Relationship between plasma atherogenic index and coronary slow flow phenomenon

Yıl 2023, Cilt: 2 Sayı: 2, 76 - 83, 28.03.2023

Birsen Doğanay

https://doi.org/10.5505/achmedj.2023.92400

Öz

Introduction: Epidemiological studies indicated that patients suffering from coronary slow flow phenomenon (CSFP) are predisposed to dyslipidemia. However, there are limited studies evaluating
the relationship between atherogenic index of plasma (AIP), which is a novel indicator of atherogenic dyslipidemia, and CSFP. This
study aimed to investigate the prognostic role of the AIP in predicting CSFP among patients with undergoing coronary angiography.
Methods: This retrospective study included 110 patients with CSFP diagnosed by methods of Thrombolysis in Myocardial Infarction (TIMI)-frame count (TFC) and 110 controls with normal coronary flow (NCF). AIP
obtained as the base 10 logarithm of the ratio of triglycerides to HDL.
Results: Mean AIP level was higher in the CSFP group than NCF
group (0.6 ± 0.2 vs. 0.4 ± 0.2, p < 0.001). Multivariable regression analysis showed that AIP level (OR = 15.33, 95% CI = 4.11-
57.18, p < 0.001), as well as neutrophil and platelets levels, were
independent predictor of CSFP. The threshold value of the AIP
in predicting CSFP was >0.7 with 64.5% sensitivity and 69.8%
specificity (Area under the curve [AUC] = 0.714, p < 0.001).
Conclusion: API was higher in CSFP patients and was determined as an independent predictor of CSFP. Prior to planned diagnostic coronary angiography, API exhibits significant diagnostic performance in predicting CSFP.

Anahtar Kelimeler

Atherogenic index of plasma, Biomarkers, Coronary slow flow, Frame count