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            <front>

                <journal-meta>
                                                                <journal-id>ağrı med j</journal-id>
            <journal-title-group>
                                                                                    <journal-title>Ağrı Tıp Fakültesi Dergisi</journal-title>
            </journal-title-group>
                                        <issn pub-type="epub">2980-0978</issn>
                                                                                            <publisher>
                    <publisher-name>Ağrı İbrahim Çeçen Üniversitesi</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id pub-id-type="doi">10.61845/agrimedical.1782782</article-id>
                                                                <article-categories>
                                            <subj-group  xml:lang="en">
                                                            <subject>Allergy</subject>
                                                    </subj-group>
                                            <subj-group  xml:lang="tr">
                                                            <subject>Alerji</subject>
                                                    </subj-group>
                                    </article-categories>
                                                                                                                                                        <title-group>
                                                                                                                        <trans-title-group xml:lang="en">
                                    <trans-title>Chronic spontaneous urticaria: Current approaches and the importance of awareness</trans-title>
                                </trans-title-group>
                                                                                                                                                                                                <article-title>Kronik spontan ürtiker: Güncel yaklaşımlar ve farkındalığın önemi</article-title>
                                                                                                    </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0002-0810-087X</contrib-id>
                                                                <name>
                                    <surname>Cihanbeylerden</surname>
                                    <given-names>Melek</given-names>
                                </name>
                                                                    <aff>HACETTEPE UNIVERSITY</aff>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="20251029">
                    <day>10</day>
                    <month>29</month>
                    <year>2025</year>
                </pub-date>
                                        <volume>3</volume>
                                        <issue>3</issue>
                                        <fpage>158</fpage>
                                        <lpage>159</lpage>
                        
                        <history>
                                    <date date-type="received" iso-8601-date="20250912">
                        <day>09</day>
                        <month>12</month>
                        <year>2025</year>
                    </date>
                                                    <date date-type="accepted" iso-8601-date="20251024">
                        <day>10</day>
                        <month>24</month>
                        <year>2025</year>
                    </date>
                            </history>
                                        <permissions>
                    <copyright-statement>Copyright © 2023, Ağrı Tıp Fakültesi Dergisi</copyright-statement>
                    <copyright-year>2023</copyright-year>
                    <copyright-holder>Ağrı Tıp Fakültesi Dergisi</copyright-holder>
                </permissions>
            
                                                                                                <trans-abstract xml:lang="en">
                            <p>Since this manuscript is a letter to the editor, no abstract is required in accordance with the journal’s instructions for authors.</p></trans-abstract>
                                                                                                                                    <abstract><p>Bu makale editöre mektup niteliğindedir ve derginin yazarlara yönelik talimatları uyarınca özet gerektirmemektedir.</p></abstract>
                                                            
            
                                                                                        <kwd-group>
                                                    <kwd>Anjioödem</kwd>
                                                    <kwd>  Antihistaminik</kwd>
                                                    <kwd>  Mast hücresi</kwd>
                                                    <kwd>  Omalizumab</kwd>
                                                    <kwd>  Siklosporin</kwd>
                                                    <kwd>  Ürtiker</kwd>
                                            </kwd-group>
                            
                                                <kwd-group xml:lang="en">
                                                    <kwd>Angioedema</kwd>
                                                    <kwd>  Antihistamine</kwd>
                                                    <kwd>  Cyclosporine</kwd>
                                                    <kwd>  Mast cell</kwd>
                                                    <kwd>  Omalizumab</kwd>
                                                    <kwd>  Urticaria</kwd>
                                            </kwd-group>
                                                                                                                                        </article-meta>
    </front>
    <back>
                            <ref-list>
                                    <ref id="ref1">
                        <label>1</label>
                        <mixed-citation publication-type="journal">Kocatürk E, Chu DK, Türk M, et al. Management of chronic spontaneous urticaria made practical: what every clinician should know.  J Allergy Clin Immunol Pract. 2025;13(9):2252-2269.</mixed-citation>
                    </ref>
                                    <ref id="ref2">
                        <label>2</label>
                        <mixed-citation publication-type="journal">Zuberbier T, Ensina LF, Giménez-Arnau A, et al. Chronic urticaria: unmet needs, emerging drugs, and new perspectives on personalized treatment. Lancet. 2024;404(10450):393-404.</mixed-citation>
                    </ref>
                                    <ref id="ref3">
                        <label>3</label>
                        <mixed-citation publication-type="journal">Kolkhir P, Muñoz M, Asero R, et al. Autoimmune chronic spontaneous urticaria. J Allergy Clin Immunol. 2022;149(6):1819-31.</mixed-citation>
                    </ref>
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                        <label>4</label>
                        <mixed-citation publication-type="journal">Zuberbier T, Abdul Latiff AH, Abuzakouk M, et al. The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria. Allergy. 2022;77(3):734-766.</mixed-citation>
                    </ref>
                                    <ref id="ref5">
                        <label>5</label>
                        <mixed-citation publication-type="journal">Weller K, Groffik A, Church MK, et al. Development and validation of the Urticaria Control Test: a patient-reported outcome instrument for assessing urticaria control. J Allergy Clin Immunol. 2014;133(5):1365-72.e6.</mixed-citation>
                    </ref>
                                    <ref id="ref6">
                        <label>6</label>
                        <mixed-citation publication-type="journal">Xiao X, Xue P, Shi Y, et al. The efficacy and safety of high-dose non-sedating antihistamines in chronic spontaneous urticaria: a systematic review and meta-analysis of randomized clinical trials. BMC Pharmacol Toxicol. 2023;24(1):23.</mixed-citation>
                    </ref>
                                    <ref id="ref7">
                        <label>7</label>
                        <mixed-citation publication-type="journal">Maurer M, Rosén K, Hsieh H-J, et al. Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria. N Engl J Med. 2013;368(10):924-35.</mixed-citation>
                    </ref>
                                    <ref id="ref8">
                        <label>8</label>
                        <mixed-citation publication-type="journal">Soegiharto R, Aghdam MA, Sørensen JA, et al. Multinational drug survival study of omalizumab in patients with chronic urticaria and potential predictors for discontinuation. JAMA Dermatol. 2024;160(9):927-35.</mixed-citation>
                    </ref>
                                    <ref id="ref9">
                        <label>9</label>
                        <mixed-citation publication-type="journal">Türk M, Kocatürk E, Ertaş R, et al. A global perspective on stepping down chronic spontaneous urticaria treatment: results of the Urticaria Centers of Reference and Excellence SDown-CSU study. Clin Transl Allergy. 2024;14(2):e12343.</mixed-citation>
                    </ref>
                                    <ref id="ref10">
                        <label>10</label>
                        <mixed-citation publication-type="journal">Kulthanan K, Chaweekulrat P, Komoltri C, et al. Cyclosporine for chronic spontaneous urticaria: a meta-analysis and systematic review. J Allergy Clin Immunol Pract. 2018;6(2):586-99.</mixed-citation>
                    </ref>
                            </ref-list>
                    </back>
    </article>
