Secondary Antiphospholipid Antibody Syndrome Due to Systemic Lupus Erythematosus: A Case Report with Superior Mesenteric Artery Involvement

Abstract

Antiphospholipid antibody syndrome (APS); is a disease characterized by anti-phospholipid protein antibody positivity as well as recurrent vascular thrombosis and/or pregnancy loss. When no underlying disease is detected, it is classified as primary type; when there is another underlying rheumatologic disease, it is classified as secondary type. Secondary APS, most commonly develops due to systemic lupus erythematosus (SLE). We present a case of ischemic colitis due to superior mesenteric artery involvement in APS. 59-year-old female patient diagnosed with SLE had sudden-onset hematochezia and acute abdomen. Therefore, the patient underwent contrast-enhanced computed tomography angiography (CT angiography). Thrombosis was detected in the superior mesenteric artery. This case was interesting in terms of different vascular involvement and treatment strategy in the gastrointestinal tract due to APS.

Keywords

• Anti-phospholipid antibody syndrome
• ischemic colitis
• systemic lupus erythematosus

Sistemik Lupus Eritematozusa Bağlı Sekonder Antifosfolipid Antikor Sendromu: Superior Mezenterik Arter Tutulumuyla Seyreden Olgu Sunumu

Abstract

Antifosfolipid antikor sendromu (AFAS); antifosfolipid protein antikor pozitifliği yanı sıra rekurren vasküler tromboz ve/veya gebelik kayıpları ile karakterize bir hastalıktır. Altta yatan bir hastalık saptanmadığında primer tip; altta yatan başka bir romatolojik hastalık varlığında sekonder tip olarak sınıflandırılır. Sekonder AFAS, en sık sistemik lupus eritematozusa (SLE) bağlı gelişir. Burada, AFAS’ta superior mezenterik arter tutulumuna bağlı iskemik kolit vakasını sunduk. 59 yaşında SLE tanısı bulunan kadın hastaya, ani gelişen hematokezya ve akut batın kliniği olması üzerine çekilen kontrastlı bilgisayarlı tomografi anjiografide (BT-anjiografi) superior mezenterik arterde tromboz saptandı. Bu olgu AFAS’a bağlı gastrointestinal sistemdeki farklı damar tutulumu ve tedavi stratejisi açısından ilginçti.

Keywords

• Anti-fosfolipid antikor sendromu
• iskemik kolit
• sistemik lupus eritematozus

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