Kaptoprile bağlı gelişen akut pankreatit: Olgu sunumu

Yıl 2020, , 24 - 26, 23.04.2020

Mustafa Kaplan , Sercan Özkaçmaz

https://doi.org/10.46332/aemj.624732

Öz

45 yaşında kadın hasta sırta vuran şiddetli karın ağrısı ile başvurdu ve akut pankreatit tanısıyla interne edildi. Hikayesinde yeni başlayan hipertansiyon nedeniyle iki gün önce bir defa 50 mg kaptopril aldığı ve alkol kullanmadığı öğrenildi. Abdominal ultrasonografide safra kesesi ve safra yollarında patoloji izlenmedi. Serum trigliserid ve IG G4 düzeyleri de normal olan hastada kaptoprile bağlı akut pankreatit düşünüldü. Kaptopril kesilip başka bir grup anti-hipertansif başlanan hasta akut pankreatit tedavisi sonrası taburcu edildi. Kaptoprilin öksürük, anjiyoödem ve böbrek yetmezliği gibi bilinen yan etkilerinin dışında akut pankreatit de yapabileceği akılda tutulmalıdır.

Anahtar Kelimeler

Anjiyotensin dönüştürücü enzim inhibitörü, hipertansiyon, ilaca bağlı akut pankreatit

Captopril induced acute pancreatitis: a case report

Öz

A 45-year-old woman was admitted to the hospital with severe abdominal back pain and she was internalized with the diagnosis of acute pancreatitis. Her history revealed that she had taken captopril 50 mg once two days ago due to the new onset of hypertension. She had never used alcohol before. Abdominal ultrasonography revealed no pathology in gall bladder and bile ducts. Serum triglyceride and IG G4 levels were also normal. With these results captopril induced acute pancreatitis was considered. Captopril was discontinued and another group of anti-hypertensive drug was started. The patient was discharged after treatment of acute pancreatitis. It should be kept in mind that captopril can also cause acute pancreatitis in addition to known side effects such as cough, angioedema and renal failure.

Anahtar Kelimeler

Angiotensin converting enzyme inhibitors, hypertension, acute pancreatitis

Kaynakça

• 1. Frishman WH. The efficacy and safety of quinapril in the treatment of moderate to severe and severe hypertension: comparison to captopril. Clin Cardiol. 1990;13(7):26-31.
• 2. Schattner A, Kozak N, Friedman J. Captopril-induced jaundice: report of 2 cases and a review of 13 additional reports in the literature. Am J Med Sci. 2001;322(4):236-240.
• 3. Tosun E, Oksuzoğlu B, Topaloğlu O. Relationship between acute pancreatitis and ACE inhibitors. Acta Cardiol. 2004;59(5):571-572.
• 4. Eland IA, Sundström A, Velo GP et al. Study Group of the European Pharmacovigilance Research Group.Antihypertensive medication and the risk of acute pancreatitis: the European case-control study on drug-induced acute pancreatitis (EDIP). Scand J Gastroenterol. 2006; 41(12):1484-1490.
• 5. Iliopoulou A, Giannakopoulos G, Pagoy H, Christos T, Theodore S. Acute pancreatitis due to captopril treatment. Dig Dis Sci. 2001;46(9):1882-1883.
• 6. Jeandidier N, Klewansky M, Pinget M. Captopril-induced acute pancreatitis Diabetes Care. 1995;18(3):410-411.
• 7. Kuoppala J, Enlund H, Pulkkinen J et al. ACE inhibitors and the risk of acute pancreatitis-a population-based case-control study. Pharmacoepidemiol Drug Saf. 2017;26(7):853-857.
• 8. Maliekal J, Drake CF. Acute pancreatitis associated wıth the use of lisinopril. Ann Pharmacother. 1993;27(12):1465-1466.
• 9. Roush MK, McNutt RA, Gray TF. The adverse effect dilemma: quest for accessible information. Ann Intern Med 1991;114(4):298-299.
• 10. Standridge JB. Fulminant pancreatitis associated with lisinopril therapy. South Med J 1994;87(2):179–181.
• 11. Gershon T, Olshaker JS. Acute pancreatitis following lisinopril rechallenge. Am J Emerg Med 1998;16(5):523–524.
• 12. Griesbacher T. Kallikrein-kinin system in acute pancreatitis: potential of B2-bradykinin antagonists and kallikrein inhibitors. Pharmacology. 2000;60(3):113–120.
• 13. Yu QH, Guo JF, Chen Y, Guo XR, Du YQ, Li ZS. Captopril pretreatment protects the lung against severe acute pancreatitis induced injury via inhibiting angiotensin II production and suppressing Rho/ROCK pathway. Kaohsiung J Med Sci. 2016;32(9):439-445.
• 14. Li SL, Chen X, Zhang XW, Wu T, Ji ZZ. Protective effects of captopril against lung injury in rats with severe acute pancreatitis. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30(12):2742-2745.