Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi 1304-6187 Ankara EAH 10.20492/aeahtd.1327956 Obstetrics and Gynaecology Kadın Hastalıkları ve Doğum Can Triglyceride/Glucose Index (TyG) and Triglyceride/HDL-Cholesterol Ratio (TG/HDL-c) Predict Gestational Diabetes Mellitus? Trigliserit/Glikoz İndeksi (TyG) ve Trigliserit/HDL-Kolesterol Oranı (TG/HDL-c) Gestasyonel Diyabeti Tahmin Edebilir mi? https://orcid.org/0000-0002-7017-8854 Yılmaz Ergani Seval SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ETLİK ZÜBEYDE HANIM KADIN HASTALIKLARI SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ https://orcid.org/0000-0002-2186-441X İlhan Tolgay Tuyan https://orcid.org/0000-0003-0202-4981 Tokgöz Betül https://orcid.org/0000-0001-6233-4207 Bayraktar Burak https://orcid.org/0000-0002-5035-8727 Bucak Mevlüt https://orcid.org/0000-0002-8413-2064 İbanoğlu Müjde Can https://orcid.org/0000-0003-3182-4312 Yakut Yücel Kadriye https://orcid.org/0000-0002-8789-1875 Erdoğan Kadriye https://orcid.org/0000-0003-1376-5734 İskender Cantekin https://orcid.org/0000-0002-1011-3848 Üstün Yaprak 09 30 2023 56 2 117 120 07 15 2023 07 29 2023 Copyright © 2003, Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi 2003 Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi

AIM: We investigated whether measurement of triglyceride/glucose index (TyG) and triglyceride/HDL-cholesterol ratio (TG /HDL-c) in the first trimester can predict gestational diabetes mellitus (GDM).MATERIAL AND METHOD: Twenty-five patients with GDM and 52 women without GDM with normal glycemic control during pregnancy were included in the study as a control group. Both insulin-controlled diabetes and diet-controlled diabetes were included in the diagnosis of GDM. Fasting glucose and plasma lipid profiles including TG, HDL-c, TyG index, and TG /HDL-c measured in the first trimester were analyzed.RESULTS: Triglyceride values (mean 133±40 mg/dL in the gestational diabetes group, 100±54 mg/dL in the control group), TyG index (15.0±8.9 in the mean gestational diabetes group, 8.8±5.0 in the control group), and TG/HDL-C ratio (mean 3.3±2.6 in the gestational diabetes group and 1.9±2.6 in the control group) was found to be significantly higher in the GDM group (p=0.01, p=0.01, p=0.01, respectively). The optimal cutoff value for TyG index was 10.4, sensitivity was 76%, specificity was 77%, and area under the receiver characteristic curve (AUC) was 0.765 to predict GDM (p < 0.001). The optimal cutoff value for the TG /HDL-C ratio was 2.3, sensitivity was 76%, specificity was 69, AUC 0.697 to predict GDM (p=0.005). CONCLUSION: TyG and TG/HDL-C ratio measured in the first trimester are thought to predict GDM better than fasting plasma glucose.

AMAÇ: Birinci trimesterde trigliserit/glukoz indeksi (TyG) ve trigliserid/HDL-kolesterol oranı (TG /HDL-c) ölçümünün gestasyonel diyabetes mellitusu (GDM) tahmin edip edemeyeceğini araştırdık.GEREÇ VE YÖNTEM: Gebelikte GDM'li 25 hasta ve glisemik kontrolü normal olan GDM'siz 52 hasta kontrol grubu olarak çalışmaya alındı. GDM tanısına hem insülin kontrollü diyabet hem de diyet kontrollü diyabet dahil edildi. İlk trimesterde ölçülen TG, HDL-c, TyG indeksi ve TG /HDL-c'yi içeren açlık glukoz ve plazma lipid profilleri analiz edildi.BULGULAR: Trigliserit değerleri (ortalama gestasyonel diabetes grubunda 133±40 mg/dL, kontrol grubunda 100±54 mg/dL), TyG indeksi (ortalama gestasyonel diabetes grubunda 15,0±8,9, kontrol grubunda 8,8±5,0) ve TG/HDL-K oranı (ortalama gestasyonel diabetes grubunda 3,3±2,6 kontrol grubunda 1,9±2,6) GDM grubunda anlamlı olarak daha yüksek bulundu(sırasıyla p=0.01, p=0.01, p=0.01) GDM'yi öngörmek için TyG indeksi için optimal kesme değeri 10,4, duyarlılık %76, özgüllük %77 ve ROC analizinde eğri altında kalan alan (AUC) 0,765 idi (p < 0,001). GDM'yi öngörmek için TG/HDL-K oranı için optimal kesme değeri 2,3, duyarlılık %76, özgüllük 69, AUC 0,697 idi (p=0,005).SONUÇ: İlk trimesterde ölçülen TyG ve TG/HDL-C oranının GDM'yi açlık plazma glukozundan daha iyi öngördüğü düşünülmektedir.

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