Review on Menopause and Immunity

Yıl 2025, Cilt: 34 Sayı: 2, 156 - 161, 30.06.2025

Ayşe Nur Çakır Güngör , Aslıhan Candevir

https://doi.org/10.17827/aktd.1637408

Öz

Menopausal transition is one of the important life events in a woman’s life. Menopausal symptoms are primarily caused by estrogen insufficiency. Estrogen deficiency also causes long-term problems like osteoporosis and an increment of cardiovascular events, and it might have some impact on immunity and vice versa.
In this review we will summarize the effect of menopause and the immune system on each other and elaborate on the relationship between early menopause and the immune system. Finally, we will discuss the impact of menopausal hormone replacement therapy (HRT) on the immune system.

Anahtar Kelimeler

autoimmunity , hormone replacement therapy , immunity , menopause

Menopoz ve İmmunite Üzerine Bir Derleme

Öz

Menopozal geçiş kadın hayatında önemli bir yaşam olayıdır. Menopozal semptomlar temelde östrojen eksikliğinden kaynaklanır. Östrojen eksikliği uzun dönemde osteoporoz ve kardiyak olaylarda artış gibi problemlere de neden olmaktadır. Östrojen ekiskliğinin aynı zamanda bağışıklık üzerinde de etkileri olabilir. Bağışıklık sisteminin de menopoz üzerinde etkileri olabilir.
Bu derlemede menopozun bağışıklık sistemi, bağışıklık sisteminin de menopoz üzerindeki etkilerini özetleyeceğiz. Erken menopozun immün system üzerindeki etkilerini gözden geçireceğiz. Son olarak da hormon replasman tedavisinin (HRT) bağışıklık sistemi üzerindeki etkilerinden bahsedeceğiz.

Anahtar Kelimeler

otoimmunite , hormon replasman tedavisi , immunite , menopoz

Kaynakça

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