ağrı med j

Ağrı Tıp Fakültesi Dergisi

2980-0978

Ağrı İbrahim Çeçen Üniversitesi

10.61845/agrimedical.1503465

Biochemistry and Cell Biology (Other)

Biyokimya ve Hücre Biyolojisi (Diğer)

Metal Zehirlenmeleri ve Şelasyon Tedavisi

Metal Poisoning and Chelation Therapy

https://orcid.org/0009-0007-9110-4428

Buluz

Pınar

Bozkır İlçe Milli Eğitim Müdürlüğü

https://orcid.org/0000-0002-5481-1111

Başpınar

Nuri

SELÇUK ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ

10 30 2024

2 3 126 131 06 22 2024 10 07 2024

2023

Ağrı Tıp Fakültesi Dergisi

Yarım yüzyıldan fazla süren klinik deneyime rağmen, toksik ağır metallere yönelik şelasyon, klinik toksikolojide en tartışmalı ve yanlış uygulanan müdahalelerden biridir. Spesifik şelatların doğru kullanımının genel destekleyici bakımla birleştirildiğinde ciddi zehirlenmelerle ilişkili morbidite ve mortaliteyi azalttığına dair yeterli kanıt vardır. Bu derlemede, beş ağır metal (civa, kurşun, arsenik, kadmiyum, bakır) intoksikasyonunun tedavisi için mevcut şelasyon ajanları ve tedavi stratejileri hakkında bir güncelleme sunuyoruz.

Despite more than half a century of clinical experience, chelation for toxic heavy metals remains one of the most controversial and misapplied interventions in clinical toxicology. There is sufficient evidence that the proper use of specific chelates, when combined with general supportive care, reduces the morbidity and mortality associated with serious poisonings. In this review, we provide an update on available chelation agents and treatment strategies for the treatment of five heavy metal (mercury, lead, arsenic, cadmium, copper) intoxications.

metal zehirlenme civa arseik kurşun kadmiyum bakır şelasyon

metal chelation mercury copper lead Cadmiyum arsenic

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