Abnormal Fetal Cardiac Function and Umbilical Cord Blood Brain Natriuretic Peptide Levels in Intrahepatic Cholestasis of Pregnancy

Yıl 2023, Cilt: 2 Sayı: 3, 97 - 103, 03.07.2023

Ramazan Denizli

https://doi.org/10.5505/achmedj.2023.00719

Öz

Introduction:We aim to evaluate fetal cardiac function and umbilical cord
blood pro-BNP (pro-brain natriuretic peptide) levels in ICP (intrahepatic
cholestasis of pregnancy).
Methods:The study included 41 ICP cases and 41 controls. All participants were
evaluated after 34 weeks of gestation. The pro-BNP levels in umbilical cord blood were assayed, and perinatal outcomes were compared between the groups.
Results: In the ICP group SBA (serum bile acid) and pro-BNP levels were
higher than the control group (p<0.001 and p=0.001). The left MPI (myocardial performance index) of ICP group was higher among the control
group (p=0.043). A positive correlation was evaluated between the proBNP levels and MPI values (p<0.001).
Conclusion: Both the high MPI values obtained via ultrasonography and the high pro-BNP levels detected in umbilical cord blood may be attributable to the adverse fetal cardiac effects of ICP.

Anahtar Kelimeler

Fetal cardiac function, Fetal Doppler ultrasound, Intrahepatic cholestasis of pregnancy, Pro-brain natriuretic peptide, Serum bile acid.