aku ijetas

Afyon Kocatepe Üniversitesi Uluslararası Mühendislik Teknolojileri ve Uygulamalı Bilimler Dergisi

2667-4165

Afyon Kocatepe Üniversitesi

10.53448/akuumubd.1111800

Engineering

Mühendislik

Asimetrik Michael Katılma Tepkimesi için Prolin bazlı β-Hidroksiamit Organokatalizörü

Prolines Based β-Hydroxyamide as Organocatalysts for Use in Asymmetric Michael Addition

https://orcid.org/0000-0002-9147-5938

Bozkurt

Selahattin

UŞAK ÜNİVERSİTESİ, SAĞLIK HİZMETLERİ MESLEK YÜKSEKOKULU

06 15 2022

5 1 13 17 04 30 2022 06 02 2022

2018

Afyon Kocatepe Üniversitesi Uluslararası Mühendislik Teknolojileri ve Uygulamalı Bilimler Dergisi

Michael katılması gibi C-C bağı oluşturma yeteneğine sahip reaksiyon tiplerinde, kiral organokatalizör uygulamaları son yılların önemli araştırma alanlarındandır. Organik reaksiyon tiplerinden önemli çalışmalarından biri olan Michael katılmasına en iyi örneklerden biri de organokatalizörler varlığında nitroolefinlerin ketonlar ile reaksiyonudur. Bu çalışmada; L-prolin bazlı amit türevi, ılımlı bir verim ile sentezi gerçekleştirilmiş ve yapısı çeşitli teknikler ile aydınlatılmıştır. Sentezi gerçekleştirilen bu bileşiğin; organokatalizör olarak, Michael katılma çalışmalarında enantiyomerik aşırılık (e.e.) üzerine etkisi incelenmiş ve en iyi enantiyomerik aşırılık değerinin karbontetra klorür (CCl4) içinde ve %65 olduğu tespit edilmiştir.

Applications of chiral organocatalysts in reaction types capable of forming C-C bonds, such as Michael addition, are one of the important research areas of recent years. One of the best examples of Michael addition, one of the important works of organic reaction types, is the reaction of nitroolefins with ketones in the presence of organocatalysts. In this study, L-proline-based amide derivative was synthesized with moderate yield and its structure was elucidated by various techniques. As an organocatalyst, its effect on enantiomeric excess (e.e.) was investigated in Michael addition studies and the best enantiomeric excess value was found to be 65% in carbontetra chloride (CCl4).

Michael addition Organocatalyst Enatiomeric excess L-Proline

Michael katılması Organokatalizör Enantiyomerik aşırılık L-Prolin

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