Calvarial Hyperostosis Syndrome in an American Pit Bull Terrier

Yıl 2018, Cilt: 44 Sayı: 1, 49 - 52, 16.01.2018

Damla Haktanır Ebru Eravcı Yalın Yalçın Devecioğlu Alper Demirutku Aydın Gürel

Öz

Calvarial hyperostosis syndrome (CHS),
which has been recently defined in juvenile dogs, is a rare, non-neoplastic,
proliferative bone disease characterized by the swelling of the skull. Until
recently, it was mostly reported in young Bullmastiffs with a sexual preference
for male dogs. The objective of this study was to describe the clinical and
pathological aspects of the condition as a contribution to literature due to
its rarity in dogs. The paper presents the first reported case of Calvarial
hyperostosis in turkey. A four-month-old female American Pit bull terrier was
presented to the veterinary physician with the complaints of painful swelling
on the head, loss of appetite, lethargy and fever. Radiograph of the skull
revealed diffuse thickening of the frontal and parietal bones and markedly
increased bone opacity, and magnetic resonance imaging (MRI) scans revealed
increased diploe thickness in all sequences. The preliminary clinical diagnosis
of calvarial hyperostosis was confirmed by histopathology which revealed the
presence of both immature woven bone and mature bone trabeculae separated by
prominent basophilic cementing lines. The lesion is self-limiting, and most
cases show spontaneous regression in few months, but in this case the patient
was monitored until one year of age and no regression was seen. 

Anahtar Kelimeler

Calvarial hyperostosis, histopathology, clinical findings

Amerikan Pit Bull Terrier bir Köpekte Calvarial Hiperosteozis Sendromu

Öz

Kalvarial Hiperosteozis (KHO) son yıllarda
genç köpeklerde tanımlanmış olan ve nadir olarak görülen kafatası kemiğinde
şişme ile karekterize neoplastik olmayan proliferative bir kemik hastalığıdır.
Bu hastalık daha çoğunlukta genç erkek Bull Mastiff lerde bildirilmiştir.
Çalışmada, Literatürde köpeklerde nadir olarak bildirilen bu sendromun klinik
ve patolojik yönleriyle açıklanması amaçlanmıştır. Bu makale Köpeklerde
Kalvarial Hiperosteozis konusunda Türkiyede ilk yayındır. Dört aylık dişi bir
Amerikan Pit Bull Terrier köpek yüksek ateş, iştahsızlık, durgunluk ve kafada
agrılı şişlik şikayeti ile kliniğe getirildi. Kranium’un radyografik incelemesinde frontal ve parietal kemiklerde yaygın
kalınlaşma ve kemik opazitesinde belirgin artış, manyetik rezonans (MR)
görüntülenmesinde tüm kesitlerde diploe mesafesinde artış saptandı. Klinik
olarak kalvarial hiperosteozis olduğu düşünülen bu olgu , histopatolojik
inceleme ile doğrulandı. Mikroskobik incelemede ortamda geniş-kalın
trabeküllerden oluşan kompakt bir kemik yapısı saptandı. Kemiğin tam
olgunlaşmamış woven kemik ile olgunlaşmış trabeküllerden oluştuğu ve bu iki
kemik yapısı arasında bazofilik görünümde belirgin bir sement hattı saptandı. 

Anahtar Kelimeler

Kalvarial hiperosteozis, histopatoloji, klinik bulgular

Kaynakça

• Alexander, J.W., 1983. Selected skeletal dysplasias: craniomandibular osteopathy, multiple cartilaginous exostoses and hypertrophic osteodystrophy. Veterinary Clinics of North America: Small Animal Practice 13, 55-70.
• De Heer, N., Maltha, J.H.J., Van Garderen, E., 2015. Calvarial hyperostosis syndrome in a young Weimaraner dog. Vlaams Diergeneeskunding Tijdschrift 84, 154-157.
• Gensure, R.C., Makite, O., Barclay, C., 2005. A novel COLIA1 mutation in infantile cortical hyperostosis (Caffey disease) expands the spectrum of collagen-related disorders. Journal of Clinical Investigation 115, 1250-1257.
• Glorieux, F.H., 2005. Caffey disease: an unlikely collagenopathy. Journal of Clinical Investigation 115, 1142-1144.
• Gülanber, E.G., Özer, K., Gürel, A., 2001. Doberman Irkı Bir Köpekte KranioMandibular Osteopati. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 27(2), 393-400.
• Huchkowsky, S.L., 2002. Craniomandibular osteopathy in a bullmastiff. The Canadian Veterinary Journal 43(11), 883-885.
• Kamoun-Goldrat, A., Le Merrer, M., 2008. Infantile cortical hiperosteosis (Caffey disease): a review. Journal of Oral and Maxillofacial Surgery 66, 2145-2150.
• Mathes, R.L., Holmes, S.P., Coleman, K.D., Radlinsky, M.A., Moore, P.A., 2012. Calvarial hyperostosis presenting as unilateral exophthalmos in a female English Springer Spaniel. Veterinary Ophthalmology 15(4), 263-270. McConnell, J.F., Hayes A., Platt S.R., Smith K.C., 2006. Calvarial Hyperostosis syndrome in two bullmastiffs. Veterinary Radiology and Ultrasound 47(1), 72-77.
• Milli, Ü., Hazıroğlu, R., 1997. Veteriner Patoloji 1. Cilt; 3. Bölüm, Kemik hastalıları, Sayfa; 399-403., Tamer Matbaacılık, DemetEvler, Ankara Muir, P., Dubielzig, R.R., Johnson, K.A., Shelton, G.D., 1996. Hypertrophic osteodystrophy and calvarial hyperostosis. Compendium on Continuing Education for the Practicing Veterinarian 18, 143-151.
• Pastor, K.F., Boulay, J.P., Schelling S.H., Carpenter, J.L., 2000. Idiopathic heyperostosis of the calvaria in five young bullmastiffs. Journal of the American Animal Hospital Association 36(5), 439-445.
• Thompson, D.J., Rogers, W., Owen, M.C., Thompson, K.G., 2011. Idiopathic canine juvenile cranial hyperostosis in a Pit Bull Terrier. New Zeland Veterinary Journal 59(4), 201-205.
• Varallo, G.R., Lima, B.R., Raposo, T.M.M., Daleck, C.R., 2012. Craniomandibular osteopathy in English Bulldog. Arsive Veterinaria, jaboticabal, SP 28(4), 218-221.