CRP / Albümin Oranı (CAR), Sistemik İnflamasyon İndeksi (SII) ve Sistemik İnflamasyonun Toplam İndeksi (AISI): İnfluenza B Tanılı Hastalarda Yeni Prognostik Biyobelirteçler

Abstract

Amaç: İnfluenza, zamanında tanı konulup tedavi edilmediğinde çeşitli komplikasyonlara yol açabilir. Bu çalışmada, yetişkinlerde rutin kan parametrelerinden türetilen CRP/Albümin Oranı (CAR), Sistemik İnflamasyon İndeksi (SII) ve Sistemik İnflamasyonun Toplam İndeksinin (AISI), influenza enfeksiyonu için öngörücü değerini araştırmak amaçlandı. Araçlar ve Yöntem: Retrospektif ve tek merkezli bu çalışmaya, influenza B tanısıyla tetkik ve tedavi edilen 127 hasta dahil edildi. Kontrol grubu ise 120 sağlıklı kişiden oluştu. İnfluenza B tanısında hızlı antijen kitleri kullanıldı. Bulgular: Çalışmaya dahil edilen hastaların CAR ortancası 8.27 (2.12-23.63), SII ortancası 2154.45 (640.24-8090) ve AISI ortancası 1085.14 (300.91-4773.10) olarak belirlendi. Hastaneye yatışı yapılan hastalarda CAR, SII ve AISI değerleri, ayaktan tedavi alanlara göre anlamlı derecede daha yüksekti (p=0.045, p<0.001, p<0.001). Hastaneye yatış yapılan hastalar ile CAR (p<0.001, r=0.799), SII (p<0.001, r=0.827) ve AISI (p<0.001, r=0.936) arasında pozitif korelasyon bulundu. Bu indeksler, influenza B tanısı olan hastalarda kontrol grubuna kıyasla anlamlı derecede daha yüksekti (p<0.001, p<0.001, p<0.001). İnfluenza B tanısında CAR, SII ve AISI'nin cut-off değerleri ROC analizi ile belirlendi. CAR için eşik değer 2.02 (duyarlılık %100, özgüllük %100, p=0.001), SII için 633.2 (AUC=1.00, duyarlılık %100, özgüllük %100, p<0.001) ve AISI için 397.56 (AUC=0.988, duyarlılık %93.3, özgüllük %92.9, p<0.001) tespit edildi. Sonuç: Çalışmamız, invaziv olmayan, düşük maliyetli, basit ve tekrarlanabilir indeksler olarak CAR, SII ve AISI'nin influenza B'li yetişkin hastaların tanımlanması, yönetimi ve hastaneye yatış süreçlerinde belirgin bir prognostik değere sahip olduğunu göstermektedir.

Keywords

• nazofarengeal sürüntü
• negatif akut faz reaktanı
• solunum yolu
• tam kan sayımı
• viral enfeksiyon

Supporting Institution

yok

Ethical Statement

Gazi Üniversitesi Tıp Fakültesi Klinik Araştırmalar Etik Komisyonunun 09.07.2024 tarih ve 1153 karar numaralı onayı alınarak yapılmıştır.

Thanks

yok

CRP/Albumin Ratio (CAR), Systemic Inflammation Index (SII), and Aggregate Index of Systemic Inflammation (AISI): Novel Prognostic Biomarkers in Patients Diagnosed with Influenza B

Abstract

Purpose: Influenza can lead to various complications if not diagnosed and treated promptly. This study aimed to investigate the predictive value of the C-reactive protein/Albumin Ratio (CAR), Systemic Inflammation Index (SII), and Aggregate Index of Systemic Inflammation (AISI), which are derived from routine blood parameters, for influenza infection in adults. Materials and Methods: This retrospective, single-center study included 127 patients diagnosed and treated for influenza B. The control group consisted of 120 healthy individuals. Rapid antigen kits were used for the diagnosis of influenza B. Results: The median CAR, SII, and AISI values of the patients included in the study were 8.27 (2.12–23.63), 2154.45 (640.24–8090), and 1085.14 (300.91–4773.10), respectively. CAR, SII, and AISI values were significantly higher in hospitalized patients compared to those treated as outpatients (p=0.045, p<0.001, p<0.001). A positive correlation was found between hospitalization and CAR (p<0.001, r=0.799), SII (p<0.001, r=0.827), and AISI (p<0.001, r=0.936). These indices were significantly higher in patients diagnosed with influenza B compared to the control group (p<0.001 for all). Cut-off values for CAR, SII, and AISI in diagnosing influenza B were determined by ROC analysis. The threshold values were 2.02 for CAR (sensitivity 100%, specificity 100%, p=0.001), 633.2 for SII (AUC=1.00, sensitivity 100%, specificity 100%, p<0.001), and 397.56 for AISI (AUC=0.988, sensitivity 93.3%, specificity 92.9%, p<0.001). Conclusion: Our study demonstrates that CAR, SII, and AISI, as non-invasive, low-cost, simple, and reproducible indices, have significant prognostic value in identifying, managing, and determining the hospitalization processes of adult patients with influenza B.

Keywords

• complete blood count
• nasopharyngeal swab
• negative acute phase reactant
• respiratory tract
• viral ınfection

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