anadolu klin Anatolian Clinic the Journal of Medical Sciences 2149-5254 2458-8849 Hayat Sağlık ve Sosyal Hizmetler Vakfı 10.21673/anadoluklin.180743 Health Care Administration Sağlık Kurumları Yönetimi Benign Prostat Hiperplazisi ve Antimuskarinik Tedavi Benign Prostatic Hyperplasia and Antimuscarinic Treatment Kaynar Mehmet Altıntaş Emre Göktaş Serdar 04 30 2016 21 2 163 168 03 03 2016 03 20 2016 Copyright © 1933, Anadolu Kliniği Tıp Bilimleri Dergisi 1933 Anadolu Kliniği Tıp Bilimleri Dergisi

Alt üriner sistem semptomları (AÜSS) terimi; üriner sistem semptomlarına sahip erkek hastaları değerlendirmede kullanılan prostatizm, semptomatik benign prostat hiperplazisi (BPH) ve klinik BPH terimlerinin yerini almaktadır. BPH, aşırı aktif mesane (AAM), nokturnal poliüri, üriner sistem enfeksiyonları, distal üreter taşları ve mesane tümörleri gibi birçok sağlık sorunu AÜSS’ye neden olabilir. Yaygın kullanılan bir terim olan AÜSS kapsamına giren semptomlar; depolama (acil idrar yapma hissi, sık idrara çıkma, gece idrar yapmak için uyanma ve urge inkontinans), işeme (işeme gücünde azalma, idrarı başlatmakta gecikme, kesik kesik idrar yapma) ve işeme sonrası (işeme sonrası damlama, yetersiz boşaltım hissi) ile ilgili semptomlar olarak üç alt grupta toplanmıştır. Günümüzde BPH için uygulanan en yaygın ve standart tıbbi tedavide α1-adrenerjik reseptör antagonistleri kullanılmaktadır. Bu tedavinin yetersiz kaldığı düşünülen durumlar için alternatif tedavi arayışları halen sürmektedir. Bu çalışmalar sonucunda, BPH’nin tedavisinde α1- blokerler ile birlikte kullanılan antimuskarinik ilaçlar, bir kombine tedavi olarak literatürdeki yerini almıştır. Bu derlemede; BPH’den muzdarip hastalarda antimuskarinik tedavilerinin etkinliği ve güvenilirliği değerlendirilmiştir.

The term lower tract urinary symptoms (LUTS) has been replacing the terms such as prostatism,symptomatic benign prostatic hyperplasia (BPH), and clinical BPH used in the evaluationof male patients with symptoms associated with the urinary system. Many health conditionsincluding BPH, overactive bladder (OAB), nocturnal polyuria, urinary tract infections, distal ureteralcalculi, and bladder tumors can cause LUTS. The symptoms covered by the commonlyused term LUTS are categorized into three subgroups; those associated with storage, those associatedwith urination, and those seen after urination. Today the standard and most commonmedical treatment for BPH is the use α1- adrenergic receptor blockers. However, the searchfor alternative treatment modalities continues, especially for situations in which α1-adrenergicreceptor blockers are considered as insufficient. With the relevant reports in the literature, thisled to the use of antimuscarinic drugs together with the α1-adrenergic receptor blockers as acombination therapy to treat BPH. This paper reviews the effectiveness and safety of the use ofantimuscarinic treatments in patients with BPH.

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