The Evaluation of Hemodynamic and Endocrine Response and Nesfatin-1 in Patients Undergoing Inhalation and Total Intravenous Anesthesia

Abstract

Purpose: The aim of this study was to investigate the effects of different anesthesia techniques on the surgical stress response and nesfatin-1 levels. Materials and Methods: This prospective, randomized, controlled study was conducted between March and June 2015. Ninety patients undergoing septoplasty were randomized into three groups: Desflurane + N2O (Group 1), Desflurane + Remifentanil (Group 2), and Propofol + Remifentanil (Group 3). Blood samples were collected immediately before induction, at the 30th minute in the postoperative recovery room, and at the 24th postoperative hour. Serum insulin, glucose, adrenaline, noradrenaline, cortisol, and nesfatin-1 levels were measured. Results: There were no significant differences between groups in glucose, adrenaline, noradrenaline, and nesfatin-1 levels at any time point (p > 0.05). However, insulin levels at the 24th postoperative hour were significantly higher in Group 1 compared to Group 3 (18.24 miu/ml vs. 5.52 miu/ml; p < 0.05). Cortisol levels measured at the 30th postoperative minute in Group 3 showed a significant increase compared to the other groups (10.82 μg/dl; p < 0.05). Conclusion: Different anesthesia techniques produced similar effects on hemodynamic and endocrine responses as well as nesfatin-1 levels in patients undergoing septoplasty.

Keywords

• surgical stress response
• inhalation anesthesia
• Nesfatin-1
• TIVA

Supporting Institution

Fırat University Scientific Research Projects Coordination Unit

Project Number

TF 14.55

Ethical Statement

The ethics committee permission required for this study was obtained from Fırat University Faculty of Medicine Clinical Research Ethics Committee (decision no. 12-05 dated 17.06.2014).

İnhalasyon ve Total İntravenöz Anestezi Uygulanan Hastalarda Hemodinamik, Endokrin Yanıt ve Nesfatin-1'in Değerlendirilmesi

Abstract

Amaç: Çalışmanın amacı, farklı anestezi tekniklerinin cerrahi stres yanıtı ve nesfatin-1 düzeyleri üzerindeki etkilerini araştırmaktır. Araçlar ve Yöntem: Bu çalışma, Mart-Haziran 2015 tarihleri arasında prospektif, randomize ve kontrollü olarak gerçekleştirildi. Septoplasti operasyonu geçiren 90 hasta, Desfluran + N2O (Grup 1), Desfluran + Remifentanil (Grup 2) ve Propofol + Remifentanil (Grup 3) olmak üzere üç gruba randomize edildi. Kan örnekleri indüksiyondan hemen önce, postoperatif derlenme odasında 30. dakikada ve postoperatif 24. saatte alındı. Serum insülin, glukoz, adrenalin, noradrenalin, kortizol ve nesfatin-1 düzeyleri ölçüldü. Bulgular: Gruplar arasında glukoz, adrenalin, noradrenalin ve nesfatin-1 düzeyleri açısından herhangi bir zaman noktasında anlamlı fark gözlenmedi (p > 0,05). Ancak, postoperatif 24. saatte insülin düzeyleri Grup 1’de Grup 3’e kıyasla anlamlı derecede yüksekti (sırasıyla 18,24 miu/ml ve 5,52 miu/ml; p < 0,05). Postoperatif 30. dakikada Grup 3’te ölçülen kortizol seviyeleri diğer gruplara göre anlamlı bir artış gösterdi (10,82 μg/dl; p < 0,05). Sonuç: Septoplasti geçiren hastalarda farklı anestezi teknikleri, hemodinamik ve endokrin yanıtlar ile nesfatin-1 düzeyleri üzerinde benzer etkiler göstermiştir.

Keywords

• cerrahi stres yanıt
• inhalasyon anestezisi
• Nesfatin-1
• TİVA

Supporting Institution

Fırat Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi

Project Number

TF 14.55

Ethical Statement

Bu çalışma için gerekli olan etik kurul izni, Fırat Üniversitesi Tıp Fakültesi Klinik Araştırmalar Etik Kurulu’ndan (17.06.2014 tarih ve 12-05 karar no) alınmıştır.

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