The Effect of Common and Possible Risk Factors’ Co-occurrence to the Development of Gestational Diabetes Mellitus

Yıl 2018, Cilt: 18 Sayı: 3, 382 - 390, 28.09.2018

Eren Gürkan , Emre Dirican Neşe Bülbül

https://doi.org/10.17098/amj.461421

Öz

Objectives: Advanced maternal age, obesity,
presence of family history of diabetes and macrosomic infant delivery are known
risk factors for gestational diabetes (GDM). The increase in pregnancy weight
and number of pregnancies are also possible risk factors. The purpose of this
study was to assess the association of known and possible risk factors with GDM
development.
Materials and Methods: A
case-control study was planned with a structured questionnaire on gestational
diabetes mellitus screening. For this purpose, pregnant patients who applied to
the Hatay State Hospital gynecology and obstetric outpatient clinic between
January and October 2017 were included in the study. 181 case records who were
applied a two-step oral glucose tolerance test (OGTT) were scanned. 102
participants were included in this study. In our study, the data were analyzed
statistically using 95% confidence, using the SPSS 22 (Statistical Package for
the Social Sciences) package program. The significance level of all the tests
used was determined to be 0,05. Pearson-ContinuityCorrection-FisherExactChi-Square
tests, binary logistic regression (enter method) analyzes were used in the
study.
Results: 74 of our 102 participants
(72.50%) were non-GDM and 28 (27.50%) were GDM. The average age is 29,04 ±
6.11. Univariate relations with GDM are investigated, age (p=0,001), prevalence
of GDM at previous pregnancies (p=0,002), presence of diabetes mellitus family
history (p=0,001), increase of body weight in pregnancy (p=0,011), presence of
glycosuria before pregnancy (p= 0,020), multiple pregnancies (p=0,012),
presence of macrosomic baby delivery (p=0,027). However, when the significance
of risk factors is evaluated together with logistic regression analysis,
advancing maternal age, multiple pregnancies and presence of diabetes mellitus
family history increases the risk of GDM. Body mass index (BMI) and the weight
of the first two trimester weight> 8 kg are not significant.
Conclusion: Presence of diabetes
mellitus family history, increased maternal age together with BMI, multiple
pregnancies increases GDM risk. These risk factors need to be considered in
prenatal screening.

Anahtar Kelimeler

Gestational diabetes mellitus, multiple pregnancies, maternal age, obesity

Bilinen ve Olası Risk Faktörlerinin Birlikteliğinin Gestasyonel Diyabetes Mellitus Gelişimine Etkisi

Öz

Objectives: Advanced maternal age,
obesity, presence of family history of diabetes and macrosomic infant delivery
are common risk factors for gestational diabetes (GDM). The increase in
pregnancy weight and number of pregnancies are also possible risk factors. The
purpose of this study was to assess the association of common and possible risk
factors with GDM development.
Materials and Methods: A
case-control study was planned with a structured questionnaire on GDM
screening. For this purpose, pregnant patients who applied to the Hatay State
Hospital gynecology and obstetric outpatient clinic between January and October
2017 were included in the study. 181 case records who were applied a two-step
oral glucose tolerance test (OGTT) were scanned. 102 participants were included
in this study. In our study, the data were analyzed statistically using 95%
confidence, using the SPSS 22 (Statistical Package for the Social Sciences)
package program. The significance level of all the tests used was determined to
be 0.05. Pearson-Continuity Correction-Fisher Exact Chi-Square tests, binary
logistic regression (enter method) analyzes were used in the study.

Results: 74 of our 102 participants
(72.50%) were non-GDM and 28 (27.50%) were GDM. The average age is 29.04 ±
6.11. Univariate relations with GDM are investigated, age (p=0.001), prevalence
of GDM at previous pregnancies (p=0.002), presence of diabetes mellitus family
history (p=0.001), increase of body weight in pregnancy (p=0.011), presence of
glycosuria before pregnancy (p= 0.020), multiple pregnancies (p=0.012),
presence of macrosomic baby delivery (p=0.027). However, when the significance
of risk factors is evaluated together with logistic regression analysis,
advancing maternal age, multiple pregnancies and presence of diabetes mellitus
family history increases the risk of GDM. Body mass index (BMI) and the weight
of the first two trimester weight> 8 kg are not significant.
Conclusion: Presence of diabetes
mellitus family history, increased maternal age together with BMI, multiple
pregnancies increases GDM risk. These risk factors need to be considered in
prenatal screening.

Anahtar Kelimeler

Gestasyonel diyabetes mellitus, artan gebelik sayısı, maternal yaş, obesite, ,

Kaynakça

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