BibTex RIS Kaynak Göster

Eosinophilic gastrointestinal disorders: Is the minimum age limit for eosinophilic gastrointestinal diseases lowering?

Yıl 2013, Cilt: 12 Sayı: 1, 22 - 26, 01.04.2013

Öz

Eosinophilic gastrointestinal disorders constitute a pathology characterized by eosinophilic infiltration of the gastrointestinal tract, the symptoms of which vary depending on the affected digestive segments and the involvement of the different layers of the digestive wall. Eosinophilic gastrointestinal diseases include subcategories such as eosinophilic esophagitis, eosinophilic gastroenteritis and eosinophilic colitis, and depending on the localization of the eosinophilia, it is possible to group them as mucosal, serosal or muscular disease. Mucosal involvement is the most common. Patients with eosinophilic esophagitis suffer from nutrition intolerance, vomiting, and dysphagia; for patients with eosinophilic gastroenteritis, complaints are abdominal pain, diarrhea and blood in stool; and for patients with eosinophilic colitis, they are typically diarrhea and lower quadrant pain. The disease is typically observed in but not limited to the 3rd to 5th decades. The main therapeutic options include steroids and dietary modification. Between 2011 and 2012, 4 patients were diagnosed in our pediatric gastroenterology department. Two were diagnosed with eosinophilic esophagitis, one with eosinophilic colitis and one with eosinophilic proctocolitis. This study aimed to review eosinophilic gastrointestinal diseases in light of the recent studies, referring to children diagnosed with eosinophilic gastrointestinal diseas

Kaynakça

  • Spergel JM .Variation in prevalence, diagnostic criteria, and initial management options for eosinophilic gastrointestinal diseases in the United States. J Pediatr Gastroenterol Nutr 2011; 52: 300-6.
  • Jo Y. Eosinophilic esophagitis: update 2012. Korean J Gastroen- terol 2012; 60: 3-12.
  • Yan BM, Shaffer EA. Primary eosinophilic disorders of the gastroin- testinal tract. Gut 2009; 58: 721-32.
  • Jawairia M, Shahzad G, Mustacchia P. Eosinophilic gastrointestinal dis- eases: review and update. ISRN Gastroenterol 2012; 2012: 463689.
  • Chehade M, Sampson HA. Epidemiology and etiology of eosino- philic esophagitis. Gastrointest Endosc Clin N Am 2008; 18: 33-44.
  • Ronkainen J, Talley NJ, Aro P, et al. Prevalence of oesophageal eosinophils and eosinophilic oesophagitis in adults: the population- based Kalixanda study. Gut 2007; 56: 615-20.
  • Basavaraju KP, Wong T. Eosinophilic oesophagitis: a common cause of dysphagia in young adults? Int J Clin Pract 2008; 62: 1096-107.
  • Hugh JF. Adult eosinophilic gastroenteritis and hypereosinophilic syndromes. World J Gastroenterol 2008; 14: 6771–3.
  • Alfadda AA, Storr MA, Shaffer EA. Eosinophilic colitis: an update on pathophysiology and treatment. Br Med Bull 2011; 100: 59-72.
  • Alley NJ. Eosinophilic gastroenteritis. In: Feldman LS, Sleisenger MH, eds. Gastrointestinal and liver disease. Philadelphia: WB Saun- ders Company, 2002; 1972-82.
  • Hurrell JM, Genta RM, Melton SD. Histopathologic diagnosis of eo- sinophilic conditions in the gastrointestinal tract. Adv Anat Pathol 2011; 18: 335-48.
  • Fleischer DM, Atkins D. Eosinophilic gastrointestinal diseases: evalu- ation of the patient with suspected eosinophilic gastrointestinal dis- ease. Immunol Allergy Clin North Am 2009; 29: 53-63.
  • Lucindo AJ, Arias A. Eosinophilic gastroenteritis. An update. Expert Rev Gastroenterol Hepatol 2012; 6: 591-601.
  • Hogan SP. Functional role of eosinophils in gastrointestinal inflam- mation. Immunol Allergy Clin North Am 2009; 29: 129.
  • Seema A, Ikuo H, Glenn T, et al. Eosinophilic gastrointestinal dis- eases—clinically diverse and histopathologically confounding. Se- min Immunopathol 2012; 34: 715-31.
  • Puglisi G, Frieri M. Update on hidden food allergens and food label- ing. Allergy Asthma Proc 2007; 28: 634–9.
  • Fleischer DM, Atkins D. Eosinophilic gastrointestinal diseases: evalu- ation of the patient with suspected eosinophilic gastrointestinal dis- ease. Immunol Allergy Clin North Am 2009; 29: 53-63.
  • Straumann A, Simon HU. The physiological and pathophysiological roles of eosinophils in the gastrointestinal tract. Allergy 2004; 59: 15-25.
  • Khan S, Orenstein SR. Eosinophilic gastroenteritis: epidemiology, diagnosis and management. Paediatr Drugs 2002; 4: 563–70.
  • Schroeder S, Fleischer DM, Masterson JC, et al. Successful treat- ment of eosinophilic esophagitis with ciclesonide. J Allergy Clin Im- munol 2012; 129: 1419-21.
  • Liacouras CA. Pharmacologic treatment of eosinophilic esophagitis. Gastrointest Endosc Clin N Am 2008; 18: 169-78.
  • Rothenberg ME. Eosinophilic gastrointestinal disorders. J Allerg Clin Immunol 2004; 113: 11-28.
  • Stein ML, Collins MH, Villanueva JM, et al. Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis. J Allergy Clin Immunol 2006; 118: 1312.
  • Garn H, Renz H. Epidemiological and immunological evidence for the hygiene hypothesis. Immunobiology 2007; 212: 441–52.
  • Furuta GT, Forbes D, Boey C, et al. Eosinophilic gastrointestinal diseases (EGIDs). J Pediatr Gastroenterol Nutr 2008; 47: 234–8.
  • Syed AA, Andrews CN, Shaffer E, et al. The rising incidence of eo- sinophilic oesophagitis is associated with increasing biopsy rates. A population-based study. Aliment Pharmacol Ther 2012; 36: 950-8.
  • Kim NI, Jo YJ, Song MH, et al. Clinical features of eosinophilic gas- troenteritis in Korean. Korean J Gastroenterol 2004; 44: 217-23.
  • Chen MJ, Chu CH, Lin SC, et al. Eosinophilic gastroenteritis: clinical experience with 15 patients. World J Gastroenterol 2003; 9: 2813-6.
  • Venkataraman S, Ramakrishna BS, Mathan M, et al. Eosinophilic gastro- enteritis--an Indian experience. Indian J Gastroenterol 1998; 17: 148-9.

Eosinofilik gastointestinal hastalıklar: Eosinofilik gastro intestinal hastalıkların görülme yaşı küçülüyor mu?

Yıl 2013, Cilt: 12 Sayı: 1, 22 - 26, 01.04.2013

Öz

Eozinofilik gastrointestinal hastalıklar gastrointestinal kanalın eozinofilik infiltrasyonu ile karakterizedir. Hastalığın belirtileri etkilenen sindirim segmentine ve sindirim kanalının farklı tabakalarının tutulumuna bağlı olarak değişiklik gösterir. Eozinofilik gastrointestinal hastalıklar, eozinofilik özofajit, eozinofilik gastroenterit ve eozinofilik kolit gibi alt gruplara ayrılır. Eozinofilinin yerleşimine bağlı olarak mukozal, serozal ya da müsküler hastalık olarak gruplamak mümkündür. Mukozal hastalıklar bunların arasında en yaygın olanıdır. Eozinofilik özofajitli hastalar hazımsızlık, kusma, disfaji şikayetleri gösterirken, eozinofilik gastroenterit hastaları karın ağrısı, ishal ve kanlı dışkılama şikayetlerine sahiptir. Eozinofilik kolitli hastalarda ise tipik olarak ishal ve alt kadran ağrısı şikayetlerine rastlanır. Hastalık tipik olarak 3. ve 5. dekatlarda görülmekle birlikte diğer yaş gruplarında da görülebilir. Ana tedavi seçenekleri arasında steroid ve diyet değişikliği vardır. 2011 ile 2012 yılları arasında çocuk gastroenteroloji bölümümüzde 4 hastaya eozinofilik gastrointestinal hastalık tanısı konuldu. Bunlardan 2 tanesi eozinofilik özofajit, 1 tanesi eozinofilik kolit, diğeri ise eozinofilik proktokolit tanısı aldı. Bu makalede eozinofilik gastrointestinal hastalık tanısı almış çocuk hastalarımız güncel çalışmalar ışığında gözden geçirildi.

Kaynakça

  • Spergel JM .Variation in prevalence, diagnostic criteria, and initial management options for eosinophilic gastrointestinal diseases in the United States. J Pediatr Gastroenterol Nutr 2011; 52: 300-6.
  • Jo Y. Eosinophilic esophagitis: update 2012. Korean J Gastroen- terol 2012; 60: 3-12.
  • Yan BM, Shaffer EA. Primary eosinophilic disorders of the gastroin- testinal tract. Gut 2009; 58: 721-32.
  • Jawairia M, Shahzad G, Mustacchia P. Eosinophilic gastrointestinal dis- eases: review and update. ISRN Gastroenterol 2012; 2012: 463689.
  • Chehade M, Sampson HA. Epidemiology and etiology of eosino- philic esophagitis. Gastrointest Endosc Clin N Am 2008; 18: 33-44.
  • Ronkainen J, Talley NJ, Aro P, et al. Prevalence of oesophageal eosinophils and eosinophilic oesophagitis in adults: the population- based Kalixanda study. Gut 2007; 56: 615-20.
  • Basavaraju KP, Wong T. Eosinophilic oesophagitis: a common cause of dysphagia in young adults? Int J Clin Pract 2008; 62: 1096-107.
  • Hugh JF. Adult eosinophilic gastroenteritis and hypereosinophilic syndromes. World J Gastroenterol 2008; 14: 6771–3.
  • Alfadda AA, Storr MA, Shaffer EA. Eosinophilic colitis: an update on pathophysiology and treatment. Br Med Bull 2011; 100: 59-72.
  • Alley NJ. Eosinophilic gastroenteritis. In: Feldman LS, Sleisenger MH, eds. Gastrointestinal and liver disease. Philadelphia: WB Saun- ders Company, 2002; 1972-82.
  • Hurrell JM, Genta RM, Melton SD. Histopathologic diagnosis of eo- sinophilic conditions in the gastrointestinal tract. Adv Anat Pathol 2011; 18: 335-48.
  • Fleischer DM, Atkins D. Eosinophilic gastrointestinal diseases: evalu- ation of the patient with suspected eosinophilic gastrointestinal dis- ease. Immunol Allergy Clin North Am 2009; 29: 53-63.
  • Lucindo AJ, Arias A. Eosinophilic gastroenteritis. An update. Expert Rev Gastroenterol Hepatol 2012; 6: 591-601.
  • Hogan SP. Functional role of eosinophils in gastrointestinal inflam- mation. Immunol Allergy Clin North Am 2009; 29: 129.
  • Seema A, Ikuo H, Glenn T, et al. Eosinophilic gastrointestinal dis- eases—clinically diverse and histopathologically confounding. Se- min Immunopathol 2012; 34: 715-31.
  • Puglisi G, Frieri M. Update on hidden food allergens and food label- ing. Allergy Asthma Proc 2007; 28: 634–9.
  • Fleischer DM, Atkins D. Eosinophilic gastrointestinal diseases: evalu- ation of the patient with suspected eosinophilic gastrointestinal dis- ease. Immunol Allergy Clin North Am 2009; 29: 53-63.
  • Straumann A, Simon HU. The physiological and pathophysiological roles of eosinophils in the gastrointestinal tract. Allergy 2004; 59: 15-25.
  • Khan S, Orenstein SR. Eosinophilic gastroenteritis: epidemiology, diagnosis and management. Paediatr Drugs 2002; 4: 563–70.
  • Schroeder S, Fleischer DM, Masterson JC, et al. Successful treat- ment of eosinophilic esophagitis with ciclesonide. J Allergy Clin Im- munol 2012; 129: 1419-21.
  • Liacouras CA. Pharmacologic treatment of eosinophilic esophagitis. Gastrointest Endosc Clin N Am 2008; 18: 169-78.
  • Rothenberg ME. Eosinophilic gastrointestinal disorders. J Allerg Clin Immunol 2004; 113: 11-28.
  • Stein ML, Collins MH, Villanueva JM, et al. Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis. J Allergy Clin Immunol 2006; 118: 1312.
  • Garn H, Renz H. Epidemiological and immunological evidence for the hygiene hypothesis. Immunobiology 2007; 212: 441–52.
  • Furuta GT, Forbes D, Boey C, et al. Eosinophilic gastrointestinal diseases (EGIDs). J Pediatr Gastroenterol Nutr 2008; 47: 234–8.
  • Syed AA, Andrews CN, Shaffer E, et al. The rising incidence of eo- sinophilic oesophagitis is associated with increasing biopsy rates. A population-based study. Aliment Pharmacol Ther 2012; 36: 950-8.
  • Kim NI, Jo YJ, Song MH, et al. Clinical features of eosinophilic gas- troenteritis in Korean. Korean J Gastroenterol 2004; 44: 217-23.
  • Chen MJ, Chu CH, Lin SC, et al. Eosinophilic gastroenteritis: clinical experience with 15 patients. World J Gastroenterol 2003; 9: 2813-6.
  • Venkataraman S, Ramakrishna BS, Mathan M, et al. Eosinophilic gastro- enteritis--an Indian experience. Indian J Gastroenterol 1998; 17: 148-9.
Toplam 29 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Eylem Sevinç Bu kişi benim

Gülten Can Sezgin - Bu kişi benim

Alper Yurci - Bu kişi benim

Duran Arslan Bu kişi benim

Şebnem Gürsoy Bu kişi benim

Sıraç Erten Bu kişi benim

Yayımlanma Tarihi 1 Nisan 2013
Yayımlandığı Sayı Yıl 2013 Cilt: 12 Sayı: 1

Kaynak Göster

APA Sevinç, E., -, G. C. S., -, A. Y., Arslan, D., vd. (2013). Eosinofilik gastointestinal hastalıklar: Eosinofilik gastro intestinal hastalıkların görülme yaşı küçülüyor mu?. Akademik Gastroenteroloji Dergisi, 12(1), 22-26.

test-5