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HALP score can predict the no-reflow phenomenon and in-hospital mortality after saphenous vein graft intervention

Yıl 2025, Cilt: 7 Sayı: 1, 1 - 7, 10.01.2025
https://doi.org/10.38053/acmj.1549660

Öz

Aims: The no-reflow phenomenon (NRP) is one of the most frequently observed complications in saphenous vein graft (SVG) interventions. The aim of this study was to investigate the effect of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score on the development of NRP in patients with acute coronary syndrome (ACS) undergoing percutaneous SVG intervention.
Methods: This retrospective study included 263 patients who applied to our center with the diagnosis of ACS and underwent saphenous vein grafting procedure. The patients were divided into two groups according to whether no-reflow developed or not, and the HALP scores of the groups were compared. In addition, in-hospital mortality was compared between the study groups according to their HALP score values. The predictive ability of the HALP score for no-reflow was evaluated using a receiver operating characteristic curve.
Results: NRP developed in 103 (39.2%) of the patients included in the study patients. HALP score value was found to be significantly lower in the no-reflow group (45.3±20 vs 53.8±18, p:0.001). In the receiver operating characteristic (ROC) analysis, the cutoff value for the HALP score was calculated as 46.5. After multivariable adjustment, the HALP score <46.5 was an independent predictor of no-reflow (OR=4.95, 95% CI:2.48-9.89; p<0.001). Additionally, HALP score was found to be an indicator for in-hospital mortality (0.036).
Conclusion: The HALP score proves to be a valuable predictive tool for NRP and in-hospital mortality in patients with presenting to the emergency department with ACS and undergoing SVG intervention.

Etik Beyan

2024-TBEK 2024/09-02

Destekleyen Kurum

SBÜ BURSA YÜKSEK İHTİSAS EAH TIP BİLİMLERİ ETİK KURULU

Kaynakça

  • de Vries MR, Quax PHA. Inflammation in Vein Graft Disease. Front Cardiovasc Med. 2018;5:3. doi:10.3389/fcvm.2018.00003
  • Neumann FJ, Sousa-Uva M, Ahlsson A, et al. 2018 ESC/EACTS Guidelines on myocardial revascularization [published correction appears in Eur Heart J. 2019;40(37):3096. doi:10.1093/eurheartj/ehz507]. Eur Heart J. 2019;40(2):87-165. doi:10.1093/eurheartj/ehy394
  • Harskamp RE, Lopes RD, Baisden CE, de Winter RJ, Alexander JH. Saphenous vein graft failure after coronary artery bypass surgery: pathophysiology, management, and future directions. Ann Surg. 2013; 257(5):824-833. doi:10.1097/SLA.0b013e318288c38d
  • Lee MS, Park SJ, Kandzari DE, et al. Saphenous vein graft intervention. JACC Cardiovasc Interv. 2011;4(8):831-843. doi:10.1016/j.jcin.2011.05.014
  • Soverow J, Lee MS. Saphenous vein graft intervention: status report 2014. J Invasive Cardiol. 2014;26(12):659-667.
  • Salinas P, Jimenez-Valero S, Moreno R, et al. Update in pharmacological management of coronary no-reflow phenomenon. Cardiovasc Hematol Agents Med Chem. 2012;10(3):256-264. doi:10.2174/187152512802651024
  • Gürbak İ, Panç C, Şahin AA, et al. CHA2DS2-VASc score as a predictor of no-reflow phenomenon after saphenous vein graft percutaneous coronary intervention in patients with non-ST-segment elevation acute coronary syndromes. Kardiol Pol. 2020;78(11):1129-1136. doi:10.33963/KP.15603
  • De Luca G, Suryapranata H, Marino P. Reperfusion strategies in acute ST-elevation myocardial infarction: an overview of current status. Prog Cardiovasc Dis. 2008;50(5):352-382. doi:10.1016/j.pcad.2007.11.004
  • Gupta S, Gupta MM. No reflow phenomenon in percutaneous coronary interventions in ST-segment elevation myocardial infarction. Indian Heart J. 2016;68(4):539-551. doi:10.1016/j.ihj.2016.04.006
  • Montone RA, Camilli M, Del Buono MG, et al. “No-reflow”: update su diagnosi, fisiopatologia e strategie terapeutiche [No-reflow: update on diagnosis, pathophysiology and therapeutic strategies]. G Ital Cardiol (Rome). 2020;21(6 Suppl 1):4S-14S. doi:10.1714/3373.33487
  • Antar R, Farag C, Xu V, Drouaud A, Gordon O, Whalen MJ. Evaluating the baseline hemoglobin, albumin, lymphocyte, and platelet (HALP) score in the United States adult population and comorbidities: an analysis of the NHANES. Front Nutr. 2023;10:1206958. doi:10.3389/fnut.2023.1206958
  • Akbar KMA, Dharma S, Andriantoro H, Sukmawan R, Mangkuanom AS, Rejeki VG. Relationship between hemoglobin concentration at admission with the incidence of no-reflow phenomenon and in-hospital mortality in acute myocardial infarction with elevation of st segments in patients who underwent primary percutaneous coronary intervention. Int J Angiol. 2022;32(2):106-112. doi:10.1055/s-0042-1742308
  • Zhao Y, Yang J, Ji Y, et al. Usefulness of fibrinogen-to-albumin ratio to predict no-reflow and short-term prognosis in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Heart Vessels. 2019;34(10):1600-1607. doi:10.1007/s00380-019-01399-w
  • Karakayali M, Omar T, Artac I, et al. The prognostic value of HALP score in predicting in-hospital mortality in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Coron Artery Dis. 2023;34(7):483-488. doi:10.1097/MCA. 0000000000001271
  • Kirma C, Izgi A, Dundar C, et al. Clinical and procedural predictors of no-reflow phenomenon after primary percutaneous coronary interventions: experience at a single center. Circ J. 2008;72(5):716-721. doi:10.1253/circj.72.716
  • Sianos G, Papafaklis MI, Serruys PW. Angiographic thrombus burden classification in patients with ST-segment elevation myocardial infarction treated with percutaneous coronary intervention. J Invasive Cardiol. 2010;22(10 Suppl B):6B-14B.
  • Thygesen K, Alpert JS, Jaffe AS, et al. Fourth universal definition of myocardial infarction (2018). Eur Heart J. 2019;40(3):237-269. doi:10. 1093/eurheartj/ehy462
  • American Diabetes Association. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2018. Diabetes Care. 2018;41(Suppl 1):S13-S27. doi:10.2337/dc18-S002
  • Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of diet in renal disease study group. Ann Intern Med. 1999;130(6):461-470. doi:10. 7326/0003-4819-130-6-199903160-00002
  • Xu H, Zheng X, Ai J, Yang L. Hemoglobin, albumin, lymphocyte, and platelet (HALP) score and cancer prognosis: a systematic review and meta-analysis of 13,110 patients. Int Immunopharmacol. 2023;114: 109496. doi:10.1016/j.intimp.2022.109496
  • Xu SS, Li S, Xu HX, et al. Haemoglobin, albumin, lymphocyte and platelet predicts postoperative survival in pancreatic cancer. World J Gastroenterol. 2020;26(8):828-838. doi:10.3748/wjg.v26.i8.828
  • Tian M, Li Y, Wang X, et al. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score is associated with poor outcome of acute ischemic stroke. Front Neurol. 2021;11:610318. doi:10.3389/fneur.2020.610318
  • Toprak K, Toprak İH, Acar O, Ermiş MF. The predictive value of the HALP score for no-reflow phenomenon and short-term mortality in patients with ST-elevation myocardial infarction. Postgrad Med. 2024; 136(2):169-179. doi:10.1080/00325481.2024.2319567
  • Kaur G, Baghdasaryan P, Natarajan B, et al. Pathophysiology, diagnosis, and management of coronary no-reflow phenomenon. Int J Angiol. 2021; 30(1):15-21. doi:10.1055/s-0041-1725979
  • Roche M, Rondeau P, Singh NR, Tarnus E, Bourdon E. The antioxidant properties of serum albumin. FEBS Lett. 2008;582(13):1783-1787. doi: 10.1016/j.febslet.2008.04.057
  • Bouleti C, Mewton N, Germain S. The no-reflow phenomenon: State of the art. Arch Cardiovasc Dis. 2015;108(12):661-674. doi:10.1016/j.acvd. 2015.09.006
  • Rezkalla SH, Dharmashankar KC, Abdalrahman IB, Kloner RA. No-reflow phenomenon following percutaneous coronary intervention for acute myocardial infarction: incidence, outcome, and effect of pharmacologic therapy. J Interv Cardiol. 2010;23(5):429-436. doi:10. 1111/j.1540-8183.2010.00561.x
  • Özen Y, Bilal Özbay M. Assessment of systemic immune-inflammation index as an independent surrogate biomarker of no-reflow phenomenon in acute coronary syndrome patients with coronary artery bypass grafting undergoing percutaneous coronary intervention of saphenous vein graft. Eur Rev Med Pharmacol Sci. 2023;27(6):2394-2403. doi:10. 26355/eurrev_202303_31774
  • Hashemi-Jazi M, Hosseini SM, Gholamrezaei A. Factors associated with the no-reflow phenomenon following percutaneous intervention of saphenous vein coronary bypass grafts. ARYA Atheroscler. 2017;13(5): 221-229.
  • Leborgne L, Cheneau E, Pichard A, et al. Effect of direct stenting on clinical outcome in patients treated with percutaneous coronary intervention on saphenous vein graft. Am Heart J. 2003;146(3):501-506. doi:10.1016/S0002-8703(03)00309-0
Yıl 2025, Cilt: 7 Sayı: 1, 1 - 7, 10.01.2025
https://doi.org/10.38053/acmj.1549660

Öz

Kaynakça

  • de Vries MR, Quax PHA. Inflammation in Vein Graft Disease. Front Cardiovasc Med. 2018;5:3. doi:10.3389/fcvm.2018.00003
  • Neumann FJ, Sousa-Uva M, Ahlsson A, et al. 2018 ESC/EACTS Guidelines on myocardial revascularization [published correction appears in Eur Heart J. 2019;40(37):3096. doi:10.1093/eurheartj/ehz507]. Eur Heart J. 2019;40(2):87-165. doi:10.1093/eurheartj/ehy394
  • Harskamp RE, Lopes RD, Baisden CE, de Winter RJ, Alexander JH. Saphenous vein graft failure after coronary artery bypass surgery: pathophysiology, management, and future directions. Ann Surg. 2013; 257(5):824-833. doi:10.1097/SLA.0b013e318288c38d
  • Lee MS, Park SJ, Kandzari DE, et al. Saphenous vein graft intervention. JACC Cardiovasc Interv. 2011;4(8):831-843. doi:10.1016/j.jcin.2011.05.014
  • Soverow J, Lee MS. Saphenous vein graft intervention: status report 2014. J Invasive Cardiol. 2014;26(12):659-667.
  • Salinas P, Jimenez-Valero S, Moreno R, et al. Update in pharmacological management of coronary no-reflow phenomenon. Cardiovasc Hematol Agents Med Chem. 2012;10(3):256-264. doi:10.2174/187152512802651024
  • Gürbak İ, Panç C, Şahin AA, et al. CHA2DS2-VASc score as a predictor of no-reflow phenomenon after saphenous vein graft percutaneous coronary intervention in patients with non-ST-segment elevation acute coronary syndromes. Kardiol Pol. 2020;78(11):1129-1136. doi:10.33963/KP.15603
  • De Luca G, Suryapranata H, Marino P. Reperfusion strategies in acute ST-elevation myocardial infarction: an overview of current status. Prog Cardiovasc Dis. 2008;50(5):352-382. doi:10.1016/j.pcad.2007.11.004
  • Gupta S, Gupta MM. No reflow phenomenon in percutaneous coronary interventions in ST-segment elevation myocardial infarction. Indian Heart J. 2016;68(4):539-551. doi:10.1016/j.ihj.2016.04.006
  • Montone RA, Camilli M, Del Buono MG, et al. “No-reflow”: update su diagnosi, fisiopatologia e strategie terapeutiche [No-reflow: update on diagnosis, pathophysiology and therapeutic strategies]. G Ital Cardiol (Rome). 2020;21(6 Suppl 1):4S-14S. doi:10.1714/3373.33487
  • Antar R, Farag C, Xu V, Drouaud A, Gordon O, Whalen MJ. Evaluating the baseline hemoglobin, albumin, lymphocyte, and platelet (HALP) score in the United States adult population and comorbidities: an analysis of the NHANES. Front Nutr. 2023;10:1206958. doi:10.3389/fnut.2023.1206958
  • Akbar KMA, Dharma S, Andriantoro H, Sukmawan R, Mangkuanom AS, Rejeki VG. Relationship between hemoglobin concentration at admission with the incidence of no-reflow phenomenon and in-hospital mortality in acute myocardial infarction with elevation of st segments in patients who underwent primary percutaneous coronary intervention. Int J Angiol. 2022;32(2):106-112. doi:10.1055/s-0042-1742308
  • Zhao Y, Yang J, Ji Y, et al. Usefulness of fibrinogen-to-albumin ratio to predict no-reflow and short-term prognosis in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Heart Vessels. 2019;34(10):1600-1607. doi:10.1007/s00380-019-01399-w
  • Karakayali M, Omar T, Artac I, et al. The prognostic value of HALP score in predicting in-hospital mortality in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Coron Artery Dis. 2023;34(7):483-488. doi:10.1097/MCA. 0000000000001271
  • Kirma C, Izgi A, Dundar C, et al. Clinical and procedural predictors of no-reflow phenomenon after primary percutaneous coronary interventions: experience at a single center. Circ J. 2008;72(5):716-721. doi:10.1253/circj.72.716
  • Sianos G, Papafaklis MI, Serruys PW. Angiographic thrombus burden classification in patients with ST-segment elevation myocardial infarction treated with percutaneous coronary intervention. J Invasive Cardiol. 2010;22(10 Suppl B):6B-14B.
  • Thygesen K, Alpert JS, Jaffe AS, et al. Fourth universal definition of myocardial infarction (2018). Eur Heart J. 2019;40(3):237-269. doi:10. 1093/eurheartj/ehy462
  • American Diabetes Association. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2018. Diabetes Care. 2018;41(Suppl 1):S13-S27. doi:10.2337/dc18-S002
  • Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of diet in renal disease study group. Ann Intern Med. 1999;130(6):461-470. doi:10. 7326/0003-4819-130-6-199903160-00002
  • Xu H, Zheng X, Ai J, Yang L. Hemoglobin, albumin, lymphocyte, and platelet (HALP) score and cancer prognosis: a systematic review and meta-analysis of 13,110 patients. Int Immunopharmacol. 2023;114: 109496. doi:10.1016/j.intimp.2022.109496
  • Xu SS, Li S, Xu HX, et al. Haemoglobin, albumin, lymphocyte and platelet predicts postoperative survival in pancreatic cancer. World J Gastroenterol. 2020;26(8):828-838. doi:10.3748/wjg.v26.i8.828
  • Tian M, Li Y, Wang X, et al. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score is associated with poor outcome of acute ischemic stroke. Front Neurol. 2021;11:610318. doi:10.3389/fneur.2020.610318
  • Toprak K, Toprak İH, Acar O, Ermiş MF. The predictive value of the HALP score for no-reflow phenomenon and short-term mortality in patients with ST-elevation myocardial infarction. Postgrad Med. 2024; 136(2):169-179. doi:10.1080/00325481.2024.2319567
  • Kaur G, Baghdasaryan P, Natarajan B, et al. Pathophysiology, diagnosis, and management of coronary no-reflow phenomenon. Int J Angiol. 2021; 30(1):15-21. doi:10.1055/s-0041-1725979
  • Roche M, Rondeau P, Singh NR, Tarnus E, Bourdon E. The antioxidant properties of serum albumin. FEBS Lett. 2008;582(13):1783-1787. doi: 10.1016/j.febslet.2008.04.057
  • Bouleti C, Mewton N, Germain S. The no-reflow phenomenon: State of the art. Arch Cardiovasc Dis. 2015;108(12):661-674. doi:10.1016/j.acvd. 2015.09.006
  • Rezkalla SH, Dharmashankar KC, Abdalrahman IB, Kloner RA. No-reflow phenomenon following percutaneous coronary intervention for acute myocardial infarction: incidence, outcome, and effect of pharmacologic therapy. J Interv Cardiol. 2010;23(5):429-436. doi:10. 1111/j.1540-8183.2010.00561.x
  • Özen Y, Bilal Özbay M. Assessment of systemic immune-inflammation index as an independent surrogate biomarker of no-reflow phenomenon in acute coronary syndrome patients with coronary artery bypass grafting undergoing percutaneous coronary intervention of saphenous vein graft. Eur Rev Med Pharmacol Sci. 2023;27(6):2394-2403. doi:10. 26355/eurrev_202303_31774
  • Hashemi-Jazi M, Hosseini SM, Gholamrezaei A. Factors associated with the no-reflow phenomenon following percutaneous intervention of saphenous vein coronary bypass grafts. ARYA Atheroscler. 2017;13(5): 221-229.
  • Leborgne L, Cheneau E, Pichard A, et al. Effect of direct stenting on clinical outcome in patients treated with percutaneous coronary intervention on saphenous vein graft. Am Heart J. 2003;146(3):501-506. doi:10.1016/S0002-8703(03)00309-0
Toplam 30 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Kardiyoloji
Bölüm Research Articles
Yazarlar

Ömer Furkan Demir 0000-0002-0230-8442

Barış Şensoy 0000-0003-0066-9946

Yayımlanma Tarihi 10 Ocak 2025
Gönderilme Tarihi 13 Eylül 2024
Kabul Tarihi 16 Kasım 2024
Yayımlandığı Sayı Yıl 2025 Cilt: 7 Sayı: 1

Kaynak Göster

AMA Demir ÖF, Şensoy B. HALP score can predict the no-reflow phenomenon and in-hospital mortality after saphenous vein graft intervention. Anatolian Curr Med J / ACMJ / acmj. Ocak 2025;7(1):1-7. doi:10.38053/acmj.1549660

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