A Retrospective Observational Cohort Study on the Success of Non-Invasive Respiratory Support (NIRS) Treatments and the Factors Affecting the Success of NIRS in Coronavirus Disease-Related Acute Respiratory Distress Syndrome (ARDS)

Abstract

Purpose: Non-invasive respiratory therapy is widely used as an important part of treatment in severe cases. We aimed to determine the factors affecting the success of NIRS in Covid-19-related acute respiratory distress syndrome cases. Materials and Methods: 209 patients with severe Covid-19 infection who were hospitalised in the intensive care unit of our hospital between August 2020 and May 2021 were included in the study. The patients’ demographic information, Acute Physiology and Chronic Health Evaluation-II (APACHE-II) and Sequential Organ Failure Assessment (SOFA) scores, heart rates, acidosis, consciousness, oxygenation, respiratory rates and laboratory results were recorded and analysed. Results: Advanced age, HT, chronic obstructive pulmonary disease, high APACHE and SOFA scores, low albumin levels, high LDH levels, and low PaO2/FiO2 were found to be the factors that reduced NIRS success. Additionally, we determined that low PaO2/FiO2 and SatO2 and blood PH increased early-stage failure. Conclusion: Our findings suggest that NIRS can be an effective treatment method for Covid-19 patients and that NIRS applied in the early stages of the disease can reduce the risk of intubation and mortality.

Keywords

• coronavirus disease
• non-invasive mechanical ventilation
• respiratory distress

Koronavirüs Hastalığıyla İlgili Akut Solunum Yetmezliği Sendromu'nda Non İnvaziv Solunum Desteği Tedavilerinin Başarısı ve NIRS'nin Başarısını Etkileyen Faktörler Üzerine Retrospektif Gözlemsel Kohort Bir Çalışma

Abstract

Amaç: Non-İnvaziv solunum desteği, şiddetli vakalarda tedavinin önemli bir parçası olarak yaygın olarak kullanılmaktadır. Covid-19ile ilişkili Akut Solunum Sıkıntısı Sendromu vakalarında NIRS'nin başarısını etkileyen faktörleri belirlemeyi amaçladık. AraçlarveYöntem: Ağustos 2020 ile Mayıs 2021 tarihleri arasında hastanemizin yoğun bakım ünitesinde yatan şiddetli Covid-19enfeksiyonu olan 209 hasta çalışmaya dahil edildi. Hastaların demografik bilgileri, Akut Fizyoloji ve Kronik Sağlık DeğerlendirmesiII (APACHE-II) ve Sıralı Organ Yetmezliği Değerlendirmesi (SOFA) skorları, kalp hızları, asidoz, bilinç, oksijenasyon, solunum hızları ve laboratuvar sonuçları kaydedildi ve analiz edildi. Bulgular: İleri yaş, HT, kronik obstrüktif akciğer hastalığı, yüksek APACHE ve SOFA skorları, düşük albümin seviyeleri, yüksek LDH seviyeleri ve düşük PaO2/FiO2'nin NIRS başarısını azaltan faktörler olduğu bulundu. Ek olarak, düşük PaO2/FiO2 ve SatO2 ve kan Ph'ının erken evre başarısızlığını artırdığını belirledik. Sonuç: SonuçlarımızNIRS'nin Covid-19 hastaları için etkili bir tedavi yöntemi olabileceğinive hastalığınerken evrelerinde uygulanan NIRS'nin entübasyon ve mortalite riskini azaltabileceğini göstermiştir.

Keywords

• coronavirüs hastalığı
• invaziv olmayan mekanik ventilasyon
• solunum sıkıntısı

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