anadolu klin Anatolian Clinic the Journal of Medical Sciences 2149-5254 2458-8849 Hayat Sağlık ve Sosyal Hizmetler Vakfı 10.21673/anadoluklin.641856 Health Care Administration Sağlık Kurumları Yönetimi Clinical Features and Treatment Results of Metastatic Breast Cancer Patients: A Single Center Experience Metastatik Meme Kanserli Hastaların Klinik Özellikleri ve Tedavi Sonuçları: Tek Merkez Deneyimi https://orcid.org/0000-0001-6356-9059 Büyükşimşek Mahmut Çukurova Üniversitesi Tıp Fakültesi, Medikal Onkoloji Bilim Dalı, Adana https://orcid.org/0000-0003-4642-3693 Paydaş Semra Çukurova Üniversitesi Tıp Fakültesi, Medikal Onkoloji Bilim Dalı, Adana https://orcid.org/0000-0001-5437-2350 Başdoğan Servet Çukurova Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Adana https://orcid.org/0000-0003-0955-0781 Toğun Mustafa Çukurova Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Adana https://orcid.org/0000-0001-7214-8184 Yetişir Abdullah Evren Çukurova Üniversitesi Tıp Fakültesi, Medikal Onkoloji Bilim Dalı, Adana https://orcid.org/0000-0002-5986-5493 Mirili Cem Erzurum Atatürk Üniversitesi Tıp Fakültesi, Medikal Onkoloji Bilim Dalı, Erzurum https://orcid.org/0000-0003-4886-7060 Oğul Ali Adana Şehir Hastanesi, Medikal Onkoloji Bilim Dalı, Adana https://orcid.org/0000-0003-3653-4429 Tohumcuoğlu Mert Çukurova Üniversitesi Tıp Fakültesi, Medikal Onkoloji Bilim Dalı, Adana 06 13 2020 25 2 75 80 11 02 2019 02 25 2020 Copyright © 1933, Anadolu Kliniği Tıp Bilimleri Dergisi 1933 Anadolu Kliniği Tıp Bilimleri Dergisi

Aim: Breastcancer is the most common cancer that causes death in women. We wanted to investigatethe clinical features and treatment results of patients with metastatic breastcancer. Materials and Methods:Sixty-five patients with metastatic breast cancer followed in the OncologyDepartment of Cukurova University between 2011 and 2017 were included in thestudy. The clinical features and treatments of the patients were investigatedretrospectively.Results: Themajority of patients had only bone metastases. Re-biopsy was performed in 66,6%of 45 patients who subsequently underwent metastatic stage; and tumor biologyhad changed in 20% of these patients. The progression-freesurvival in the metastatic stage was 10 months and the overall survival was 34months.Discussion and Conclusion:Survivalof patients with metastatic breast cancer is consistent with the literature.When new agents and new therapies are also taken into consideration, re-biopsyat relapses is critical in considering the possibility of changes in diseasebiology.

Amaç:Meme kanserikadınlarda en sık görülen ve en sık ölüme neden olan kanserdir. Bizde merkezimizde takip ettiğimiz metastatik meme kanseri (MMK) olan hastaların kliniközelliklerini ve tedavi sonuçlarını araştırmak istedik.Gereçve Yöntemler: ÇukurovaÜniversitesi Onkoloji bilim dalında 2011-2017 yılları arasında takip edilen 65 MMKolan hasta çalışmaya dahil edildi. Hastaların klinik özellikleri ve aldıklarıtedaviler retrospektif olarak araştırıldı.Bulgular:Hastaların büyükçoğunluğunda sadece kemik metastazı vardı. Sonradan metastatik evreye geçen 45hastanın %66,6’ sına yeniden biyopsi yapıldı; bu hastaların %20’ sinde tümörbiyolojisi değişmişti. Metastatik evrede progresyonsuz sağkalım 10 ay, ortalamasağkalım 34 ay olarak hesaplandı.Tartışma ve Sonuç: MMKolan hastalarda literatürle uyumlu sağkalımlar elde edilmiştir. Yeni kullanımagiren ajanlar ve hedefleyici tedavilerdeki gelişmeler de göz önüne alındığındahastalık biyolojisindeki değişme ihtimali göz önünde bulundurularak relapslardayeniden biyopsi yapılması kritik önemdedir.

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