Anatomy of stem cells

Abstract

Human embryonic stem cells are important for the understanding of biologic mechanisms and their potential for treatment, and for toxicology studies. Mesenchymal stem cells can produce a good environment with chemical factors and signals to serve as anti-apoptotic, immune modulator and angiogenic, and can support regeneration in damaged tissues and induce faster and better wound healing. Stem cells have recently been shown in cancer tissue; these play a major role in the progression of cancer and the principal obstacle in treatment due to their resistance. Stem cells may participate in tissue homeostasis and regeneration which shows their capacity for cell therapies which makes them an amazing source for the clinical translation to treatment of diseases. Therefore, better understanding of the behavior of these cells and the mechanisms they use are important.

Keywords

• cancer
• embryonic
• hematopoietic
• mesenchymal
• pluripotent
• stem cell

References

1. Kurt FO, Vatansever HS. Potential clinical use of differentiated
2. cells from embryonic or mesenchymal stem cells in orthopeadic
3. problems. Curr Stem Cell Res Ther 2015;Mar 31. doi:10.2174/
4. X10666150401104259
5. Can A, Balci D. Isolation, culture, and characterization of human
6. umbilical cord stroma-derived mesenchymal stem cells. Methods
7. Mol Biol 2011;698:51–62.
8. Vatansever HS, Gumus B, Aydogdu O, Sivrikoz ON, TürközUluer

9. E, Kivanç M, Ateflçi YZ, Bugdayci H. The role of stem/progenitor
10. cells and Wnt/β-catenin signaling pathway in the patients
11. with prostate cancer. Minerva Urol Nefrol 2014;66:249–55.
12. Meirelles Lda S, Nardi NB. Methodology, biology and clinical
13. applications of mesenchymal stem cells. Front Biosci 2009;14:4281–
14. -
15. Ansieau S. EMT in breast cancer stem cell generation. Cancer Lett
16. ;338:63-8.
17. Sun Z, Wang S, Zhao RC. The roles of mesenchymal stem cells in
18. tumor inflammatory microenvironment. J Hematol Oncol 2014;7:
19. -
20. Brevini TA, Pennarossa G, Attanasio L, Vanelli A, Gasparrini B,
21. Gandolfi F. Culture conditions and signalling networks promoting
22. the establishment of cell lines from parthenogenetic and biparental
23. pig embryos. Stem Cell Rev 2010;6:484–95.
24. King CC. Culture and preparation of human embryonic stem cells
25. for proteomics-based applications. Methods Mol Biol 2010;584:
26. –77.
27. Findikli N, Candan NZ, Kahraman S. Human embryonic stem cell
28. culture: current limitations and novel strategies. Reprod Biomed
29. Online 2006;13:581–90.
30. Telias M, Ben-Yosef D. Modeling neurodevelopmental disorders
31. using human pluripotent stem cells. Stem Cell Rev 2014;10:494–
32. -
33. Ha HY, Jang SH, Jung JW. The use of pluripotent stem cell for
34. personalized cell therapies against neurological disorders. J
35. Biomed Biotechnol 2011;2011.520816.
36. Can A, Karahuseyinoglu S. Concise review: human umbilical cord
37. stroma with regard to the source of fetus-derived stem cells. Stem
38. Cells 2007;25:2886–95.
39. Saito MT, Silvério KG, Casati MZ, Sallum EA, Nociti FH Jr.
40. Tooth-derived stem cells: update and perspectives. World J Stem
41. Cells 2015;7:399–407.
42. Roll L, Faissner A. Influence of the extracellular matrix on endogenous
43. and transplanted stem cells after brain damage. Front Cell
44. Neurosci 2014;8:219.
45. Nadal-Ginard B, Ellison GM, Torella D. The cardiac stem cell
46. compartment is indispensable for myocardial cell homeostasis,
47. repair and regeneration in the adult. Stem Cell Res 2014;13:615–
48. -
49. Sándor GK, Tuovinen VJ, Wolff J, Patrikoski M, Jokinen J,
50. Nieminen E, Mannerström B, Lappalainen OP, Seppänen R,Miettinen S. Adipose stem cell tissue-engineered construct used to
51. treat large anterior mandibular defect: a case report and review of
52. the clinical application of good manufacturing practice-level adipose
53. stem cells for bone regeneration. J Oral Maxillofac Surg 2013;
54. :938–50.
55. Vestentoft PS. Development and molecular composition of the
56. hepatic progenitor cell niche. Dan Med J 2013;60:B4640.
57. Murray IR, West CC, Hardy WR, James AW, Park TS, Nguyen
58. A, Tawonsawatruk T, Lazzari L, Soo C, Péault B. Natural history
59. of mesenchymal stem cells, from vessel walls to culture vessels.
60. Cell Mol Life Sci 2014;71:1353–74.
61. Wang X, Zachman AL, Haglund NA, Maltais S, Sung HJ.
62. Combined usage of stem cells in end-stage heart failure therapies.
63. J Cell Biochem 2014;115:1217–24.
64. Gülen H, Tüzün F, Ayhan Y, Erbay A, Oztürk E, Inan S, Vergin
65. C. The evaluation of blood donor deferral causes. Pediatr Hematol
66. Oncol 2006;23:91–4.
67. Van Camp JK, Beckers S, Zegers D, Van Hul W. Wnt signaling
68. and the control of human stem cell fate. Stem Cell Rev
69. ;10:207–29.
70. Sawitzki B, Brunstein C, Meisel C, Schumann J, Vogt K, Appelt C,
71. Curtsinger JM, Verneris MR, Miller JS, Wagner JE, Blazar BR.
72. Prevention of graft-versus-host disease by adoptive T regulatory
73. therapy is associated with active repression of peripheral blood
74. Toll-like receptor 5 mRNA expression. Biol Blood Marrow
75. Transplant 2014;20:173–82.
76. Introna M, Rambaldi A. Mesenchymal stromal cells for prevention
77. and treatment of graft-versus-host disease: successes and hurdles.
78. Curr Opin Organ Transplant 2015;20:72–8.