Yıl 2019, Cilt 13 , Sayı 1, Sayfalar 1 - 12 2019-04-29

Effects of alcohol and tramadol co-treatment on cognitive functions and neuro-inflammatory responses in the medial prefrontal cortex of juvenile male rats

Damilare Adedayo Adekomi [1] , Adebiyi Aderinola Adegoke [2] , Olayinka Olaolu Olaniyan [3] , Adepeju Ester Ogunrinde [4] , Olayemi Kafilat Ijomone [5]


Objectives: Misuse and abuse of drugs are on the increase amongst juvenile individuals across the world. This study was carried out to evaluate the cognitive and subcellular neuropathologic events in the medial prefrontal cortex (mPFC) of juvenile male rats following exposure to alcohol and tramadol hydrochloride.

Methods: The rats were assigned into four groups; vehicle group, alcohol group, tramadol group, and the alcohol+tramadol combined group. Twenty-four hours after the administration of the last dose, 5 rats from each group were sacrificed. The mPFCs were excised and were stained with either cresyl violet or glia fibrillary acidic protein immunoreactivity. The remaining rats in each of the groups were subjected to cognitive behavioural tests.

Results: The administration of alcohol, tramadol and the co-administration of alcohol+tramadol triggers astrogliosis, glial scars and inflammatory responses relative to the vehicle-treated with well-preserved profile. The distribution of Nissl substances suggested that the neurons are either undergoing neurodegeneration or neuronal metabolism impairment. The behavioural tests showed that the administration of the respective substances impaired cognition in the treated rats compared to the vehicle-treated rats.

Conclusion: This study concluded that alcohol, tramadol, and alcohol+tramadol misuse can impair the functional integrity of the medial prefrontal cortex. 

brain; cognition; drug misuse; learning; memory; neural degeneration
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Birincil Dil en
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Original Articles
Yazarlar

Yazar: Damilare Adedayo Adekomi (Sorumlu Yazar)

Yazar: Adebiyi Aderinola Adegoke

Yazar: Olayinka Olaolu Olaniyan

Yazar: Adepeju Ester Ogunrinde

Yazar: Olayemi Kafilat Ijomone

Tarihler

Yayımlanma Tarihi : 29 Nisan 2019

Bibtex @araştırma makalesi { anatomy615122, journal = {Anatomy}, issn = {1307-8798}, eissn = {1308-8459}, address = {}, publisher = {Türk Anatomi ve Klinik Anatomi Derneği}, year = {2019}, volume = {13}, pages = {1 - 12}, doi = {}, title = {Effects of alcohol and tramadol co-treatment on cognitive functions and neuro-inflammatory responses in the medial prefrontal cortex of juvenile male rats}, key = {cite}, author = {Adekomi, Damilare Adedayo and Adegoke, Adebiyi Aderinola and Olaniyan, Olayinka Olaolu and Ogunrinde, Adepeju Ester and Ijomone, Olayemi Kafilat} }
APA Adekomi, D , Adegoke, A , Olaniyan, O , Ogunrinde, A , Ijomone, O . (2019). Effects of alcohol and tramadol co-treatment on cognitive functions and neuro-inflammatory responses in the medial prefrontal cortex of juvenile male rats. Anatomy , 13 (1) , 1-12 . Retrieved from https://dergipark.org.tr/tr/pub/anatomy/issue/48567/615122
MLA Adekomi, D , Adegoke, A , Olaniyan, O , Ogunrinde, A , Ijomone, O . "Effects of alcohol and tramadol co-treatment on cognitive functions and neuro-inflammatory responses in the medial prefrontal cortex of juvenile male rats". Anatomy 13 (2019 ): 1-12 <https://dergipark.org.tr/tr/pub/anatomy/issue/48567/615122>
Chicago Adekomi, D , Adegoke, A , Olaniyan, O , Ogunrinde, A , Ijomone, O . "Effects of alcohol and tramadol co-treatment on cognitive functions and neuro-inflammatory responses in the medial prefrontal cortex of juvenile male rats". Anatomy 13 (2019 ): 1-12
RIS TY - JOUR T1 - Effects of alcohol and tramadol co-treatment on cognitive functions and neuro-inflammatory responses in the medial prefrontal cortex of juvenile male rats AU - Damilare Adedayo Adekomi , Adebiyi Aderinola Adegoke , Olayinka Olaolu Olaniyan , Adepeju Ester Ogunrinde , Olayemi Kafilat Ijomone Y1 - 2019 PY - 2019 N1 - DO - T2 - Anatomy JF - Journal JO - JOR SP - 1 EP - 12 VL - 13 IS - 1 SN - 1307-8798-1308-8459 M3 - UR - Y2 - 2019 ER -
EndNote %0 Anatomy Effects of alcohol and tramadol co-treatment on cognitive functions and neuro-inflammatory responses in the medial prefrontal cortex of juvenile male rats %A Damilare Adedayo Adekomi , Adebiyi Aderinola Adegoke , Olayinka Olaolu Olaniyan , Adepeju Ester Ogunrinde , Olayemi Kafilat Ijomone %T Effects of alcohol and tramadol co-treatment on cognitive functions and neuro-inflammatory responses in the medial prefrontal cortex of juvenile male rats %D 2019 %J Anatomy %P 1307-8798-1308-8459 %V 13 %N 1 %R %U
ISNAD Adekomi, Damilare Adedayo , Adegoke, Adebiyi Aderinola , Olaniyan, Olayinka Olaolu , Ogunrinde, Adepeju Ester , Ijomone, Olayemi Kafilat . "Effects of alcohol and tramadol co-treatment on cognitive functions and neuro-inflammatory responses in the medial prefrontal cortex of juvenile male rats". Anatomy 13 / 1 (Nisan 2019): 1-12 .
AMA Adekomi D , Adegoke A , Olaniyan O , Ogunrinde A , Ijomone O . Effects of alcohol and tramadol co-treatment on cognitive functions and neuro-inflammatory responses in the medial prefrontal cortex of juvenile male rats. Anatomy. 2019; 13(1): 1-12.
Vancouver Adekomi D , Adegoke A , Olaniyan O , Ogunrinde A , Ijomone O . Effects of alcohol and tramadol co-treatment on cognitive functions and neuro-inflammatory responses in the medial prefrontal cortex of juvenile male rats. Anatomy. 2019; 13(1): 12-1.