Effect of donor graft hepatosteatosis on postoperative complications in adult living donor liver transplant recipients

Yıl 2024, Cilt: 23 Sayı: 1, 13 - 19, 25.04.2024

Ender Anılır , Feyza Sönmez Topcu , Emrah Şahin , Alihan Oral , Esra Güzelaltunçekiç , Abuzer Dirican , Bülent Ünal

https://doi.org/10.17941/agd.1459441

Öz

Background and Aims: Steatosis is one of today's important and common donor liver problems, affecting graft function to varying degrees and leading to marginal graft failure. We examined the effect of graft steatosis on postoperative complications, in our study. Material and Methods: One hundred forty eight donors and adult living donor liver transplant recipients who underwent transplantation were included in the study. The numbers and rates of perioperative blood product transfusion, postoperative biliary complications, hepatic vein thrombosis, portal vein thrombosis, postoperative bleeding, sepsis and primary graft dysfunction were analyzed statistically. Results: Early postoperative intra-abdominal bleeding was observed to be more common in fatty grafts, with a rate of 10.5%, than in non-fat grafts, with a rate of 4.5%. There was no statistically significant difference between those with and without donor graft steatosis. Conclusion: Although not statistically significant, the high rate of postoperative intra-abdominal bleeding in fatty grafts may be an important finding.

Anahtar Kelimeler

Liver, graft, steatozis, transplantation, donor

Donör graft hepatosteatozunun yetişkin canlı donör karaciğer nakli alıcılarında ameliyat sonrası komplikasyonlara etkisi

Öz

Giriş ve Amaç: Steatoz, greft fonksiyonunu değişen derecelerde etkileyen ve marjinal greft yetmezliğine neden olan günümüzün önemli ve yaygın donör karaciğer problemlerinden biridir. Çalışmamızda, greft steatozunun postoperatif komplikasyonlara etkisini inceledik. Gereç ve Yöntem: Çalışmaya 148 donör ve transplantasyon yapılan yetişkin canlı donör karaciğer nakli alıcısı dahil edildi. Perioperatif kan ürünü transfüzyonu, postoperatif safra komplikasyonları, hepatik ven trombozu, portal ven trombozu, postoperatif kanama, sepsis ve primer greft disfonksiyonu sayıları ve oranları istatistiksel olarak analiz edildi. Bulgular: Ameliyat sonrası erken dönemde intraabdominal kanamanın yağlı greftlerde oran olarak, yağsız greftlere göre daha sık olduğu görüldü. Donör greft steatozu olan ve olmayanlar arasında tüm parametreler açısından istatistiksel olarak anlamlı fark yoktu. Sonuç: İstatistiksel olarak anlamlı olmasa da yağlı greftlerde ameliyat sonrası intraabdominal kanama oranının yüksek olması önemli bir bulgu olabilir.

Anahtar Kelimeler

Karaciğer, greft, steatoz, transplantasyon, donör

Kaynakça

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