Effects of alcohol and tramadol co-treatment on cognitive functions and neuro-inflammatory responses in the medial prefrontal cortex of juvenile male rats

Yıl 2019, Cilt: 13 Sayı: 1, 1 - 12, 29.04.2019

Damilare Adedayo Adekomi Adebiyi Aderinola Adegoke Olayinka Olaolu Olaniyan Adepeju Ester Ogunrinde Olayemi Kafilat Ijomone

Öz

Objectives: Misuse and abuse of drugs are on the increase amongst juvenile individuals across the world. This study was
carried out to evaluate the cognitive and subcellular neuropathologic events in the medial prefrontal cortex (mPFC) of juvenile male rats following exposure to alcohol and tramadol hydrochloride.

Methods: The rats were assigned into four groups; vehicle group, alcohol group, tramadol group, and the alcohol+tramadol
combined group. Twenty-four hours after the administration of the last dose, 5 rats from each group were sacrificed. The mPFCs
were excised and were stained with either cresyl violet or glia fibrillary acidic protein immunoreactivity. The remaining rats in each
of the groups were subjected to cognitive behavioural tests.

Results: The administration of alcohol, tramadol and the co-administration of alcohol+tramadol triggers astrogliosis, glial scars
and inflammatory responses relative to the vehicle-treated with well-preserved profile. The distribution of Nissl substances suggested that the neurons are either undergoing neurodegeneration or neuronal metabolism impairment. The behavioural tests
showed that the administration of the respective substances impaired cognition in the treated rats compared to the vehicle-treated rats.

Conclusion: This study concluded that alcohol, tramadol, and alcohol+tramadol misuse can impair the functional integrity
of the medial prefrontal cortex. 

Anahtar Kelimeler

brain; cognition; drug misuse; learning; memory; neural degeneration

Kaynakça

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