): 169-177.
doi: 10.2307/3278267
- Desch, C.E. and Nutting, W.B. 1977. Morphology and functional anatomy of Demodex folliculorum (Simon) of man. Acarologia, 19 (3): 422-462.
- Durmaz, S., Yula, E., Aycan-Kaya, Ö., Aksoy-Gökmen, A., Kılınç, C., Atambay, M., Ekiz, O., Gözükara-Bağ, H. and Pektaş, B. 2015. Sociodemographic characteristics of patients with Demodex brevis and Demodex folliculorum infestation and its association with rosacea and Behçet’s disease. Biomedical Research, 26 (3): 549-555.
- Erdal, B. and Albayrak, H. 2022. Investigation of the prevalence of Demodex spp. in dermatological diseases. Turkish Journal of Parasitology, 46 (1): 54-59. [In Turkish]
doi: 10.4274/tpd.galenos.2021.93685
- Forton, F.M.N. 2012. Papulopustular rosacea, skin immunity and Demodex: pityriasis folliculorum as a missing link. Journal of European Academy of Dermatology and Venereology, 26 (1): 19-28.
doi: 10.1111/j.1468-3083.2011.04310.x
- Forton, F.M.N., Germaux, M.A., Thibaut, S.C., Stene, J.A., Brasseur, T.V., Mathys, C.L., Tytgat, M.D. and Laporte, M.F. 2015. Demodicosis: descriptive classification and status of rosacea, in response to prior classification proposed. Journal of European Academy of Dermatology and Venereology, 29 (4): 829-832.
doi: 10.1111/jdv.12926
- Güleç, U. 2014. Role of Demodex folliculorum in the aetiology of seborrheic dermatitis. PhD Dissertation, Kocaeli University, Faculty of Medicine, Department of Dermatology and Venereal Diseases, 67 pp. [In Turkish]
- İnalöz, H.S. and Kırtak, N. 2002. The pathogenesis and treatment of seborrhoeic dermatitis. Turkiye Klinikleri Journal of Medical Science, 22: 239-244.
- Karakurt, Y. and Zeytun, E. 2018. Evaluation of the efficacy of tea tree oil on the density of Demodex mites (Acari: Demodicidae) and ocular symptoms in patients with demodectic blepharitis. Journal of Parasitology, 104 (5): 473-478.
doi: 10.1645/18-46
- Karıncaoğlu, Y., Tepe, B., Kalayci, B., Atambay, M. and Seyhan, M. 2009. Is Demodex folliculorum an aetiological factor in seborrhoeic dermatitis? Clinical and Experimental Dermatology, 34: e516–e520.
doi:10.1111/j.1365-2230.2009.03343.x
- Mumcuoglu, K.Y. and Akilov, O.E. 2005. The role of HLA A2 and Cw2 in the pathogenesis of human demodicosis. Dermatology, 210: 109-114.
doi: 10.1159/000082565
- Okyay, P., Ertabaklar, H., Savk, E. and Ertuğ, S. 2006. Prevalence of Demodex folliculorum in young adults: relation with sociodemographic/hygienic factors and acne vulgaris. Journal of European Academy of Dermatology and Venereology, 20 (4): 474-476.
doi: 10.1111/j.1468-3083.2006.01470.x
- Özdemir, M.H., Aksoy, U., Sönmez, E., Aksu, Ç., Yorulmaz, C. and Hilal, A. 2005. Prevalence of Demodex in health personnel working in the autopsy room. The American Journal of Forensic Medicine and Pathology, 26 (1): 18-23.
doi: 10.1097/01.paf.0000154368.04177.fc
- Rufli, T. and Mumcuoglu, Y. 1981. The hair follicle mites D. folliculorum and D. brevis: biology and medical importance. Dermatology, 162: 1-11.
doi: 10.1159/000250228
- Sarı, Y., Zeytun, E., Doğan, S. and Karakurt, Y. 2019. The prevalence and intensity of Demodex folliculorum and D. brevis (Acari: Demodicidae) in patients with ocular dandruff. Acarological Stuies, 1 (1): 23-43. [In Turkish]
- Tehrani, S., Tizmaghz, A. and Shabestanipour, G. 2014. The Demodex mites and their relation with seborrheic and atopic dermatitis. Asian Pacific Journal of Tropical Medicine, 7: 82-84.
doi: 10.1016/S1995-7645(14)60208-X
- Tilki, E., Zeytun, E. and Doğan, S. 2017. Prevalence and density of Demodex folliculorum and Demodex brevis (Acari: Demodicidae) in Erzincan province. Turkish Journal of Parasitology, 41 (2): 80-86. [In Turkish]
doi: 10.5152/tpd.2017.5156
- Yılmaz, H. and Akkaş, Ö. 2020. Investigation of Demodex spp. prevalence in medical laboratory students. Medicine Science, 9 (4): 844-847.
doi: 10.5455/medscience.2020.04.068
- Zeytun, E. 2017. Demodex (Acari: Demodicidae) infestation in the elderly and its relationship with the skin parameters such as moisture, pH, and temperature: a cross-sectional study. Turkish Journal of Geriatrics, 20 (2): 142-150.
- Zeytun, E. and Ölmez, H. 2017. Demodex (Acari: Demodicidae) infestation in patients with KOAH, and the association with immunosuppression. Erzincan University Journal of Science and Technology, 10 (2): 220-231. [In Turkish]
doi: 10.18185/erzifbed.335850
- Zeytun, E., Tilki, E., Doğan, S. and Mumcuoğlu, K.Y. 2017. The effect of skin moisture, pH, and temperature on the density of Demodex folliculorum and Demodex brevis (Acari: Demodicidae) in students and staff of the Erzincan University, Turkey. International Journal of Dermatology, 56 (7): 762-766.
doi: 10.1111/ijd.13600
- Zeytun, E. and Karakurt, Y. 2019. Prevalence and load of Demodex folliculorum and Demodex brevis (Acari: Demodicidae) in patients with chronic blepharitis in the Province of Erzincan, Turkey. Journal of Medical Entomology, 56 (1): 2-9.
doi: 10.1093/jme/tjy143
- Zeytun, E and Yazıcı, M. 2019. Incidence and density of Demodex folliculorum and Demodex brevis (Acari: Demodicidae) in patients with acne in the province of Erzincan, Turkey. International Journal of Acarology, 45 (3): 108-112.
doi: 10.1080/01647954.2018.1564790
- Zhao, Y.E., Guo, N., Xun, M., Xu, J.R., Wang, M. and Wang, D.L. 2011. Sociodemographic characteristics and risk factor analysis of Demodex infestation (Acari: Demodicidae). Journal of Zhejiang University Science B, 12 (12): 998-1007.
doi: 10.1631/jzus.B1100079