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Çölyak hastalığında Helicobacter pylori enfeksiyonu sıklığı

Yıl 2024, Cilt: 23 Sayı: 1, 1 - 5, 25.04.2024
https://doi.org/10.17941/agd.1338538

Öz

Giriş ve Amaç: Helicobacter pylori tüm dünyada ve Türkiye'de en yaygın kronik enfeksiyon etkenidir ve ülkemizdeki prevalansı %80'ler civarındadır. Öncelikle mide mukozasına tutunarak çeşitli gastroduodenal hastalıklara yol açmaktadır. Peptik ülser, gastrik MALT lenfoma, gastrik adenokanser gibi hastalıkları artırdığı bilinmekle birlikte, astım, eozinofilik özofajit ve çölyak hastalığı gibi bazı hastalıklara karşı da koruyucu olabileceği düşünülmektedir. Biz de bu çalışmamızda kliniğimizde takipli çölyak hastalarında Helicobacter pylori sıklığını değerlendirmeyi amaçladık. Gereç ve Yöntem: Çalışmaya histolojik inceleme ile tanı almış 90 çölyak hastası dahil edildi. Kontrol grubu olarak herhangi bir nedenle üst gastrointestinal sistem endoskopileri yapılarak biyopsileri yapılmış 108 hasta alındı. Hasta ve kontrol gruplarına ait veriler retrospektif olarak incelendi. Bulgular: Çölyak hastaları arasında Helicobacter pylori 90 hastadan 37’sinde (%41.1) pozitif, kontrol grubunda 108 hastadan 63’ünde (%58.3) pozitif saptandı. Çölyak hasta grubunda Helicobacter pylori sıklığı kontrol grubuna oranla anlamlı olarak daha azdı (p: 0.016). Sonuç: Çölyak hastalığı olanlarda Helicobacter pylori sıklığı literatür verileriyle de uyumlu olarak olmayanlara göre anlamlı düzeyde düşük saptanmıştır. Bu durum Helicobacter pylori varlığının çölyak hastalığı üzerine koruyucu etkileri olabileceği yönündeki fikirleri desteklemektedir. Bu ilişkinin netleştirilmesi ve olası mekanizmaların belirlenebilmesi için ileri çalışmalara halen ihtiyaç duyulmaktadır.

Kaynakça

  • 1. Caio G, Volta U, Sapone A, et al. Celiac disease: a comprehensive current review. BMC Med 2019;17:142.
  • 2. Demirçeken FG. Gluten enteropatisi (çölyak hastalığı): Klasik bir öykü ve güncel gelişmeler. Güncel Gastroenteroloji. 2011;15:58-72.
  • 3. Singh P, Arora A, Strand TA, et al. Global prevalence of celiac disease: Systematic review and meta-analysis. Clin Gastroenterol Hepatol 2018;16:823-36 e2.
  • 4. Kaya M, Şipal S, Polat U, Sezikli M. Frequency of vitamin D deficiency and osteoporosis in celiac patients. Kocaeli Med J. 2019;8:80-8.
  • 5. Hujoel IA, Reilly NR, Rubio-Tapia A. Celiac disease: Clinical features and diagnosis. Gastroenterol Clin North Am 2019;48:19-37.
  • 6. Sergi C, Shen F, Bouma G. Intraepithelial lymphocytes, scores, mimickers and challenges in diagnosing gluten-sensitive enteropathy (celiac disease). World J Gastroenterol 2017;23:573-89.
  • 7. Hooi JKY, Lai WY, Ng WK, et al. Global prevalence of Helicobacter pylori infection: Systematic review and meta-analysis. Gastroenterology 2017;153:420-9.
  • 8. Ozaydin N, Turkyilmaz SA, Cali S. Prevalence and risk factors of Helicobacter pylori in Turkey: a nationally-representative, cross-sectional, screening with the ¹³C-Urea breath test. BMC Public Health 2013;13:1215.
  • 9. Bor S, Kitapcioglu G, Kasap E. Prevalence of gastroesophageal reflux disease in a country with a high occurrence of Helicobacter pylori. World J Gastroenterol 2017;23:525-32.
  • 10. Kaplan M, Tanoglu A, Duzenli T, et al. Helicobacter pylori treatment in Turkey: Current status and rational treatment options. North Clin Istanb 2020;7:87-94.
  • 11. Hasni S, Ippolito A, Illei G. Helicobacter pylori and autoimmune diseases. Oral Dis 2011;17:621-7.
  • 12. Lasa J, Zubiaurre I, Dima G, Peralta D, Soifer L. Helicobacter pylori prevalence in patients with celiac disease: results from a cross-sectional study. Arq Gastroenterol 2015;52:139-42.
  • 13. Lebwohl B, Blaser MJ, Ludvigsson JF, et al. Decreased risk of celiac disease in patients with Helicobacter pylori colonization. Am J Epidemiol 2013;178:1721-30.
  • 14. Villanacci V, Bassotti G, Liserre B, et al. Helicobacter pylori infection in patients with celiac disease. Am J Gastroenterol 2006;101:1880-5.
  • 15. Narang M, Puri AS, Sachdeva S, et al. Celiac disease and Helicobacter pylori infection in children: Is there any Association? J Gastroenterol Hepatol 2017;32:1178-82.
  • 16. Aydogdu S, Cakir M, Yuksekkaya HA, et al. Helicobacter pylori infection in children with celiac disease. Scand J Gastroenterol 2008;43:1088-93.
  • 17. Konturek PC, Karczewska E, Dieterich W, Hahn EG, Schuppan D. Increased prevalence of Helicobacter pylori infection in patients with celiac disease. Am J Gastroenterol 2000;95:3682-3.
  • 18. Konakçı N, Gülten M, İbanoğlu MS, et al. Kronik aktif gastritli olgularda Helicobacter pylori sıklığı. Uludağ Tıp Derg 2010;36:7-10.
  • 19. Arnold IC, Dehzad N, Reuter S, et al. Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells. J Clin Invest 2011;121:3088-93.
  • 20. Malfertheiner P, Megraud F, O'Morain C, et al. Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report. Gut 2007;56:772-81.

Frequency of Helicobacter pylori infection in celiac disease

Yıl 2024, Cilt: 23 Sayı: 1, 1 - 5, 25.04.2024
https://doi.org/10.17941/agd.1338538

Öz

Background and Aims: Helicobacter pylori is the most common chronic infection agent all over the world and in Turkey, and its prevalence in our country is around 80%. It primarily penetrates the gastric mucosa, causing various gastroduodenal diseases. Although it is known to increase diseases such as peptic ulcer, gastric MALT lymphoma, gastric adenocancer, it is thought to be protective against some diseases such as asthma, eosinophilic esophagitis and celiac. In this study, we aimed to evaluate the frequency of Helicobacter pylori in celiac patients followed up in our clinic. Materials and Methods: Ninety celiac patients diagnosed with histological examination were included in the study. As the control group, 108 patients who underwent upper gastrointestinal system endoscopies and biopsies for any reason were included. The data of the patient and control groups were analyzed retrospectively. Results: Among celiac patients, Helicobacter pylori was positive in 37 (41.1%) of 90 patients, and positive in 63 (58.3%) of 108 patients in the control group. The frequency of Helicobacter pylori in the celiac patient group was significantly lower than in the control group (p: 0.016). Conclusion: The frequency of Helicobacter pylori in patients with celiac disease was found to be significantly lower than those without, which is consistent with the literature data. This supports the idea that the presence of Helicobacter pylori may have protective effects on celiac disease. Further studies are still needed to clarify this relationship and identify possible mechanisms.

Kaynakça

  • 1. Caio G, Volta U, Sapone A, et al. Celiac disease: a comprehensive current review. BMC Med 2019;17:142.
  • 2. Demirçeken FG. Gluten enteropatisi (çölyak hastalığı): Klasik bir öykü ve güncel gelişmeler. Güncel Gastroenteroloji. 2011;15:58-72.
  • 3. Singh P, Arora A, Strand TA, et al. Global prevalence of celiac disease: Systematic review and meta-analysis. Clin Gastroenterol Hepatol 2018;16:823-36 e2.
  • 4. Kaya M, Şipal S, Polat U, Sezikli M. Frequency of vitamin D deficiency and osteoporosis in celiac patients. Kocaeli Med J. 2019;8:80-8.
  • 5. Hujoel IA, Reilly NR, Rubio-Tapia A. Celiac disease: Clinical features and diagnosis. Gastroenterol Clin North Am 2019;48:19-37.
  • 6. Sergi C, Shen F, Bouma G. Intraepithelial lymphocytes, scores, mimickers and challenges in diagnosing gluten-sensitive enteropathy (celiac disease). World J Gastroenterol 2017;23:573-89.
  • 7. Hooi JKY, Lai WY, Ng WK, et al. Global prevalence of Helicobacter pylori infection: Systematic review and meta-analysis. Gastroenterology 2017;153:420-9.
  • 8. Ozaydin N, Turkyilmaz SA, Cali S. Prevalence and risk factors of Helicobacter pylori in Turkey: a nationally-representative, cross-sectional, screening with the ¹³C-Urea breath test. BMC Public Health 2013;13:1215.
  • 9. Bor S, Kitapcioglu G, Kasap E. Prevalence of gastroesophageal reflux disease in a country with a high occurrence of Helicobacter pylori. World J Gastroenterol 2017;23:525-32.
  • 10. Kaplan M, Tanoglu A, Duzenli T, et al. Helicobacter pylori treatment in Turkey: Current status and rational treatment options. North Clin Istanb 2020;7:87-94.
  • 11. Hasni S, Ippolito A, Illei G. Helicobacter pylori and autoimmune diseases. Oral Dis 2011;17:621-7.
  • 12. Lasa J, Zubiaurre I, Dima G, Peralta D, Soifer L. Helicobacter pylori prevalence in patients with celiac disease: results from a cross-sectional study. Arq Gastroenterol 2015;52:139-42.
  • 13. Lebwohl B, Blaser MJ, Ludvigsson JF, et al. Decreased risk of celiac disease in patients with Helicobacter pylori colonization. Am J Epidemiol 2013;178:1721-30.
  • 14. Villanacci V, Bassotti G, Liserre B, et al. Helicobacter pylori infection in patients with celiac disease. Am J Gastroenterol 2006;101:1880-5.
  • 15. Narang M, Puri AS, Sachdeva S, et al. Celiac disease and Helicobacter pylori infection in children: Is there any Association? J Gastroenterol Hepatol 2017;32:1178-82.
  • 16. Aydogdu S, Cakir M, Yuksekkaya HA, et al. Helicobacter pylori infection in children with celiac disease. Scand J Gastroenterol 2008;43:1088-93.
  • 17. Konturek PC, Karczewska E, Dieterich W, Hahn EG, Schuppan D. Increased prevalence of Helicobacter pylori infection in patients with celiac disease. Am J Gastroenterol 2000;95:3682-3.
  • 18. Konakçı N, Gülten M, İbanoğlu MS, et al. Kronik aktif gastritli olgularda Helicobacter pylori sıklığı. Uludağ Tıp Derg 2010;36:7-10.
  • 19. Arnold IC, Dehzad N, Reuter S, et al. Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells. J Clin Invest 2011;121:3088-93.
  • 20. Malfertheiner P, Megraud F, O'Morain C, et al. Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report. Gut 2007;56:772-81.
Toplam 20 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Gastroenteroloji ve Hepatoloji
Bölüm Makaleler
Yazarlar

Muhammed Kaya Bu kişi benim 0000-0002-7514-1962

Melis Bektaş Bu kişi benim 0000-0001-9260-1249

Mesut Sezikli Bu kişi benim 0000-0002-0943-3756

Yayımlanma Tarihi 25 Nisan 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 23 Sayı: 1

Kaynak Göster

APA Kaya, M., Bektaş, M., & Sezikli, M. (2024). Çölyak hastalığında Helicobacter pylori enfeksiyonu sıklığı. Akademik Gastroenteroloji Dergisi, 23(1), 1-5. https://doi.org/10.17941/agd.1338538

test-5