PROLAKTİNOMADA KABERGOLİN VE KALP KAPAK BOZUKLUKLARI

Yıl 2019, Cilt: 52 Sayı: 1, 83 - 86, 14.03.2019

Gül Gürsoy , Berrin Demirbaş Çarmıklı

Öz

Kabergolin ergot türevi
dopamin agonisti olup hormon hipersekresyonu olan hipofiz tümörlerinde yaygın
olarak kullanılmaktadır. Parkinson hastalığında kabergolin
kullanımı, klinik olarak anlamlı kardiak kapak hastalığı gelişimi riski ile
ilişkili iken prolaktinoma ve akromegalide kabergolin tedavisi anlamlı valvulopati risk artışı ile ilişkili bulunmamıştır. Ayrıca  prolaktinomalarda  valvuler anormallik ile kabergolin kullanım
süresi veya kümülatif dozu arasında korelasyon gösterilmemiştir.

          Uzun dönem yüksek doz (>3 mg/hafta), kabergolin
tedavisi alan hastalarda valvüler anormallikleri göstermek için ekokardiografi ihtiyacı
varken, 1-2 mg/hafta dozunda kabergolin tedavisinde düzenli ekokardiografi ile
tarama gerekmez.

 

Anahtar Kelimeler

Hipofiz tümörleri, kabergolin

Kaynakça

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