Investigation of Hepatic and Splenic Shear-wave Elastography Findings in Patients with Familial Mediterranean Fever

Yıl 2025, Cilt: 9 Sayı: 1, 37 - 43, 21.04.2025

Kadir Çabalak , Muhammet Murat Çelik , Alperen Kayalı , Mete Pekdiker

https://doi.org/10.46332/aemj.1455102

Öz

Purpose: Familial Mediterranean Fever (FMF) is an autoinflammatory multisystemic disorder that may impact internal organs. This study aims to evaluate the impact of FMF on the liver and spleen utilizing shear wave elastography (SWE).

Materials and Methods: Our study included patients diagnosed with FMF according to the Tel-Hashomer criteria, aged ≥18 years, who did not have AA amyloidosis or any conditions affecting liver or spleen tissue. Electronic medical records were examined retrospectively. A radiologist with a minimum of five years of expertise in shear wave elastography conducted the procedure. Shear wave elastography results were compared between patients with FMF and healthy controls.

Results: We examined fifty-one cases of FMF (25 females, 26 males) with a mean age of 32.3 years, alongside 14 healthy persons (4 females, 10 males) with a mean age of 36.9 years. The predominant symptom was fever, observed in 98% of cases, whereas 64.7% had the M694V gene mutation. No significant difference was seen between the mean SWE values of FMF cases and the control group. A positive connection between hepatic stiffness and age was identified (r=0.319, p=0.023). The age at disease onset exhibited a correlation with hepatic stiffness and velocity (r=0.474, p=0.001; r=0.386, p=0.007, respectively).

Conclusion: A consensus on non-invasive methods to follow up patients with FMF is lacking. Further studies are necessary for the quantitative and routine application of SWE measurements in solid organs affected by inflammatory disorders, including FMF.

Anahtar Kelimeler

autoinflammatory disease, inflammation, sonoelastography

Ailevi Akdeniz Ateşi Hastalarında Karaciğer ve Dalak Shearwave Elastografi Bulgularının İncelenmesi

Öz

Amaç: Ailevi Akdeniz Ateşi (AAA), iç organları etkileyebilen otoinflamatuar multisistemik bir hastalıktır. Bu çalışma, AAA'nın karaciğer ve dalak üzerindeki etkisini shear wave elastografisi (SWE) kullanarak değerlendirmeyi amaçlamaktadır.

Araçlar ve Yöntem: Çalışmamıza Tel-Hashomer kriterlerine göre AAA tanısı alan, 18 yaş ve üzeri, amiloidoz gelişmemiş, karaciğer ya da dalak dokusunu etkileyen herhangi bir durumu olmayan hastalar dahil edilmiştir. Elektronik tıbbi kayıtlar retrospektif olarak incelenmiştir. Shear wave elastografi incelemesi en az beş yıllık SWE deneyimi olan bir radyolog tarafından yapıldı. Shear wave elastografi bulguları AAA olguları ve sağlıklı grup arasında karşılaştırıldı.

Bulgular: Yaş ortalaması 32.3 yıl olan 51 AAA olgusu (25 kadın, 26 erkek) ile yaş ortalaması 36.9 yıl olan 14 sağlıklı birey (4 kadın, 10 erkek) incelendi. En sık görülen semptom ateş olup vakaların %98'inde görülürken, %64.7'sinde M694V gen mutasyonu vardı. Hasta ve kontrol grubunun ortalama SWE değerleri arasında anlamlı bir fark bulunmadı. Karaciğer sertliği ve yaş arasında hafif pozitif bir korelasyon olduğunu saptadık (r=0.319, p=0.023). Hastalık başlangıç yaşı, hepatik sertlik (r=0.474, p=0.001) ve hepatik velosite (r=0.386, p=0.007) ile koreleydi.

Sonuç: Ailevi Akdeniz Ateşi hastalarını takip etmek için non-invaziv yöntemler konusunda bir fikir birliği bulunmamaktadır. AAA’de dahil olmak üzere enflamatuar hastalıklardan etkilenen solid organlarda SWE ölçümlerinin kantitatif ve rutin olarak uygulanması için daha fazla çalışma yapılması gerekmektedir.

Anahtar Kelimeler

inflamasyon, otoinflamatuvar hastalık, sonoelastografi

Kaynakça

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