Sigara İçenlerde Serum Scube-1 Düzeyleri ve Etkileyen Faktörlerin Değerlendirilmesi

Yıl 2023, , 106 - 113, 16.04.2023

Sibel Tunç Karaman , Okcan Basat

https://doi.org/10.46332/aemj.1058294

Öz

Amaç: Trombosit aktivasyonunun bir göstergesi olan Serum signal peptide-CUB-EGF domain-containing protein-1 (SCUBE-1), kardiyovasküler hastalık riskini değerlendirmek için kullanılan bir biyokimyasal belirteçtir. Bu çalışma; sigara içenlerde SCUBE-1' in plazma düzeylerinin sağlıklı kontrollere göre değişimini değerlendirmeyi ve etkileyen faktörleri belirlemeyi amaçlamıştır.

Araçlar ve Yöntem: Bu çalışma; kontrol gruplu, deneysel ve tek merkezli bir çalışma olarak tasarlandı. Çalışmaya üçüncü basa-mak bir hastanenin Sigara Bırakma Kliniği’ne başvuran 18-65 yaş arası sigara içenler ile Aile Hekimliği Polikliniği’ne başvuran ve hiç sigara içmemiş sağlıklı gönüllülerden oluşan kontrol grubu dahil edildi. Tüm katılımcıların sosyodemografik verileri ve sigara içenlerin sigara içme öyküleri ile bağımlılık düzeyleri sorgulandı. Ekshale edilen karbon monoksit (CO) seviyeleri ölçüldü. Plaz-ma SCUBE-1 seviyeleri venöz kandan alınan numunelerden çalışıldı ve karşılaştırıldı.

Bulgular: "Sigara içen" hasta grubu (n=44) ve "sigara içmeyen" kontrol grubu (n=38) olmak üzere toplam 82 kişi çalışmaya dahil edildi. Ortalama SCUBE-1 değeri sigara içenlerde 1.28±0.70 ng/ml, içmeyenlerde 1.54±1.09 ng/ml idi. SCUBE-1 açısından sigara içenler ve içmeyenler arasında istatistiksel olarak fark yoktu (p=0.500). SCUBE-1 düzeyleri ile ekshale CO düzeyi, sigara içme özellikleri ve bağımlılık düzeyleri arasında istatistiksel olarak anlamlı bir ilişki bulunmadı.

Sonuç: Plazma SCUBE-1 değeri sigara içenlerde anlamlı düzeylerde yüksek bulunmamakla birlikte kardiyovasküler hastalık riskinin ve tromboza yatkınlığın değerlendirilmesinde yararlı olup olmayacağı hususunun bu kişilerde hastalık gelişim sürecinin de inceleneceği daha ileri araştırmalar ile açıklığa kavuşturulabileceği düşünülmektedir.

Anahtar Kelimeler

Karbon monoksit, Kardiyovasküler risk, Fagerström, SCUBE-1, Sigara içimi

Evaluation of Serum Scube-1 Levels and Affecting Factors in Smokers

Öz

Purpose: Serum signal peptide-CUB-EGF domain-containing protein-1 (SCUBE-1), an indicator of platelet activation, is a bio-chemical marker used to evaluate the risk for cardiovascular diseases. This study aimed to evaluate the alteration of plasma levels of SCUBE-1 in smokers compared to healthy controls and determine the affecting factors.

Materials and Methods: This study was designed as an experimental, single-centered study with a control group. The study included smokers aged 18-65 years who were admitted to the Smoking Cessation Clinic of a tertiary hospital and a control group consisting of healthy volunteers admitted to the Family Medicine Outpatient Clinic and had never smoked. Sociodemographic data of all participants and smoking histories and addiction levels of smokers were questioned. Exhaled carbon monoxide (CO) levels were measured. Plasma SCUBE-1 levels were studied and compared from samples obtained from venous blood.

Results: A total of 82 individuals, consisting of the "smoker" patient group (n=44) and the "non-smoker" control group (n=38), were included in the study. The mean SCUBE-1 value was 1.28±0.70 ng/ml in smokers, 1.54±1.09 ng/ml in non-smokers. There was no statistical difference between groups in terms of SCUBE-1 (p=0.500). There was no statistically significant correlation between SCUBE-1 levels and exhaled CO level, smoking characteristics and addiction levels.

Conclusion: Although the plasma SCUBE-1 value was not found to be significantly higher in smokers, it is thought that whether it will be useful in the evaluation of cardiovascular disease risk and thrombosis susceptibility can be clarified with further studies that will also examine the disease development process in these people.

Anahtar Kelimeler

Carbon monoxide, Cardiovascular risk, Fagerström, SCUBE-1, Smoking

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