The Efficacy of Decreased Ovarian Reserve on in Vitro Fertilization Outcome

Abstract

Purpose: In this study, we aimed to compare the effects of microdose and antagonist regimens on IVF-ICSI outcome. Materials and Methods: The study was conducted at the Maltepe University Medical Faculty Training and Research Hospital IVF Clinic during the period of 2018 and 2022. The files of the patients were reviewed retrospectively and age, duration of infertility, basal FSH level, body mass index, antral follicle number (AFC), antimullerian hormon (AMH) level, retrieved oocyte number, metaphase 2 oocyte number, fertilization and pregnancy rates were evaluated. The patients in Group 1 (n=124) were treated by using gonadotropin releasing hormone (GnRH) microdose protocol and in Group 2 (n=136) were treated by using antagonist protocol. Results: There was no significant difference between the groups in terms of the characteristics of the patients such as age, infertility duration, basal FSH level body mass index, AFC and AMH level (p>0.05). The retrieved oocyte number, metaphase 2 oocyte number, fertilization rates and pregnancy rates were also similar (p>0.05). Conclusion: Our results demonstrated that microdose and antagonist regimens have similar effect in poor reponder women on IVF-ICSI outcome.

Keywords

• antagonist regimen
• ın vitro fertilization
• microdose protocol
• poor responder
• pregnancy

Azalmış Over Rezervinin İn Vitro Fertilizasyon Sonucu Üzerindeki Etkileri

Abstract

Amaç: Biz bu çalışmada mikrodoz ve antagonist rejimlerin IVF-ICSI sonucu üzerindeki etkilerini karşılaştırmayı amaçladık. Araçlar ve Yöntem: Çalışma 2018-2022 yılları arasında Maltepe Üniversitesi Tıp Fakültesi Eğitim ve Araştırma Hastanesi Tüp Bebek Kliniği'nde gerçekleştirildi. Hastaların dosyaları retrospektif olarak incelendi ve yaş, infertilite süresi, bazal FSH düzeyi, vücut kitle indeksi, antral folikül sayısı (AFC), antimüllerian hormon (AMH) düzeyi, toplanan oosit sayısı, metafaz 2 oosit sayısı, fertilizasyon ve gebelik oranları değerlendirildi. Grup 1'deki hastalara (n=124) gonadotropin releasing hormon (GnRH) mikrodoz protokolü, Grup 2'deki (n=136) hastalara ise antagonist protokol uygulandı. Bulgular: Hastaların yaş, infertilite süresi, bazal FSH düzeyi vücut kitle indeksi, AFC ve AMH düzeyi gibi parametreler açısından gruplar arasında anlamlı fark yoktu (p>0.05). Elde edilen oosit sayısı, metafaz 2 oosit sayısı, fertilizasyon oranları ve gebelik oranları da benzerdi (p>0.05). Sonuç: Bizim sonuçlarımız, mikrodoz ve antagonist rejimlerin zayıf yanıt veren kadınlarda IVF-ICSI sonucu üzerinde benzer etkiye sahip olduğunu göstermiştir.

Keywords

• In vitro fertilizasyon
• zayıf yanıt veren
• gebelik
• mikrodoz protokol
• antagonist rejim

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