anadolu klin Anatolian Clinic the Journal of Medical Sciences 2149-5254 2458-8849 Hayat Sağlık ve Sosyal Hizmetler Vakfı 10.21673/anadoluklin.315155 Health Care Administration Sağlık Kurumları Yönetimi The Relatıonshıp between Neutrophil / Lymphocytes Ratio and Platelet / Lymphocytes Ratio wıth Prognosis in Operated Stage 1-2 of Non- Small Cell Lung Cancer Disease: One Central Experience Evre 1-2 Opere Küçük Hücreli Dışı Akciğer Kanseri Hastalarında Nötrofil/Lenfosit Oranı ve Platelet/Lenfosit Oranının Prognoz ile İlişkisi: Tek Merkez Deneyimi Ocak Duran Ayşe İleri İbrahim İnanç Mevlüde Bozkurt Oktay Özaslan Ersin Uçar Mahmut Özkan Metin 09 25 2017 22 3 149 156 05 21 2017 07 21 2017 Copyright © 1933, Anadolu Kliniği Tıp Bilimleri Dergisi 1933 Anadolu Kliniği Tıp Bilimleri Dergisi

Aim:The relationship between neutrophil / lymphocyte ratio (NLR) and platelet /lymphocyte ratio (PLR) and the prognosis of various cancers has beendemonstrated. However, the impact of NLR and PLR on the prognosis of non-smallcell lung cancer (NSCLC) remains controversial. The aim of this study was toinvestigate the prognostic value of NLR and PLR before surgery in stage 1-2NSCLC patients undergoing radical resection in our hospital.Materials and Methods:We included 59 patients with stage 1-2 NSCLC undergoing radical resection atour center between 2001 and 2014. The follow-up files of the patients werereviewed and necessary informations were obtained. Receiver operating curve(ROC) analysis was used for the optimal cut-off value of NLR and PLR (4.7 forNLR, 199 for PLR). The Kaplan-Meier univariate analysis wasused to examine the effect of NLR and PLR on overall survival (OS) anddisease-free survival (DFS). Results:There was no relationship between NLR and PLR classifications and clinicalparameters except for age. OS mean was 53 months, DFS mean was 43 months in thegroup with NLR < 4.7, OS mean was 44 months and DFS mean was 28 months inthe group with NLR> 4.7 (p = 0.031 for OS, p = 0.126 for DFS). OS mean was 55months, DFS mean was 39.5 months in the group with PLR < 199, OS mean was 42months, DFS mean was 30.6 months in the group with PLR > 199 (p=0,020 for OS,p=0,856 for DFS).Discussion and Conclusion:High pretreatment NLR and PLR values are independent predictors of poorprognosis in patients with opere lung cancer. Preoperative NLR and PLR valuescan be used as a prognostic parameter before radical resection in patients withstage 1-2 NSCLC.

Amaç:Nötrofil/lenfosit oranı (NLO) ve platelet/lenfosit oranı (PLO) ile çeşitlikanserlerin prognozu arasındaki ilişki gösterilmiştir. Ancak NLO ve PLO’ nun küçükhücreli dışı akciğer kanseri (KHDAK) prognozuna etkisi hala tartışmalıdır. Buçalışmamızın amacı, hastanemizde radikal rezeksiyon uygulanan Evre 1-2 KHDAKhastalarında operasyon öncesi NLO ve PLO’ nun prognostik değerini araştırmaktır.Gereç ve Yöntemler:Çalışmaya 2001-2014 yılları arasında merkezimizde takip edilen ve radikalrezeksiyon uygulanan 59 Evre 1-2 KHDAK hastası dahil edilmiştir. Hastalarıntakip dosyaları incelenmiş ve gerekli bilgiler alınmıştır. NLO ve PLO’ nunoptimal cut-off değeri için Receiver operating curve (ROC) analizikullanılmıştır (NLO için 4,7, PLO için 199). NLO ve PLO’ nun genel sağ kalım(GSK) ve hastalıksız sağ kalım (HSK) üzerine etkisini incelemek için TheKaplan-Meier univariate analysis kullanılmıştır. Bulgular:NLO ve PLO sınıflamaları ile klinik parametreler arasında yaş haricindeherhangi bir ilişki bulunmamıştır. NLO <4,7 olan gurupta GSK ortalaması 53ay, HSK ortalaması 43 ay, NLO > 4,7 olan grupta ise GSK ortalaması 44 ay,HSK ortalaması 28 ay, bulundu (GSK için p=0,031, HSK için p=0,126). PLO <199 olan gurupta GSK ortalaması 55 ay, HSK ortalaması 39,5 ay, PLO > 199olan gurupta ise GSK ortalaması 42 ay, HSK ortalaması 30,6 ay olarak bulundu(GSK için p=0,020, HSK için p=0,856).Tartışma ve Sonuç:Tedavi öncesi yüksek NLO ve PLO değerleri opere akciğer kanseri hastalarındakötü prognoz için bağımsız belirteçlerdir. Preoperatif NLO ve PLO değerleri,Evre 1-2 KHDAK hastalarında radikal rezeksiyon öncesi, prognostik bir parametre olarakkullanılabilir.

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