acta med nicomedia Acta Medica Nicomedia 2717-8994 2717-8994 Kocaeli Üniversitesi 10.53446/actamednicomedia.1333600 Clinical Sciences (Other) Klinik Tıp Bilimleri (Diğer) Investigation of the Relationship Between C-Reactive Protein and Pentraxin-3 Levels in Systemic Lupus Erythematosus Disease Sistemik Lupus Eritematozus Hastalığında C-Reaktif Protein ve Pentraksin-3 Düzeyleri Arasındaki İlişkinin Araştırılması https://orcid.org/0000-0003-4210-4994 Aslantaş Şükran Dr., Kütahya Simav Doç.Dr. İsmail Karakuyu Devlet Hastanesi https://orcid.org/0000-0002-8613-5373 Oruçoğlu Nurdan MERSİN ÜNİVERSİTESİ, TIP FAKÜLTESİ https://orcid.org/0000-0002-4405-521X Türkegün Şengül Merve ALANYA ALAADDIN KEYKUBAT UNIVERSITY https://orcid.org/0000-0002-7498-604X Balcı Senay MERSIN UNIVERSITY https://orcid.org/0000-0002-0997-0260 Tamer Lülüfer MERSİN ÜNİVERSİTESİ 02 29 2024 7 1 57 62 07 27 2023 01 19 2024 Copyright © 2020, Acta Medica Nicomedia 2020 Acta Medica Nicomedia

Aim: Systemic lupus erythematosus is an autoimmune disease with an unpredictable course that includes polyclonal autoimmunity against multiple autoantigens and has a wide spectrum of clinical manifestations. In autoimmune diseases, levels of pentraxin-3, a member of the long pentraxin family, have been found to be increased in the circulation. Pentraxin-3 is produced by innate and resident immune cells in peripheral tissues in response to inflammatory signals. In this study, it was aimed to investigate the relationship between CRP and pentraxin-3 levels in systemic lupus erythematosus, which is characterized by chronic inflammation and immune dysfunction.Method: Fifty-six patients with SLE and 55 healthy individuals who met the inclusion criteria were included in the study. CBC, ESR, ALT, creatinine and CRP were analyzed by autoanalyzer; pentraxin-3 levels were studied by ELISA from serum samples.Results: According to the control group in patients; hematological parameters, creatinine and ALT levels were lower, sediment results are higher, CRP and pentraxin-3 levels were found to be higher (respectively p= 0.003; p= 0.008). When the correlation between Pentraxin-3 and other parameters and within-group levels was evaluated, no statistically significant correlation was found.Conclusion: Systemic lupus erythematosus is a disease that has different tissue and organ involvement and accordingly causes different clinical symptoms. At the same time, the spectrum of these symptoms is quite wide. Therefore, we suggest further studies by grouping according to genetic susceptibility, tissue and organ involvement, and severity and activity of the disease associated with systemic lupus erythematosus.

Amaç: Sistemik lupus eritematozus, çoklu otoantijenlere karşı poliklonal otoimmüniteyi içeren ve çok çeşitli klinik belirti spektrumuna sahip, öngörülemeyen seyirli otoimmün bir hastalıktır. Otoimmün hastalıklarda, uzun pentraksin ailesininden olan pentraksin-3 seviyelerinin dolaşımda arttığı bulunmuştur. Pentraksin-3, diğer pentraksinlerden farklı olarak periferal dokularda yerleşik ve doğal bağışıklık hücreleri tarafından, enflamatuar sinyallere cevap olarak üretilir. Bu çalışmada, kronik enflamasyon ve immün fonksiyon bozukluğu ile karakterize olan sistemik lupus eritematozus’da, inflamatuar belirteçlerden C-reaktif protein ve pentraksin-3 düzeyleri arasındaki ilişkinin araştırılması amaçlandı. Yöntem: Çalışmaya, dahil edilme kriterlerine uyan, sistemik lupus eritematozus tanısı almış 56 hasta ve 55 sağlıklı birey dahil edildi. Tam kan sayımı, eritrosit sedimantasyon hızı, alanin transaminaz, kreatinin ve C-reaktif protein otoanalizörde çalışılırken; pentraksin-3 düzeyleri, serum örneklerinden, ELISA yöntemi ile çalışıldı. Bulgular: Çalışma verileri incelendiğinde, hasta grubunda kontrol grubuna kıyasla hematolojik eritrosit sedimantasyon hızı sonuçları daha yüksek bulundu (p

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